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    Use of cyclodextrins to modulate gene expression with reduced immunostimulatory response
    8.
    发明授权
    Use of cyclodextrins to modulate gene expression with reduced immunostimulatory response 失效
    使用环糊精调节基因表达减少的免疫刺激反应

    公开(公告)号：US06667293B1

    公开(公告)日：2003-12-23

    申请号：US08527126

    申请日：1995-09-12

    申请人： Qiuyan Zhao ,  Jamal Temsamani ,  Sudhir Agrawal

    发明人： Qiuyan Zhao ,  Jamal Temsamani ,  Sudhir Agrawal

    IPC分类号： A01N4304

    CPC分类号： B82Y5/00 ,  A61K47/6951

    摘要： The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen-mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by administering the phosphorothioate oligonucleotide in a therapeutic formulation which includes at least one cyclodextrin to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.

    摘要翻译： 本发明提供降低用于治疗病原体介导的疾病状态和其他医学病症的某些硫代磷酸酯寡核苷酸的免疫刺激作用的方法。 根据本发明的方法，通过将硫代磷酸酯寡核苷酸给予包含至少一种环糊精的治疗制剂给予所治疗的疾病或病症的哺乳动物，降低了硫代磷酸酯寡核苷酸的免疫刺激作用。 还在本发明的方法中监测哺乳动物的免疫应答。