发明授权
US5968909A Method of modulating gene expression with reduced immunostimulatory
response
失效
用免疫刺激反应降低调节基因表达的方法
- 专利标题： Method of modulating gene expression with reduced immunostimulatory response
- 专利标题（中）： 用免疫刺激反应降低调节基因表达的方法
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申请号： US511536申请日： 1995-08-04
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公开(公告)号： US5968909A公开(公告)日： 1999-10-19
- 发明人: Sudhir Agrawal , Jamal Temsamani , Qiuyan Zhao
- 申请人： Sudhir Agrawal , Jamal Temsamani , Qiuyan Zhao
- 申请人地址： MA Milford
- 专利权人： Hybridon, Inc.
- 当前专利权人： Hybridon, Inc.
- 当前专利权人地址： MA Milford
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/00 ; A61K31/70 ; A61K31/7088 ; A61K31/7125 ; A61K48/00 ; A61P31/00 ; A61P35/00 ; C07H21/00 ; C07H21/04
摘要：
The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen-mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by modifying at least one chemical structure within the phosphorothioate oligonucleotide to produce an immunostimulatory response-reducing phosphorothioate oligonucleotide, which is then administered to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.
公开/授权文献
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