公开(公告)号：US09814406B2

公开(公告)日：2017-11-14

申请号：US14478707

申请日：2014-09-05

申请人： PACESETTER, INC.

发明人： Hoda Razavi ,  Fujian Qu ,  Kyungmoo Ryu ,  Yelena Nabutovsky

IPC分类号： A61B5/04 ,  A61B5/0468 ,  A61B5/11 ,  A61B5/00 ,  A61B34/20

CPC分类号： A61B5/0468 ,  A61B5/1102 ,  A61B5/721 ,  A61B2034/2051

摘要： Methods and system are provided that identify motion data associated with consistent electrical and mechanical behavior for a region of interest of the heart. The methods and systems acquire electrical cardiac signals indicative of physiologic behavior of at least a portion of the heart over a plurality of cardiac cycles. The methods and systems acquires motion data indicative of mechanical behavior of a motion sensor over the plurality of cardiac cycles to form a motion data collection, the motion data indicative of mechanical behavior of the region of interest when the motion sensor is in contact with the region of interest. The designating ectopic beats within the cardiac cycles may be based on the electrical cardiac signals, the ectopic beats producing electrically inconsistent (EI) data within the motion data collection. The methods and systems identify mechanically inconsistent (MI) data within the motion data collection based on irregular changes in the motion data. The methods and systems remove at least a portion of the EI and MI data from the motion data collection based on the designating and identifying operations to form an electrically/mechanically consistent (EMC) motion data collection.

公开(公告)号：US09561376B2

公开(公告)日：2017-02-07

申请号：US14609196

申请日：2015-01-29

申请人： Pacesetter, Inc.

发明人： Fujian Qu ,  Hoda Razavi ,  Yelena Nabutovsky

IPC分类号： A61N1/36 ,  A61N1/368 ,  A61N1/365 ,  A61N1/362

CPC分类号： A61N1/3686 ,  A61N1/3627 ,  A61N1/36578

摘要： The present disclosure provides systems and methods for estimating a change in an intracardiac distance between systole and diastole. A system includes a pacing electrode configured to generate a pacing pulse, a sensing electrode configured to measure an electrical artifact corresponding to the pacing pulse, and a computing device communicatively coupled to the pacing electrode and the sensing electrode, the computing device configured to determine a first amplitude of a first electrical artifact measured at the sensing electrode during systole, determine a second amplitude of a second electrical artifact measured at the sensing electrode during diastole, and calculate a mechanical index based on the first amplitude and the second amplitude, wherein the mechanical index is representative of the change in the intracardiac distance.

摘要翻译： 本公开提供了用于估计心脏和心脏舒张之间心脏距离变化的系统和方法。 一种系统包括配置成产生起搏脉冲的起搏电极，配置成测量与起搏脉冲对应的电假象的感测电极，以及通信地耦合到起搏电极和检测电极的计算装置，该计算装置被配置成确定 在收缩期间在感测电极处测量的第一电气伪影的第一幅度确定舒张期期间在感测电极处测量的第二电假象的第二幅度，并且基于第一幅度和第二幅度计算机械指数，其中机械 指数代表心内距离的变化。

公开(公告)号：US20160354158A1

公开(公告)日：2016-12-08

申请号：US14732371

申请日：2015-06-05

申请人： PACESETTER, INC.

发明人： Hoda Razavi ,  Kyungmoo Ryu

IPC分类号： A61B34/20 ,  A61B5/0402 ,  A61B5/06 ,  A61B90/00

CPC分类号： A61B34/20 ,  A61B5/0402 ,  A61B5/066 ,  A61B90/37 ,  A61B2034/2048 ,  A61B2090/376 ,  A61B2090/3762 ,  A61B2090/3764 ,  G06T2207/30101

摘要： Methods and systems are provided for generating a virtual venous image. The methods and systems utilize an intravascular mapping tool configured to be inserted into a venous structure of an object of interest. The methods and systems further acquire a plurality of position data points at predetermined intervals corresponding to a position of the intravascular mapping tool within the venous structure, and adjust each position data point based on at least one of a cardiac motion or a respiratory motion of the object of interest. The methods and systems also display a travelled path of the intravascular mapping tool on the display based on the adjusted position data points.

摘要翻译： 提供了用于产生虚拟静脉图像的方法和系统。 所述方法和系统利用构造成插入感兴趣对象的静脉结构的血管内测绘工具。 所述方法和系统进一步以对应于静脉结构内的血管内测绘工具的位置的预定间隔获取多个位置数据点，并且基于以下步骤中的至少一个来调整每个位置数据点：心脏运动或呼吸运动 感兴趣的对象 所述方法和系统还基于调整后的位置数据点在显示器上显示血管内测绘工具的行进路径。

公开(公告)号：US09302099B2

公开(公告)日：2016-04-05

申请号：US14703760

申请日：2015-05-04

申请人： Pacesetter, Inc.

发明人： Hoda Razavi ,  Yelena Nabutovsky ,  Rohan A. More ,  Kyungmoo Ryu ,  Luke C. McSpadden

IPC分类号： A61N1/00 ,  A61N1/05

CPC分类号： A61N1/057 ,  A61N1/056 ,  A61N2001/0578 ,  A61N2001/083

摘要： A method and system are provided that provide feedback regarding lead stability for a candidate target vessel, and provide guidance on a type of lead to be used. The method and system utilize a surgical navigation system and information regarding patient anatomy to predict lead stability within the patient anatomy. The method and system provide patient-specific force measurements for one or more vessels of a patient.

摘要翻译： 提供了一种方法和系统，其提供关于候选目标船的铅稳定性的反馈，并且提供关于要使用的铅的类型的指导。 该方法和系统利用外科导航系统和关于患者解剖学的信息来预测患者解剖结构内的铅稳定性。 该方法和系统为患者的一个或多个血管提供针对患者的力测量。

公开(公告)号：US20150313480A1

公开(公告)日：2015-11-05

申请号：US14270186

申请日：2014-05-05

申请人： Pacesetter Inc.

发明人： Hoda Razavi ,  Kyungmoo Ryu ,  Yelena Nabutovsky

IPC分类号： A61B5/02 ,  A61B5/11 ,  G06F19/00

CPC分类号： A61B5/11 ,  A61B5/02028 ,  A61B5/042 ,  A61B5/062 ,  A61B5/1102 ,  A61B5/1107 ,  A61B6/12 ,  A61B6/4441 ,  A61B6/487 ,  A61B6/503 ,  A61B6/504 ,  A61B6/5247 ,  A61B2576/023 ,  G06F19/00 ,  G06F19/321 ,  G06F19/34

摘要： A method and system is provided for calculating a strain from characterization motion data. The method and system utilize an intravascular mapping tool configured to be inserted into at least one of the endocardial or epicardial space. The mapping tool is maneuvered to select locations proximate to surfaces of the heart, while collecting map points at the select locations to form a point cloud data set during at least one cardiac cycle. The method and system further include automatically assigning segment identifiers (IDs) to the map points based on a position of the map point within the point cloud data set. The method and system further select a first and second reference from a group of map points. Further, the method and system calculate a linear strain based on an instantaneous distance and a reference distance between the first and second references.

摘要翻译： 提供了一种从表征运动数据计算应变的方法和系统。 该方法和系统利用构造成插入到心内膜或心外膜空间中的至少一个中的血管内测绘工具。 映射工具被操纵以选择靠近心脏表面的位置，同时在选择位置处收集地图点以在至少一个心动周期期间形成点云数据集。 该方法和系统还包括基于点云数据集内的地图点的位置，自动地将分段标识符（ID）分配给地图点。 所述方法和系统还从一组地图点中选择第一和第二参考。 此外，该方法和系统基于第一和第二参考之间的瞬时距离和参考距离来计算线性应变。

公开(公告)号：US09364170B2

公开(公告)日：2016-06-14

申请号：US14270181

申请日：2014-05-05

申请人： Pacesetter Inc.

发明人： Yelena Nabutovsky ,  Hoda Razavi

IPC分类号： A61B5/04 ,  A61B5/11 ,  A61B5/042 ,  A61B5/06 ,  A61B5/00

CPC分类号： A61B5/1126 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/061 ,  A61B5/062 ,  A61B5/1102 ,  A61B5/1107 ,  A61B5/6869 ,  A61B5/7278 ,  A61B5/7289

摘要： A method and system are provided for characterizing motion data. The method and system obtain point specific (PS) motion data for a plurality of map points. The PS motion data indicates an amount of motion that occurred at the corresponding map point on a wall of the heart during at least one cardiac cycle. The method and system, calculate mechanical activation times (MAT) for the map points, identifying a group of neighbor map points for a current map point, and modifying the MAT corresponding to the current map point based on the MATs corresponding to at least a portion of the group of neighboring map points. Further, the method and system repeat the identifying and modifying operations for at least a subset of the map points.

摘要翻译： 提供了用于表征运动数据的方法和系统。 方法和系统获得多个地图点的点特定（PS）运动数据。 PS运动数据指示在至少一个心动周期期间发生在心脏壁上的对应地图点处的运动量。 该方法和系统计算地图点的机械激活时间（MAT），识别当前地图点的一组邻近地图点，并且基于与至少一部分相对应的MAT修改与当前地图点相对应的MAT 的相邻地图点组。 此外，该方法和系统重复对于地图点的至少一个子集的识别和修改操作。

公开(公告)号：US09345550B2

公开(公告)日：2016-05-24

申请号：US14069209

申请日：2013-10-31

申请人： Pacesetter, Inc.

发明人： Sergio Richter ,  Philipp Sommer ,  Edith Arnold ,  Hoda Razavi ,  Yelena Nabutovsky ,  Fujian Qu

IPC分类号： A61B19/00 ,  A61N1/362 ,  A61N1/05 ,  A61N1/37

CPC分类号： A61B34/10 ,  A61N1/056 ,  A61N1/3627 ,  A61N1/37

摘要： A method and system for characterizing an accessibility of potential left ventricular stimulus sites in connection with surgical planning for transvenous implant of a cardiac medical lead in or near a heart of a patient are provided. The method and system include obtaining image data representative of a coronary venous system for the heart of the patient to receive the lead. The method and system generate a venous map, based on the image data, representative of venous pathways for the heart of the patient. The method and system analyze the venous map to identify pathway features of interest (PFOI) within at least one select region of the venous pathways. The method and system assign scores to the PFOI based on at least one of predetermined feature-complexity relations or physician-entered complexity updates. The method and system display treatment planning information to a user based on the scores.

摘要翻译： 提供了一种用于表征潜在的左心室刺激部位与外科手术规划的可及性的方法和系统，用于在患者的心脏中或其附近的心脏医学铅的静脉植入。 该方法和系统包括获得代表患者心脏的冠状静脉系统的图像数据以接收铅。 该方法和系统基于图像数据产生静脉图，代表患者心脏的静脉通路。 该方法和系统分析静脉图以在静脉通路的至少一个选择区域中鉴定感兴趣的途径特征（PFOI）。 所述方法和系统基于预定特征 - 复杂度关系或医师进入的复杂度更新中的至少一个向PFOI分配分数。 该方法和系统根据分数向用户显示治疗计划信息。

公开(公告)号：US20150314121A1

公开(公告)日：2015-11-05

申请号：US14703760

申请日：2015-05-04

申请人： Pacesetter, Inc.

发明人： Hoda Razavi ,  Yelena Nabutovsky ,  Rohan A. More ,  Kyungmoo Ryu ,  Luke C. McSpadden

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N1/056 ,  A61N2001/0578 ,  A61N2001/083

摘要： A method and system are provided that provide feedback regarding lead stability for a candidate target vessel, and provide guidance on a type of lead to be used. The method and system utilize a surgical navigation system and information regarding patient anatomy to predict lead stability within the patient anatomy. The method and system provide patient-specific force measurements for one or more vessels of a patient.

摘要翻译： 提供了一种方法和系统，其提供关于候选目标船的铅稳定性的反馈，并且提供关于要使用的铅的类型的指导。 该方法和系统利用外科导航系统和关于患者解剖学的信息来预测患者解剖结构内的铅稳定性。 该方法和系统为患者的一个或多个血管提供针对患者的力测量。

公开(公告)号：US20150313495A1

公开(公告)日：2015-11-05

申请号：US14703757

申请日：2015-05-04

申请人： Pacesetter, Inc.

发明人： Yelena Nabutovsky ,  Hoda Razavi

IPC分类号： A61B5/0452 ,  A61N1/365 ,  A61B5/042 ,  A61B5/02

CPC分类号： A61N1/3684 ,  A61B5/02 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/061 ,  A61B5/4836 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36592 ,  A61N1/3682

摘要： Embodiments of the present disclosure provide a method of determining an inter-chamber delay within a heart of an individual that may include determining a position of a first sensor in a first chamber of the heart, determining a position of a second sensor in a second chamber of the heart, automatically computing a distance between the first and second sensors, and automatically determining the inter-chamber delay based on the automatically computing operation.

摘要翻译： 本公开的实施例提供一种确定个体心脏内的室间延迟的方法，其可以包括确定心脏的第一腔室中的第一传感器的位置，确定第二传感器在第二腔室中的位置 自动计算第一和第二传感器之间的距离，并且基于自动计算操作自动确定室间延迟。

公开(公告)号：US20150141858A1

公开(公告)日：2015-05-21

申请号：US14328513

申请日：2014-07-10

申请人： Pacesetter, inc.

发明人： Hoda Razavi ,  Yelena Nabutovsky ,  Kyungmoo Ryu

IPC分类号： A61B5/02 ,  A61B5/11 ,  A61B5/00 ,  A61B5/0452

CPC分类号： A61B5/1107 ,  A61B5/04014 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/062 ,  A61B5/066 ,  A61B5/1114 ,  A61B5/1122 ,  A61B5/1128 ,  A61B5/113 ,  A61B5/6852 ,  A61B5/6869 ,  A61B5/721 ,  A61B5/7289 ,  A61B5/7435 ,  A61B6/4441 ,  A61B6/469 ,  A61B6/487 ,  A61B6/501 ,  A61B6/527 ,  A61B6/5288 ,  A61B2034/107 ,  A61B2090/3983

摘要： A method and system are provided to measure cardiac motion data using a cardiovascular navigation system. The method and system position a patient reference sensor (PRS) on a patient, wherein the PRS determines a position of the patient relative to a reference point. The method and system determine a reference orientation matrix based on an orientation of the PRS relative to a reference point and determining a normalization time based on an electrical signal. The method and system obtain point specific (PS) motion data for a plurality of map points. The PS motion data indicates a three dimensional trajectory that occurs at the corresponding map point on a wall of a heart of the patient during at least one cardiac cycle. Further the method and system compensate the PS motion data based on the PRS.

摘要翻译： 提供了一种使用心血管导航系统来测量心脏运动数据的方法和系统。 方法和系统将患者参考传感器（PRS）定位在患者身上，其中PRS确定患者相对于参考点的位置。 该方法和系统基于PRS相对于参考点的取向来确定参考取向矩阵，并且基于电信号确定归一化时间。 方法和系统获得多个地图点的点特定（PS）运动数据。 PS运动数据表示在至少一个心动周期期间发生在患者心脏壁上的对应图形点处的三维轨迹。 此外，该方法和系统基于PRS补偿PS运动数据。