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    Microorganisms for the production of insect pheromones and related compounds
    3.
    发明授权
    Microorganisms for the production of insect pheromones and related compounds 有权

    公开(公告)号：US11109596B2

    公开(公告)日：2021-09-07

    申请号：US16420566

    申请日：2019-05-23

    Applicant: Provivi, Inc.

    Inventor： Effendi Leonard ,  Peter Meinhold ,  Keith Wampler ,  Pedro Coelho ,  Micah Sheppard ,  Thomas Heel

    IPC: A01N63/50 ,  C12P7/64 ,  A01N31/02 ,  C12N9/02 ,  C12P7/04

    Abstract: The present application relates to recombinant microorganisms useful in the biosynthesis of unsaturated C6-C24 fatty alcohols, aldehydes, and acetates which may be useful as insect pheromones, fragrances, flavors, and polymer intermediates. The C6-C24 fatty alcohols, aldehydes, and acetates described herein may be used as substrates for metathesis reactions to expand the repertoire of target compounds and pheromones. The application further relates to recombinant microorganisms co-expressing a pheromone pathway and a pathway for the production of a toxic protein, peptide, oligonucleotide, or small molecule suitable for use in an attract-and-kill pest control approach. Also provided are methods of producing unsaturated C6-C24 fatty alcohols, aldehydes, and acetates using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or optionally one or more of the product alcohols, aldehydes, or acetates.

    PRODUCTION OF FATTY OLEFIN DERIVATIVES VIA OLEFIN METATHESIS
    6.
    发明申请
    PRODUCTION OF FATTY OLEFIN DERIVATIVES VIA OLEFIN METATHESIS 有权

    公开(公告)号：US20220032280A1

    公开(公告)日：2022-02-03

    申请号：US17390136

    申请日：2021-07-30

    Applicant: Provivi, Inc.

    Inventor： Keith M. Wampler ,  Peter Meinhold ,  Pedro Coelho ,  Vu Bui ,  Hasan Mehdi

    IPC: B01J31/22 ,  C07C29/147 ,  C07C67/08 ,  C07C67/343 ,  C07C45/41 ,  C07C6/04 ,  C07C67/293

    Abstract: In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.

    Production of fatty olefin derivatives via olefin metathesis
    7.
    发明授权
    Production of fatty olefin derivatives via olefin metathesis 有权

    公开(公告)号：US10596562B2

    公开(公告)日：2020-03-24

    申请号：US15721018

    申请日：2017-09-29

    Applicant: Provivi, Inc.

    Inventor： Keith M. Wampler ,  Peter Meinhold ,  Pedro Coelho ,  Vu Bui ,  Levente Ondi ,  Hasan Mehdi

    IPC: B01J31/22 ,  C07C67/293 ,  C07C67/343 ,  C07C67/08 ,  C07C45/41 ,  C07C29/147 ,  C07C6/04

    Abstract: In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.

    Microorganisms for the production of insect pheromones and related compounds
    8.
    发明授权
    Microorganisms for the production of insect pheromones and related compounds 有权

    公开(公告)号：US10308962B1

    公开(公告)日：2019-06-04

    申请号：US15983706

    申请日：2018-05-18

    Applicant: Provivi, Inc.

    Inventor： Effendi Leonard ,  Peter Meinhold ,  Keith Wampler ,  Pedro Coelho ,  Micah Sheppard ,  Thomas Heel

    IPC: C12P7/04 ,  C12N9/02 ,  A01N31/02

    Abstract: The present application relates to recombinant microorganisms useful in the biosynthesis of unsaturated C6-C24 fatty alcohols, aldehydes, and acetates which may be useful as insect pheromones, fragrances, flavors, and polymer intermediates. The C6-C24 fatty alcohols, aldehydes, and acetates described herein may be used as substrates for metathesis reactions to expand the repertoire of target compounds and pheromones. The application further relates to recombinant microorganisms co-expressing a pheromone pathway and a pathway for the production of a toxic protein, peptide, oligonucleotide, or small molecule suitable for use in an attract-and-kill pest control approach. Also provided are methods of producing unsaturated C6-C24 fatty alcohols, aldehydes, and acetates using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or optionally one or more of the product alcohols, aldehydes, or acetates.

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