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    PH sensitive biodegradable polymeric particles for drug delivery
    2.
    发明授权
    PH sensitive biodegradable polymeric particles for drug delivery 有权
    PH敏感的生物可降解聚合物颗粒用于药物递送

    公开(公告)号：US09532956B2

    公开(公告)日：2017-01-03

    申请号：US12762348

    申请日：2010-04-18

    申请人： Aleksandar Filip Radovic-Moreno ,  Weiwei Gao ,  Archana Swami ,  Gershon Golomb ,  Robert S. Langer ,  Omid C. Farokhzad

    发明人： Aleksandar Filip Radovic-Moreno ,  Weiwei Gao ,  Archana Swami ,  Gershon Golomb ,  Robert S. Langer ,  Omid C. Farokhzad

    IPC分类号： A61K47/30 ,  G01N21/76 ,  A61K9/51 ,  A61K48/00 ,  C12N15/11 ,  C12N15/115

    CPC分类号： A61K9/51 ,  A61K48/0008 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2320/32

    摘要： The present invention generally relates to polymers and particles, such as nanoparticles. The particles and polymers generally include one or more buffering components. Additionally, the particles and polymers may include two or more components that impart useful properties (functionalities). The particles and polymers, for example, may include a buffering component and a degradable component. As described herein, the particles and polymers may also include a hydrophilic component and/or a cleavable bond component. The particles and polymers described herein have been found to be particularly effective when used for delivery of one or more agents, such as one or more pharmaceutical agents. Other aspects of the invention are directed to methods of using or administering such particles or polymers, kits involving such particles or polymers, and the like. The present invention also relates to particles containing a cleavable bond component and one or more fluorescence resonance energy transfer (FRET) pairs as well as methods of detecting the cleavage of the cleavable bond component of such particles.

    摘要翻译： 本发明一般涉及聚合物和颗粒，例如纳米颗粒。 颗粒和聚合物通常包括一种或多种缓冲组分。 此外，颗粒和聚合物可以包括赋予有用性质（功能）的两种或更多种组分。 颗粒和聚合物例如可以包括缓冲组分和可降解组分。 如本文所述，颗粒和聚合物还可以包括亲水组分和/或可裂解键组分。 已经发现本文所述的颗粒和聚合物在用于递送一种或多种试剂如一种或多种药剂时是特别有效的。 本发明的其它方面涉及使用或施用此类颗粒或聚合物的方法，涉及这种颗粒或聚合物的试剂等。 本发明还涉及含有可切割键组分和一种或多种荧光共振能量转移（FRET）对的颗粒以及检测这些颗粒的可裂解键组分的切割的方法。

    System for screening particles
    3.
    发明授权
    System for screening particles 有权
    颗粒筛选系统

    公开(公告)号：US09267937B2

    公开(公告)日：2016-02-23

    申请号：US12097118

    申请日：2006-12-15

    申请人： Omid C. Farokhzad ,  Aleksandar Filip Radovic-Moreno ,  Robert S. Langer

    发明人： Omid C. Farokhzad ,  Aleksandar Filip Radovic-Moreno ,  Robert S. Langer

    IPC分类号： C40B30/06 ,  G01N33/50 ,  B82Y5/00 ,  B82Y15/00 ,  A61K47/48

    CPC分类号： G01N33/5088 ,  A61K47/555 ,  A61K47/66 ,  A61K47/6891 ,  B82Y5/00 ,  B82Y15/00 ,  C40B30/06

    摘要： Screening of a library of particles in vivo and/or in vitro using Polyplex Iterative Combinatorial Optimization (PICO) allows for the design of particles for targeting a specific organ, tissue (e.g., cancer), or cell. Particles may, for example, include different targeting agents (e.g., aptamers or plurality of aptamers) on their surfaces, and the aptamer or aptamers may be evolved to provide better targeting of the particles. Libraries of particles are enriched in characteristics of particles that have been found to migrate to a tissue of interest, be taken up by cells, etc. The process may be repeated to engineer particles of a desired specificity or biological function.

    摘要翻译： 使用Polyplex迭代组合优化（PICO）在体内和/或体外筛选粒子库允许设计用于靶向特定器官，组织（例如癌症）或细胞的颗粒。 例如，颗粒可以在其表面上包括不同的靶向剂（例如，适体或多个适配体），并且适配体或适体可以进化以提供更好的颗粒靶向。 已经发现已经发现迁移到感兴趣的组织，被细胞吸收的颗粒的特征的颗粒的富集等。可以重复该过程来设计具有所需特异性或生物学功能的颗粒。

    Nicotine immunonanotherapeutics
    5.
    发明授权
    Nicotine immunonanotherapeutics 有权
    尼古丁免疫治疗

    公开(公告)号：US08591905B2

    公开(公告)日：2013-11-26

    申请号：US12428388

    申请日：2009-04-22

    申请人： Ulrich von Andrian ,  Omid C. Farokhzad ,  Frank Alexis ,  Matteo Iannacone ,  Pamela Basto ,  Jinjun Shi ,  Elliott Ashley Moseman ,  Robert S. Langer ,  Elena Tonti

    发明人： Ulrich von Andrian ,  Omid C. Farokhzad ,  Frank Alexis ,  Matteo Iannacone ,  Pamela Basto ,  Jinjun Shi ,  Elliott Ashley Moseman ,  Robert S. Langer ,  Elena Tonti

    IPC分类号： A61K39/00 ,  A61K47/00

    CPC分类号： A61K39/00

    摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof. For example, the present invention nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.

    摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供包含具有多个尼古丁部分的免疫表面的纳米载体。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。 例如，本发明能够引发免疫应答的纳米载体和抗尼古丁抗体的产生。

    Vaccine Nanotechnology
    9.
    发明申请
    Vaccine Nanotechnology 审中-公开
    疫苗纳米技术

    公开(公告)号：US20100233251A1

    公开(公告)日：2010-09-16

    申请号：US12681814

    申请日：2008-10-12

    申请人： Ulrich H. Von Andrian ,  Omid C. Farokhzad ,  Robert S. Langer ,  Tobias Junt ,  Ashley Moseman ,  Liangfang Zhang ,  Pamela Basto ,  Matteo Iannacone ,  Frank Alexis

    发明人： Ulrich H. Von Andrian ,  Omid C. Farokhzad ,  Robert S. Langer ,  Tobias Junt ,  Ashley Moseman ,  Liangfang Zhang ,  Pamela Basto ,  Matteo Iannacone ,  Frank Alexis

    IPC分类号： A61K9/127 ,  A61K9/14 ,  A61K39/00

    摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.

    摘要翻译： 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，在一些实施方案中，包含至少一种免疫调节剂，并且任选地包含至少一种靶向部分和任选的至少一种免疫刺激剂。 本发明提供包含本发明疫苗纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明疫苗纳米载体及其药物组合物的方法。 本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种本发明的疫苗纳米载体。