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公开(公告)号：US09333163B2
公开(公告)日：2016-05-10
申请号：US13122654
申请日：2009-10-06
申请人： Omid C. Farokhzad , Carolina Salvador-Morales , Weiwei Gao , Liangfang Zhang , Juliana M. Chan , Robert S. Langer
发明人： Omid C. Farokhzad , Carolina Salvador-Morales , Weiwei Gao , Liangfang Zhang , Juliana M. Chan , Robert S. Langer
CPC分类号： A61K47/48915 , A61K8/14 , A61K8/86 , A61K31/7088 , A61K39/0005 , A61K39/39 , A61K47/6911 , A61K47/6923 , A61K47/6929 , A61K47/6937 , A61K49/0065 , A61K49/0067 , A61K49/0093 , A61K2039/55516 , A61K2039/55555 , A61K2039/6093 , A61Q19/00 , B82Y5/00 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2320/32
摘要： This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides simple methods to create various particles that have multiple functionalized surface domains while allowing the use of a wide variety of diverse core structures. The multiple functionalized domains provide controllable particle binding and orientation, and controlled and sustained drug release profiles.
摘要翻译： 本公开涉及以受控马赛克图案显示多个功能化表面结构域的颗粒（例如，纳米颗粒和微粒）。 本公开还提供了简单的方法来产生具有多个功能化表面域的各种颗粒，同时允许使用各种不同的核心结构。 多个功能化区域提供可控的颗粒结合和取向，以及受控和持续的药物释放特征。
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公开(公告)号：US20110065807A1
公开(公告)日：2011-03-17
申请号：US12762348
申请日：2010-04-18
申请人： Aleksandar Filip Radovic-Moreno , Weiwei Gao , Archana Swami , Gershon Golomb , Robert S. Langer , Omid C. Farokhzad
发明人： Aleksandar Filip Radovic-Moreno , Weiwei Gao , Archana Swami , Gershon Golomb , Robert S. Langer , Omid C. Farokhzad
CPC分类号： A61K9/51 , A61K48/0008 , C12N15/111 , C12N15/115 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2320/32
摘要： The present invention generally relates to polymers and particles, such as nanoparticles. The particles and polymers generally include one or more buffering components. Additionally, the particles and polymers may include two or more components that impart useful properties (functionalities). The particles and polymers, for example, may include a buffering component and a degradable component. As described herein, the particles and polymers may also include a hydrophilic component and/or a cleavable bond component. The particles and polymers described herein have been found to be particularly effective when used for delivery of one or more agents, such as one or more pharmaceutical agents. Other aspects of the invention are directed to methods of using or administering such particles or polymers, kits involving such particles or polymers, and the like. The present invention also relates to particles containing a cleavable bond component and one or more fluorescence resonance energy transfer (FRET) pairs as well as methods of detecting the cleavage of the cleavable bond component of such particles.
摘要翻译： 本发明一般涉及聚合物和颗粒，例如纳米颗粒。 颗粒和聚合物通常包括一种或多种缓冲组分。 此外，颗粒和聚合物可以包括赋予有用性质（功能）的两种或更多种组分。 颗粒和聚合物例如可以包括缓冲组分和可降解组分。 如本文所述，颗粒和聚合物还可以包括亲水组分和/或可裂解键组分。 已经发现本文所述的颗粒和聚合物在用于递送一种或多种试剂如一种或多种药剂时是特别有效的。 本发明的其它方面涉及使用或施用此类颗粒或聚合物的方法，涉及这种颗粒或聚合物的试剂等。 本发明还涉及含有可切割键组分和一种或多种荧光共振能量转移（FRET）对的颗粒以及检测这些颗粒的可裂解键组分的切割的方法。
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公开(公告)号：US09532956B2
公开(公告)日：2017-01-03
申请号：US12762348
申请日：2010-04-18
申请人： Aleksandar Filip Radovic-Moreno , Weiwei Gao , Archana Swami , Gershon Golomb , Robert S. Langer , Omid C. Farokhzad
发明人： Aleksandar Filip Radovic-Moreno , Weiwei Gao , Archana Swami , Gershon Golomb , Robert S. Langer , Omid C. Farokhzad
CPC分类号： A61K9/51 , A61K48/0008 , C12N15/111 , C12N15/115 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2320/32
摘要： The present invention generally relates to polymers and particles, such as nanoparticles. The particles and polymers generally include one or more buffering components. Additionally, the particles and polymers may include two or more components that impart useful properties (functionalities). The particles and polymers, for example, may include a buffering component and a degradable component. As described herein, the particles and polymers may also include a hydrophilic component and/or a cleavable bond component. The particles and polymers described herein have been found to be particularly effective when used for delivery of one or more agents, such as one or more pharmaceutical agents. Other aspects of the invention are directed to methods of using or administering such particles or polymers, kits involving such particles or polymers, and the like. The present invention also relates to particles containing a cleavable bond component and one or more fluorescence resonance energy transfer (FRET) pairs as well as methods of detecting the cleavage of the cleavable bond component of such particles.
摘要翻译： 本发明一般涉及聚合物和颗粒，例如纳米颗粒。 颗粒和聚合物通常包括一种或多种缓冲组分。 此外，颗粒和聚合物可以包括赋予有用性质（功能）的两种或更多种组分。 颗粒和聚合物例如可以包括缓冲组分和可降解组分。 如本文所述，颗粒和聚合物还可以包括亲水组分和/或可裂解键组分。 已经发现本文所述的颗粒和聚合物在用于递送一种或多种试剂如一种或多种药剂时是特别有效的。 本发明的其它方面涉及使用或施用此类颗粒或聚合物的方法，涉及这种颗粒或聚合物的试剂等。 本发明还涉及含有可切割键组分和一种或多种荧光共振能量转移（FRET）对的颗粒以及检测这些颗粒的可裂解键组分的切割的方法。
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公开(公告)号：US20120156135A1
公开(公告)日：2012-06-21
申请号：US13122654
申请日：2009-10-06
申请人： Omid C. Farokhzad , Carolina Salvador-Morales , Weiwei Gao , Liangfang Zhang , Juliana M. Chan , Robert S. Langer
发明人： Omid C. Farokhzad , Carolina Salvador-Morales , Weiwei Gao , Liangfang Zhang , Juliana M. Chan , Robert S. Langer
CPC分类号： A61K47/48915 , A61K8/14 , A61K8/86 , A61K31/7088 , A61K39/0005 , A61K39/39 , A61K47/6911 , A61K47/6923 , A61K47/6929 , A61K47/6937 , A61K49/0065 , A61K49/0067 , A61K49/0093 , A61K2039/55516 , A61K2039/55555 , A61K2039/6093 , A61Q19/00 , B82Y5/00 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2320/32
摘要： This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides simple methods to create various particles that have multiple functionalized surface domains while allowing the use of a wide variety of diverse core structures. The multiple functionalized domains provide controllable particle binding and orientation, and controlled and sustained drug release profiles.
摘要翻译： 本公开涉及以受控马赛克图案显示多个功能化表面结构域的颗粒（例如，纳米颗粒和微粒）。 本公开还提供了简单的方法来产生具有多个功能化表面域的各种颗粒，同时允许使用各种不同的核心结构。 多个功能化区域提供可控的颗粒结合和取向，以及受控和持续的药物释放特征。
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