公开(公告)号：US20150174549A1

公开(公告)日：2015-06-25

申请号：US14523869

申请日：2014-10-25

申请人： Jong-Min Lim ,  Laura Marie Gilson ,  Sunandini Chopra ,  Omid Cameron Farokhzad ,  Rohit Nandkumar Karnik ,  Archana Swami

发明人： Jong-Min Lim ,  Laura Marie Gilson ,  Sunandini Chopra ,  Omid Cameron Farokhzad ,  Rohit Nandkumar Karnik ,  Archana Swami

IPC分类号： B01J19/06 ,  A61K9/51 ,  B01F15/02 ,  A61K31/713 ,  A61K47/48 ,  B01J19/26 ,  C01G49/02 ,  C09K11/02

CPC分类号： B01J19/06 ,  A61K9/5153 ,  A61K9/5192 ,  A61K31/713 ,  A61K47/59 ,  B01F5/045 ,  B01F5/0456 ,  B01F5/0458 ,  B01F2005/0025 ,  B01F2215/0431 ,  B01F2215/0459 ,  B01J19/0093 ,  B01J19/26 ,  B01J2219/00792 ,  B01J2219/00889 ,  C01G49/02 ,  C01P2004/04 ,  C01P2004/51 ,  C01P2004/64

摘要： A simple and versatile coaxial turbulent jet mixer can synthesize a range of nanoparticles at high throughput, while maintaining the advantages of homogeneity, reproducibility, and tunability that are normally accessible only in specialized microscale mixing devices. Rapid mixing down to a timescale of 7 ms can be achieved by controlling the Reynolds number, providing homogeneous and controllable environments for formation of nanoparticles, for example, by precipitation. The device fabrication does not require specialized machining, making it accessible for a wide range of biomedical laboratories.

摘要翻译： 简单且通用的同轴湍流喷射混合器可以以高通量合成一系列纳米颗粒，同时保持均匀性，再现性和可调性的优点，这些优点通常只能在专门的微米混合装置中使用。 通过控制雷诺数，可以快速混合到7 ms的时间范围，从而为形成纳米颗粒提供均匀和可控的环境，例如通过沉淀来实现。 设备制造不需要专门的加工，使其可以接触到广泛的生物医学实验室。

公开(公告)号：US20110065807A1

公开(公告)日：2011-03-17

申请号：US12762348

申请日：2010-04-18

申请人： Aleksandar Filip Radovic-Moreno ,  Weiwei Gao ,  Archana Swami ,  Gershon Golomb ,  Robert S. Langer ,  Omid C. Farokhzad

发明人： Aleksandar Filip Radovic-Moreno ,  Weiwei Gao ,  Archana Swami ,  Gershon Golomb ,  Robert S. Langer ,  Omid C. Farokhzad

IPC分类号： A61K47/30 ,  G01N21/76

CPC分类号： A61K9/51 ,  A61K48/0008 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2320/32

摘要： The present invention generally relates to polymers and particles, such as nanoparticles. The particles and polymers generally include one or more buffering components. Additionally, the particles and polymers may include two or more components that impart useful properties (functionalities). The particles and polymers, for example, may include a buffering component and a degradable component. As described herein, the particles and polymers may also include a hydrophilic component and/or a cleavable bond component. The particles and polymers described herein have been found to be particularly effective when used for delivery of one or more agents, such as one or more pharmaceutical agents. Other aspects of the invention are directed to methods of using or administering such particles or polymers, kits involving such particles or polymers, and the like. The present invention also relates to particles containing a cleavable bond component and one or more fluorescence resonance energy transfer (FRET) pairs as well as methods of detecting the cleavage of the cleavable bond component of such particles.

摘要翻译： 本发明一般涉及聚合物和颗粒，例如纳米颗粒。 颗粒和聚合物通常包括一种或多种缓冲组分。 此外，颗粒和聚合物可以包括赋予有用性质（功能）的两种或更多种组分。 颗粒和聚合物例如可以包括缓冲组分和可降解组分。 如本文所述，颗粒和聚合物还可以包括亲水组分和/或可裂解键组分。 已经发现本文所述的颗粒和聚合物在用于递送一种或多种试剂如一种或多种药剂时是特别有效的。 本发明的其它方面涉及使用或施用此类颗粒或聚合物的方法，涉及这种颗粒或聚合物的试剂等。 本发明还涉及含有可切割键组分和一种或多种荧光共振能量转移（FRET）对的颗粒以及检测这些颗粒的可裂解键组分的切割的方法。

公开(公告)号：US09532956B2

公开(公告)日：2017-01-03

申请号：US12762348

申请日：2010-04-18

申请人： Aleksandar Filip Radovic-Moreno ,  Weiwei Gao ,  Archana Swami ,  Gershon Golomb ,  Robert S. Langer ,  Omid C. Farokhzad

发明人： Aleksandar Filip Radovic-Moreno ,  Weiwei Gao ,  Archana Swami ,  Gershon Golomb ,  Robert S. Langer ,  Omid C. Farokhzad

IPC分类号： A61K47/30 ,  G01N21/76 ,  A61K9/51 ,  A61K48/00 ,  C12N15/11 ,  C12N15/115

CPC分类号： A61K9/51 ,  A61K48/0008 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2320/32

摘要： The present invention generally relates to polymers and particles, such as nanoparticles. The particles and polymers generally include one or more buffering components. Additionally, the particles and polymers may include two or more components that impart useful properties (functionalities). The particles and polymers, for example, may include a buffering component and a degradable component. As described herein, the particles and polymers may also include a hydrophilic component and/or a cleavable bond component. The particles and polymers described herein have been found to be particularly effective when used for delivery of one or more agents, such as one or more pharmaceutical agents. Other aspects of the invention are directed to methods of using or administering such particles or polymers, kits involving such particles or polymers, and the like. The present invention also relates to particles containing a cleavable bond component and one or more fluorescence resonance energy transfer (FRET) pairs as well as methods of detecting the cleavage of the cleavable bond component of such particles.

摘要翻译： 本发明一般涉及聚合物和颗粒，例如纳米颗粒。 颗粒和聚合物通常包括一种或多种缓冲组分。 此外，颗粒和聚合物可以包括赋予有用性质（功能）的两种或更多种组分。 颗粒和聚合物例如可以包括缓冲组分和可降解组分。 如本文所述，颗粒和聚合物还可以包括亲水组分和/或可裂解键组分。 已经发现本文所述的颗粒和聚合物在用于递送一种或多种试剂如一种或多种药剂时是特别有效的。 本发明的其它方面涉及使用或施用此类颗粒或聚合物的方法，涉及这种颗粒或聚合物的试剂等。 本发明还涉及含有可切割键组分和一种或多种荧光共振能量转移（FRET）对的颗粒以及检测这些颗粒的可裂解键组分的切割的方法。

公开(公告)号：US20100029750A1

公开(公告)日：2010-02-04

申请号：US12181798

申请日：2008-07-29

申请人： Kailash Chand GUPTA ,  Pradeep KUMAR ,  Archana SWAMI ,  Atul PATHAK

发明人： Kailash Chand GUPTA ,  Pradeep KUMAR ,  Archana SWAMI ,  Atul PATHAK

IPC分类号： A61K31/7088 ,  C08G73/00 ,  C12N15/12

CPC分类号： A61K31/7088 ,  A61K9/5146 ,  A61K48/00 ,  C08G73/0206 ,  C12N15/87

摘要： The present invention relates to a novel crosslinked polyethylenimine (PEI) nanoparticle based nucleic acid transfection agent wherein the crosslinker is having carbon chain in the range of C2 to C8, ranging between 3.27-19.8%, having the size of nanoparticle ranging between 20-600 nm and zeta potential ranging from +5 to 50 mV.

摘要翻译： 本发明涉及基于新型交联聚乙烯亚胺（PEI）纳米颗粒的核酸转染剂，其中交联剂具有在C2至C8范围内的碳链，范围在3.27-19.8％之间，纳米颗粒的尺寸范围在20-600之间 nm和zeta电位范围为+5至50mV。