发明授权
- 专利标题： Amphiphilic compound assisted nanoparticles for targeted delivery
- 专利标题（中）： 两亲化合物辅助纳米颗粒用于靶向递送
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申请号： US12573591申请日： 2009-10-05
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公开(公告)号： US09333179B2公开(公告)日： 2016-05-10
- 发明人: Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Frank Alexis , Robert S. Langer , Omid C. Farokhzad
- 申请人： Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Frank Alexis , Robert S. Langer , Omid C. Farokhzad
- 申请人地址： US MA Cambridge US MA Boston
- 专利权人： Massachusetts Institute of Technology,The Brigham and Women's Hospital, Inc.
- 当前专利权人： Massachusetts Institute of Technology,The Brigham and Women's Hospital, Inc.
- 当前专利权人地址： US MA Cambridge US MA Boston
- 代理机构： Pabst Patent Group LLP
- 主分类号： A61K9/51
- IPC分类号： A61K9/51 ; A61K47/48 ; B82Y5/00
摘要：
The present invention generally relates to nanoparticles with an amphiphilic component. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
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