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公开(公告)号：US20130028954A1
公开(公告)日：2013-01-31
申请号：US13630890
申请日：2012-09-28
CPC分类号： A61F13/00034 , A61F13/00029 , A61F13/00063 , A61F13/00991 , A61F2013/00106 , A61F2013/00463 , A61F2013/00472 , A61F2013/0054 , A61F2013/0091 , A61F2013/00927 , A61K38/4833 , A61L15/225 , A61L15/32 , A61L15/64 , A61L2400/04 , C08L89/00
摘要： The present invention relates to a hemostatic dressing which comprises a plurality of layers that contain resorbable materials and/or coagulation proteins. In particular, the invention includes dressings in which a layer of thrombin is sandwiched between a first and second layer of fibrinogen and wherein the layer of thrombin is not coextensive with the first and/or second layer of fibrinogen. The hemostatic dressings are useful for the treatment of wounded tissue.
摘要翻译： 本发明涉及一种止血敷料，其包含含有可再吸收材料和/或凝结蛋白质的多个层。 特别地，本发明包括敷料，其中一层凝血酶夹在第一和第二层纤维蛋白原之间，其中凝血酶层与纤维蛋白原的第一和/或第二层不共同延伸。 止血敷料可用于治疗伤口组织。
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公开(公告)号：US08679528B2
公开(公告)日：2014-03-25
申请号：US13630890
申请日：2012-09-28
CPC分类号： A61F13/00034 , A61F13/00029 , A61F13/00063 , A61F13/00991 , A61F2013/00106 , A61F2013/00463 , A61F2013/00472 , A61F2013/0054 , A61F2013/0091 , A61F2013/00927 , A61K38/4833 , A61L15/225 , A61L15/32 , A61L15/64 , A61L2400/04 , C08L89/00
摘要： The present invention relates to a hemostatic dressing which comprises a plurality of layers that contain resorbable materials and/or coagulation proteins. In particular, the invention includes dressings in which a layer of thrombin is sandwiched between a first and second layer of fibrinogen and wherein the layer of thrombin is not coextensive with the first and/or second layer of fibrinogen. The hemostatic dressings are useful for the treatment of wounded tissue.
摘要翻译： 本发明涉及一种止血敷料，其包含含有可再吸收材料和/或凝结蛋白质的多个层。 特别地，本发明包括敷料，其中一层凝血酶夹在第一和第二层纤维蛋白原之间，其中凝血酶层与纤维蛋白原的第一和/或第二层不共同延伸。 止血敷料可用于治疗伤口组织。
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公开(公告)号：US06762336B1
公开(公告)日：2004-07-13
申请号：US09890795
申请日：2002-03-22
申请人： Martin J. MacPhee , William H. Drohan , Dawson Beall , Stanley A. Friedman , David Tuthill , Valdislav Bayer
发明人： Martin J. MacPhee , William H. Drohan , Dawson Beall , Stanley A. Friedman , David Tuthill , Valdislav Bayer
IPC分类号： A61F1300
CPC分类号： A61L15/32 , A61L15/225 , A61L15/26 , A61L2400/04 , C08L89/00 , C08L67/04
摘要： The present invention relates to a haemostatic multilayer bandage that comprises preferably a thrombin layer between two fibrinogen layers. The dressing may contain other resorbable materials such as glycolic acid or lactic acid based polymers or copolymers. The inventive haemostatic bandage is useful for the treatment of wounded tissue.
摘要翻译： 本发明涉及一种止血性多层绷带，其优选地包含两个纤维蛋白原层之间的凝血酶层。 敷料可以含有其它可再吸收的材料，例如乙醇酸或乳酸基聚合物或共聚物。 本发明的止血绷带可用于治疗受伤组织。
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公开(公告)号：US20080176306A1
公开(公告)日：2008-07-24
申请号：US11843165
申请日：2007-08-22
IPC分类号： C12N13/00
CPC分类号： A61L2/0035 , A61L2/0029 , A61L2/0076 , A61L2202/22
摘要： Methods are disclosed for sterilizing biological products to reduce the level of active biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas and parasites.
摘要翻译： 公开了用于灭菌生物制品以降低活性生物污染物（例如病毒，细菌，酵母，霉菌，支原体和寄生虫）的水平的方法。
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公开(公告)号：US07229959B1
公开(公告)日：2007-06-12
申请号：US08479038
申请日：1995-06-07
申请人： William N. Drohan , Martin J. MacPhee , Hernan Nunez , Gene Liau , Wilson H. Burgess , Thomas Maciag
发明人： William N. Drohan , Martin J. MacPhee , Hernan Nunez , Gene Liau , Wilson H. Burgess , Thomas Maciag
IPC分类号： A61K38/36
CPC分类号： C12N5/069 , A61K31/25 , A61K31/337 , A61K31/4164 , A61K31/43 , A61K31/496 , A61K31/513 , A61K33/06 , A61K38/00 , A61K38/363 , A61K38/37 , A61K38/4833 , A61K45/06 , A61K47/42 , A61L15/32 , A61L24/0015 , A61L24/106 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/0085 , A61L27/34 , A61L27/507 , A61L2300/256 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/416 , A61L2300/418 , A61L2300/602 , C07K14/501 , C07K14/503 , C12N5/0062 , C12N2533/56 , C08L89/06 , C08L89/00 , C08L5/08 , A61K2300/00
摘要： This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antibody. The composition may be further supplemented with, for example, one or more analgesics, antimicrobial compositions, anticoagulants, antiproliferatives, anti-inflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like.
摘要翻译： 本发明提供补充和未补充的组织密封剂及其生产和使用方法。 公开了补充有至少一种抗体的组织密封剂。 该组合物可进一步补充有例如一种或多种止痛剂，抗微生物组合物，抗凝剂，抗增殖剂，抗炎化合物，细胞因子，细胞毒素，药物，生长因子，干扰素，激素，脂质，脱矿质骨或骨形态发生蛋白， 软骨诱导因子，寡核苷酸聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。
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6.发明授权Supplemented and unsupplemented tissue sealants, methods of their production and use 失效补充和未补充的组织密封剂，其生产和使用的方法公开(公告)号：US07189410B1
公开(公告)日：2007-03-13
申请号：US08474078
申请日：1995-06-07
申请人： William N. Drohan , Martin J. MacPhee , Wilson H. Burgess , Hernan Nunez , Manish Singh , Gene Liau , Thomas Maciag
发明人： William N. Drohan , Martin J. MacPhee , Wilson H. Burgess , Hernan Nunez , Manish Singh , Gene Liau , Thomas Maciag
CPC分类号： A61L15/32 , A61F13/0213 , A61F13/0253 , A61F13/0259 , A61F13/36 , A61F2013/00106 , A61F2013/00285 , A61F2013/00472 , A61F2013/0054 , A61F2013/00906 , A61F2013/00927 , A61F2013/00931 , A61K9/70
摘要： This invention provides a fibrin sealant bandage, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, anti-inflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Also disclosed are methods of preparing and/or using the unsupplemented or supplemented fibrin sealant bandage.
摘要翻译： 本发明提供一种纤维蛋白密封胶绷带，其中所述纤维蛋白封闭剂可补充至少一种选自例如一种或多种调节化合物，抗体，抗微生物组合物，止痛剂，抗凝剂，抗增殖剂，抗炎化合物，细胞因子， 细胞毒素，药物，生长因子，干扰素，激素，脂质，软化骨或骨形态发生蛋白，软骨诱导因子，寡核苷酸聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。 还公开了制备和/或使用未补充或补充的纤维蛋白密封胶绷带的方法。
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7.再颁专利Supplemented and unsupplemented tissue sealants, methods of their production and use 有权补充和未补充的组织密封剂，其生产和使用的方法公开(公告)号：USRE39298E1
公开(公告)日：2006-09-19
申请号：US10465860
申请日：2003-06-20
申请人： Martin J. MacPhee , William N. Drohan , Gene Liau , Hernan Nunez , Wilson H. Burgess , Thomas Maciag , Manish Singh
发明人： Martin J. MacPhee , William N. Drohan , Gene Liau , Hernan Nunez , Wilson H. Burgess , Thomas Maciag , Manish Singh
CPC分类号： A61K38/363 , A61B17/00491 , A61B2017/00495 , A61F2002/2817 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61L24/0015 , A61L24/106 , A61L26/0042 , A61L26/0066 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2300/602 , C12N5/0062 , C12N5/069 , C12N2533/56 , A61K2300/00
摘要： This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, antiproliferatives, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Further provided are methods of using the site-specific supplemented tissue sealants, including preparation of a biomaterial.
摘要翻译： 本发明提供了补充组织密封剂的局部递送的方法，其中补充的组织密封剂包含至少一种选自一种或多种抗体，止痛剂，抗凝剂，抗炎化合物，抗微生物组合物，抗增殖剂，细胞因子，细胞毒素， 药物，生长因子，干扰素，激素，脂质，软化骨或骨形态发生蛋白，软骨诱导因子，寡聚体聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。 还提供了使用位点特异性补充组织密封剂的方法，包括制备生物材料。
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公开(公告)号：US06559119B1
公开(公告)日：2003-05-06
申请号：US08486048
申请日：1995-06-07
申请人： Willson H. Burgess , Howard P. Greisler , William N. Drohan , Thomas Maciag , Martin J. MacPhee
发明人： Willson H. Burgess , Howard P. Greisler , William N. Drohan , Thomas Maciag , Martin J. MacPhee
IPC分类号： A61K3836
CPC分类号： A61K38/37 , A61K31/513 , A61K31/65 , A61K33/06 , A61K33/14 , A61K35/19 , A61K38/00 , A61K38/1808 , A61K38/1841 , A61K38/363 , A61K38/39 , A61K38/4833 , A61K45/06 , A61K47/42 , A61L15/32 , A61L24/0015 , A61L24/106 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/0085 , A61L27/34 , A61L27/507 , A61L2300/256 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/416 , A61L2300/418 , A61L2300/602 , C07K14/501 , C07K14/503 , C12N5/0062 , C12N5/069 , C12N2533/56 , C08L89/06 , C08L89/00 , C08L5/08 , A61K2300/00
摘要： This invention provides methods for the preparation of a tissue sealant-treated biomaterial, wherein the tissue sealant used in the method comprises at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, antiproliferatives, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Further provided are the biomaterial prepared therefrom, including vascular grafts.
摘要翻译： 本发明提供了用于制备组织密封剂处理的生物材料的方法，其中用于该方法的组织密封剂包含至少一种选自一种或多种抗体，止痛剂，抗凝剂，抗炎化合物，抗微生物组合物，抗增生剂 ，细胞因子，细胞毒素，药物，生长因子，干扰素，激素，脂质，软化骨或骨形态发生蛋白，软骨诱导因子，寡核苷酸聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。 还提供了由其制备的生物材料，包括血管移植物。
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公开(公告)号：US06783968B2
公开(公告)日：2004-08-31
申请号：US09960704
申请日：2001-09-24
IPC分类号： A01N6300
CPC分类号： C12N13/00 , C12N9/2465 , C12Y302/01022
摘要： Methods are disclosed for sterilizing preparations of glycosidases to reduce the level therein of one or more active biological contaminants or pathogens, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, single or multicellular parasites, prions or similar agents responsible, alone or in combination, for TSEs. These methods involve sterilizing preparations of glycosidases, such as alpha-glucosidase or alpha-galactosidase, with irradiation.
摘要翻译： 公开了消除糖苷酶制剂的方法以降低其中一种或多种活性生物污染物或病原体如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素原，尿细菌，衣原体，立克次体），酵母中的水平 ，霉菌，单细胞或多细胞寄生虫，朊病毒或类似物质，单独或组合负责TSE。 这些方法包括用照射消毒糖苷酶（例如α-葡糖苷酶或α-半乳糖苷酶）的制剂。
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公开(公告)号：US06124273A
公开(公告)日：2000-09-26
申请号：US960555
申请日：1997-10-13
申请人： William N. Drohan , Martin J. MacPhee , Shirley I. Miekka , Manish S. Singh , Clive Elson , John R. Taylor, Jr.
发明人： William N. Drohan , Martin J. MacPhee , Shirley I. Miekka , Manish S. Singh , Clive Elson , John R. Taylor, Jr.
IPC分类号： A61K9/00 , A61K9/20 , A61K38/00 , A61K38/18 , A61K38/22 , A61K38/37 , A61K38/43 , A61K38/48 , A61K45/00 , A61K47/36 , A61L26/00 , A61P7/00 , A61P17/00 , C08B37/08 , C08L5/08 , A61K31/73
CPC分类号： A61L27/507 , A61K38/18 , A61K38/37 , A61K38/4846 , A61K47/36 , A61K9/0014 , A61K9/0019 , A61K9/205 , A61L26/0023 , A61L26/0047 , A61L26/0066 , A61L26/008 , C08B37/003 , C08L5/08 , A61L2300/252 , A61L2300/406 , A61L2300/414 , A61L2300/418 , A61L2300/45 , A61L2300/602
摘要： This invention is directed to the preparation and utilization of supplemented chitin hydrogels, such as chitosan hydrogels. Further provided are biomaterials comprising same. The particular supplement delivered by the chitin hydrogel is selected as a function of its intended use. In one embodiment, this invention provides a composition of matter, comprising a chitin hydrogel or chitin-derived hydrogel, wherein the hydrogel does not inhibit full-thickness skin wound healing.
摘要翻译： 本发明涉及补充的几丁质水凝胶如壳聚糖水凝胶的制备和利用。 进一步提供包含其的生物材料。 作为其预期用途的函数选择由甲壳素水凝胶递送的特定补充物。 在一个实施方案中，本发明提供了一种物质组合物，其包含壳多糖水凝胶或几丁质衍生的水凝胶，其中所述水凝胶不抑制全层皮肤伤口愈合。
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