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公开(公告)号：US20030077615A1
公开(公告)日：2003-04-24
申请号：US10124884
申请日：2002-04-18
IPC分类号： C12Q001/68 , G06F019/00 , G01N033/48 , G01N033/50 , G06K009/00 , C12M001/34
CPC分类号： C12Q1/6874 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00648 , B01J2219/00659 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2200/10 , B01L2300/0877 , B01L2400/0403 , B01L2400/0475 , B01L2400/0622 , B01L2400/0644 , C40B60/14 , G01N15/1456 , G01N15/1475 , G01N15/1484 , G01N21/253 , G01N2015/0015 , G01N2015/149 , C12Q2565/518 , C12Q2525/161 , C12Q2521/313 , C12Q2525/191
摘要： Abstract An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.
摘要翻译： 摘要提供了一种用于同时分析锚定在微粒上的多种分析物的装置和系统。 每个具有单一类型分析物的均匀群体的微粒被布置为在流动室内部基本上固定的平面阵列，其中分析过程的步骤通过将一系列处理试剂通过流体系统递送到微粒进行， 微处理器控制。 响应于这样的处理步骤，在每个微粒的表面产生光信号，其特征在于微粒携带的分析物与递送的处理试剂之间的相互作用。 通过收集和记录由平面阵列中的所有微粒产生的光学信号的图像来同时分析多个分析物。 本发明的一个关键特征是在分析过程中由平面阵列中的每个微粒产生的光信号序列的相关性。
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公开(公告)号：US20020061529A1
公开(公告)日：2002-05-23
申请号：US09908131
申请日：2001-07-17
IPC分类号： C12Q001/68 , G06K009/00 , C12M001/34
CPC分类号： G01N21/253 , B01J2219/00274 , B01L3/5027 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2200/10 , B01L2300/0877 , B01L2400/0403 , B01L2400/0475 , B01L2400/0622 , B01L2400/0644 , G01N2015/144 , G01N2015/1452 , G01N2035/00158 , Y10S435/81 , Y10T436/13 , Y10T436/143333
摘要： An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.
摘要翻译： 提供了一种用于同时分析锚定到微粒的多个分析物的装置和系统。 每个具有单一类型分析物的均匀群体的微粒被布置为在流动室内部基本上固定的平面阵列，其中分析过程的步骤通过将一系列处理试剂通过流体系统递送到微粒来进行， 微处理器控制。 响应于这样的处理步骤，在每个微粒的表面产生光信号，其特征在于微粒携带的分析物与递送的处理试剂之间的相互作用。 通过收集和记录由平面阵列中的所有微粒产生的光学信号的图像来同时分析多个分析物。 本发明的一个关键特征是在分析过程中由平面阵列中的每个微粒产生的光信号序列的相关性。
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公开(公告)号：US20020137052A1
公开(公告)日：2002-09-26
申请号：US09907795
申请日：2001-07-17
IPC分类号： C12Q001/68 , C12M001/34 , G01J003/42
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00648 , B01J2219/00659 , B01L3/5027 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2200/10 , B01L2300/0877 , B01L2300/1822 , B01L2400/0403 , B01L2400/0475 , B01L2400/0622 , B01L2400/0644 , C12Q1/6874 , C40B60/14 , G01N15/1456 , G01N15/1475 , G01N15/1484 , G01N21/05 , G01N21/253 , G01N21/6428 , G01N2015/0015 , G01N2015/149 , G01N2021/0346 , C12Q2565/518 , C12Q2521/313 , C12Q2525/191 , C12Q2525/161
摘要： An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.
摘要翻译： 提供了一种用于同时分析锚定到微粒的多个分析物的装置和系统。 每个具有单一类型分析物的均匀群体的微粒被布置为在流动室内部基本上固定的平面阵列，其中分析过程的步骤通过将一系列处理试剂通过流体系统递送到微粒进行， 微处理器控制。 响应于这样的处理步骤，在每个微粒的表面上产生光信号，其特征在于由微粒携带的分析物与递送的处理试剂之间的相互作用。多个分析物同时通过收集和记录 由平面阵列中的所有微粒产生的光信号。 本发明的一个关键特征是在分析过程中由平面阵列中的每个微粒产生的光信号序列的相关性。
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公开(公告)号：US20020051992A1
公开(公告)日：2002-05-02
申请号：US09908130
申请日：2001-07-17
IPC分类号： C12Q001/68 , G06K009/00 , C12M001/34
CPC分类号： C12Q1/6874 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00648 , B01J2219/00659 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2200/10 , B01L2300/0877 , B01L2400/0403 , B01L2400/0475 , B01L2400/0622 , B01L2400/0644 , C40B60/14 , G01N15/1456 , G01N15/1475 , G01N15/1484 , G01N21/253 , G01N2015/0015 , G01N2015/149 , C12Q2565/518 , C12Q2525/161 , C12Q2521/313 , C12Q2525/191
摘要： An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.
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