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公开(公告)号：US09139667B2
公开(公告)日：2015-09-22
申请号：US13763066
申请日：2013-02-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Steven Menchen , Alan Blanchard , Luisa Andruzzi , Shaheer Khan , Dmitriy Gremyachinskiy , Alfred Lui , Craig Stolarczyk , Tanya Sokolsky , Prasanna Krishnan Thwar
CPC classification number: C12Q1/6876 , C08F8/40 , C12Q1/6834 , C12Q2523/101 , C12Q2563/149 , C12Q2565/119
Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
Abstract translation: 缀合基质的方法包括将与生物分子相关的抗衡离子与亲脂抗衡离子交换以形成生物分子复合物，将生物分子复合物分散在非水溶剂中，并在非水溶剂存在下将生物分子复合物偶联到底物 。
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公开(公告)号：US10724094B2
公开(公告)日：2020-07-28
申请号：US15945348
申请日：2018-04-04
Applicant: Life Technologies Corporation
Inventor： Steven M. Menchen , Alan Blanchard , Luisa Andruzzi , Shaheer H. Khan , Dmitriy Gremyachinskiy , Alfred Lui , Craig Stolarczyk , Tanya Sokolsky , Prasanna Krishnan Thwar
IPC: C12Q1/6876 , C08F8/40 , C12Q1/6834
Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
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公开(公告)号：US10246533B2
公开(公告)日：2019-04-02
申请号：US14970192
申请日：2015-12-15
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofslokken Kjus , Astrid Evenroed Molteberg , Diem Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F130/08 , C08F6/24 , C07F7/18 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32 , C08F8/34 , C12Q1/686 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20 , C08F8/12
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of monomer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US10947333B2
公开(公告)日：2021-03-16
申请号：US16259963
申请日：2019-01-28
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , Muhammed Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F230/08 , C08F220/58 , C08F8/34 , C08F8/32 , C08F8/12 , C08F2/20 , C08F130/08 , C08F6/24 , C07F7/18 , C12Q1/686 , C08F2/26 , C08F222/38 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US09938577B2
公开(公告)日：2018-04-10
申请号：US14855705
申请日：2015-09-16
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Steven M. Menchen , Alan Blanchard , Luisa Andruzzi , Shaheer H. Khan , Dmitriy Gremyachinskiy , Alfred Lui , Craig Stolarczyk , Tanya Sokolsky , Prasanna Krishnan Thwar
CPC classification number: C12Q1/6876 , C08F8/40 , C12Q1/6834 , C12Q2523/101 , C12Q2563/149 , C12Q2565/119
Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
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Patent Agency Ranking
公开(公告)号：US20160002723A1
公开(公告)日：2016-01-07
申请号：US14855705
申请日：2015-09-16
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Steven M. MENCHEN , Alan Blanchard , Luisa Andruzzi , Shaheer H. Khan , Dmitriy Gremyachinskiy , Alfred Lui , Craig Stolarczyk , Tanya Sokolsky , Prasanna Krishnan Thwar
IPC: C12Q1/68
CPC classification number: C12Q1/6876 , C08F8/40 , C12Q1/6834 , C12Q2523/101 , C12Q2563/149 , C12Q2565/119
Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
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公开(公告)号：US09139666B2
公开(公告)日：2015-09-22
申请号：US14082368
申请日：2013-11-18
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete I. Modahl , Nini H. Kjus , Astrid E. Molteberg , Diem Tran , Jo Aaserud , Talha M. Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C12Q1/68 , C08F8/34 , C07F7/18 , C08F6/24 , C08F130/08 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
Abstract translation: 形成颗粒的方法包括在水性悬浮液中的分散相中聚合具有疏水保护基团的亲水性单体的多个聚合单元，从而形成包含多个疏水保护基团的聚合物颗粒。 该方法还包括将聚合物颗粒转化为亲水性颗粒。
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公开(公告)号：US20130210991A1
公开(公告)日：2013-08-15
申请号：US13762941
申请日：2013-02-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Geir Fonnum , Grete Modahl , Nini Kjus , Astrid Evenroed Molteberg , Diem Tran , Jo Aaserud , M. Talha Gokmen , Steven Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F6/24
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
Abstract translation: 形成颗粒的方法包括在水性悬浮液中的分散相中聚合具有疏水保护基团的亲水性单体的多个聚合单元，从而形成包含多个疏水保护基团的聚合物颗粒。 该方法还包括将聚合物颗粒转化为亲水性颗粒。
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公开(公告)号：US12122859B2
公开(公告)日：2024-10-22
申请号：US18101785
申请日：2023-01-26
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F230/08 , C07F7/18 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F130/08 , C08F220/58 , C08F222/38 , C08J9/20 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/414 , C08F220/60
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F222/385 , C08F230/085 , C08J9/20 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , C08F220/603 , C08F2800/20 , C08J2343/04 , Y10T428/2982 , C08F8/12 , C08F257/02 , C08F8/34 , C08F8/12 , C08F257/02 , C12Q1/686 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543 , C08F257/02 , C08F230/085 , C08F8/12 , C08F230/085 , C08F8/34 , C08F8/12 , C08F230/085 , C08F230/085 , C08F230/085 , C08F230/085 , C08F230/085 , C08F220/603 , C08F230/085 , C08F212/36 , C08F230/085 , C08F222/102
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US11702696B2
公开(公告)日：2023-07-18
申请号：US16938222
申请日：2020-07-24
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Steven M. Menchen , Alan Blanchard , Luisa Andruzzi , Shaheer Khan , Dmitriy Gremyachinskiy , Alfred Lui , Craig Stolarczyk , Tanya Sokolsky , Prasanna Krishnan Thwar
IPC: C12Q1/6876 , C08F8/40 , C12Q1/6834
CPC classification number: C12Q1/6876 , C08F8/40 , C12Q1/6834 , C12Q1/6834 , C12Q2523/101 , C12Q2563/149 , C12Q2565/119
Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
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