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公开(公告)号：US09139667B2
公开(公告)日：2015-09-22
申请号：US13763066
申请日：2013-02-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Steven Menchen , Alan Blanchard , Luisa Andruzzi , Shaheer Khan , Dmitriy Gremyachinskiy , Alfred Lui , Craig Stolarczyk , Tanya Sokolsky , Prasanna Krishnan Thwar
CPC classification number: C12Q1/6876 , C08F8/40 , C12Q1/6834 , C12Q2523/101 , C12Q2563/149 , C12Q2565/119
Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
Abstract translation: 缀合基质的方法包括将与生物分子相关的抗衡离子与亲脂抗衡离子交换以形成生物分子复合物，将生物分子复合物分散在非水溶剂中，并在非水溶剂存在下将生物分子复合物偶联到底物 。
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Patent Agency Ranking
公开(公告)号：US10724094B2
公开(公告)日：2020-07-28
申请号：US15945348
申请日：2018-04-04
Applicant: Life Technologies Corporation
Inventor： Steven M. Menchen , Alan Blanchard , Luisa Andruzzi , Shaheer H. Khan , Dmitriy Gremyachinskiy , Alfred Lui , Craig Stolarczyk , Tanya Sokolsky , Prasanna Krishnan Thwar
IPC: C12Q1/6876 , C08F8/40 , C12Q1/6834
Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
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公开(公告)号：US11702696B2
公开(公告)日：2023-07-18
申请号：US16938222
申请日：2020-07-24
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Steven M. Menchen , Alan Blanchard , Luisa Andruzzi , Shaheer Khan , Dmitriy Gremyachinskiy , Alfred Lui , Craig Stolarczyk , Tanya Sokolsky , Prasanna Krishnan Thwar
IPC: C12Q1/6876 , C08F8/40 , C12Q1/6834
CPC classification number: C12Q1/6876 , C08F8/40 , C12Q1/6834 , C12Q1/6834 , C12Q2523/101 , C12Q2563/149 , C12Q2565/119
Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
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公开(公告)号：US20130211006A1
公开(公告)日：2013-08-15
申请号：US13763066
申请日：2013-02-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Steven Menchen , Alan Blanchard , Luisa Andruzzi , Shaheer Khan , Dmitriy Gremyachinskiy , Alfred Lui , Craig Stolarczyk , Tanya Sokolsky
IPC: C08F8/40
CPC classification number: C12Q1/6876 , C08F8/40 , C12Q1/6834 , C12Q2523/101 , C12Q2563/149 , C12Q2565/119
Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
Abstract translation: 缀合基质的方法包括将与生物分子相关的抗衡离子与亲脂抗衡离子交换以形成生物分子复合物，将生物分子复合物分散在非水溶剂中，并在非水溶剂存在下将生物分子复合物偶联到底物 。
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公开(公告)号：US09938577B2
公开(公告)日：2018-04-10
申请号：US14855705
申请日：2015-09-16
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Steven M. Menchen , Alan Blanchard , Luisa Andruzzi , Shaheer H. Khan , Dmitriy Gremyachinskiy , Alfred Lui , Craig Stolarczyk , Tanya Sokolsky , Prasanna Krishnan Thwar
CPC classification number: C12Q1/6876 , C08F8/40 , C12Q1/6834 , C12Q2523/101 , C12Q2563/149 , C12Q2565/119
Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
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公开(公告)号：US20160002723A1
公开(公告)日：2016-01-07
申请号：US14855705
申请日：2015-09-16
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Steven M. MENCHEN , Alan Blanchard , Luisa Andruzzi , Shaheer H. Khan , Dmitriy Gremyachinskiy , Alfred Lui , Craig Stolarczyk , Tanya Sokolsky , Prasanna Krishnan Thwar
IPC: C12Q1/68
CPC classification number: C12Q1/6876 , C08F8/40 , C12Q1/6834 , C12Q2523/101 , C12Q2563/149 , C12Q2565/119
Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
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