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31 条记录 (耗时 0.028 秒)

    Metabolic Downregulation for Cell Survival
    1.
    发明申请
    Metabolic Downregulation for Cell Survival 审中-公开
    细胞存活的代谢下调

    公开(公告)号：US20130281400A1

    公开(公告)日：2013-10-24

    申请号：US13882433

    申请日：2011-11-10

    申请人： James J. Yoo ,  Sang Jin Lee ,  Jaehyun Kim ,  Anthony Atala

    发明人： James J. Yoo ,  Sang Jin Lee ,  Jaehyun Kim ,  Anthony Atala

    IPC分类号： C12N5/071

    CPC分类号： C12N5/0658 ,  C12N2500/02

    摘要： The present provides a system and method of maintaining and/or increasing cell viability by downregulating cellular metabolic rate under hypoxic conditions. The present invention also relates to a system and method of prolonging the survival of implanted cells that are under hypoxic condition until host neovascularization is achieved.

    摘要翻译： 本发明提供通过在低氧条件下下调细胞代谢速率来维持和/或增加细胞存活力的系统和方法。 本发明还涉及延长在缺氧条件下进行宿主新生血管形成的植入细胞的存活的系统和方法。

    TISSUE EXPANDER
    2.
    发明申请
    TISSUE EXPANDER 有权
    组织膨胀机

    公开(公告)号：US20110172683A1

    公开(公告)日：2011-07-14

    申请号：US12986771

    申请日：2011-01-07

    申请人： James J. Yoo ,  Anthony Atala ,  Paul Scarpinato ,  Sang Jin Lee ,  Mitchell Ladd

    发明人： James J. Yoo ,  Anthony Atala ,  Paul Scarpinato ,  Sang Jin Lee ,  Mitchell Ladd

    IPC分类号： A61B17/00

    CPC分类号： A61B17/322 ,  A61B90/02 ,  A61B2017/00969 ,  A61B2017/3225

    摘要： Provided herein is a tissue stretching device including a tissue clamping member defining an area in a Z plane, wherein the tissue clamping member is configured to hold tissue parallel to the Z plane. Methods of use of the tissue stretching device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods of treatment making use of the same.

    摘要翻译： 本文提供了一种组织拉伸装置，其包括限定Z平面中的区域的组织夹持构件，其中组织夹持构件被构造成保持平行于Z平面的组织。 还提供了使用组织拉伸装置拉伸组织以及培养有组织的组织的方法。 还提供了通过这些方法生产的拉伸和/或培养的组织，以及使用它们的治疗方法。

    Tissue expander
    3.
    发明授权
    Tissue expander 有权
    组织扩张器

    公开(公告)号：US09585688B2

    公开(公告)日：2017-03-07

    申请号：US12986771

    申请日：2011-01-07

    申请人： James J. Yoo ,  Anthony Atala ,  Paul Scarpinato ,  Sang Jin Lee ,  Mitchell Ladd

    发明人： James J. Yoo ,  Anthony Atala ,  Paul Scarpinato ,  Sang Jin Lee ,  Mitchell Ladd

    IPC分类号： A61B17/322 ,  A61B17/00

    CPC分类号： A61B17/322 ,  A61B90/02 ,  A61B2017/00969 ,  A61B2017/3225

    摘要： Provided herein is a tissue stretching device including a tissue clamping member defining an area in a Z plane, wherein the tissue clamping member is configured to hold tissue parallel to the Z plane. Methods of use of the tissue stretching device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods of treatment making use of the same.

    摘要翻译： 本文提供了一种组织拉伸装置，其包括限定Z平面中的区域的组织夹持构件，其中组织夹持构件被构造成保持平行于Z平面的组织。 还提供了使用组织拉伸装置拉伸组织以及培养有组织的组织的方法。 还提供了通过这些方法生产的拉伸和/或培养的组织，以及使用它们的治疗方法。

    INTEGRATED ORGAN AND TISSUE PRINTING METHODS, SYSTEM AND APPARATUS
    4.
    发明申请
    INTEGRATED ORGAN AND TISSUE PRINTING METHODS, SYSTEM AND APPARATUS 审中-公开
    一体化组织和组织印刷方法，系统和装置

    公开(公告)号：US20120089238A1

    公开(公告)日：2012-04-12

    申请号：US13267448

    申请日：2011-10-06

    申请人： Hyun-Wook Kang ,  Sang Jin Lee ,  Anthony Atala ,  James J. Yoo

    发明人： Hyun-Wook Kang ,  Sang Jin Lee ,  Anthony Atala ,  James J. Yoo

    IPC分类号： A61F2/02 ,  B05C11/00 ,  B05D1/00

    CPC分类号： B29C64/112 ,  A61K35/12 ,  A61L27/20 ,  A61L27/222 ,  A61L27/225 ,  A61L27/26 ,  A61L27/38 ,  A61L27/52 ,  B29C64/124 ,  B29C64/386 ,  B29C64/393 ,  B29K2105/0005 ,  B29K2267/04 ,  B29L2031/7532 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  B33Y80/00 ,  C12M21/08 ,  C12M23/50 ,  C12M33/00 ,  C08L5/08

    摘要： A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.

    摘要翻译： 一种制造器官或组织的方法包括：（a）提供含有结构支持聚合物的第一分配器和包含含活细胞组合物的第二分配器; （b）从所述第一和第二分配器在所述支撑件上沉积一层，所述层包括结构支撑聚合物和所述含细胞的组合物; 然后（c）重复地重复所述沉积步骤多次以形成多个层，其中每个所述层中的单独和离散区域包括所述支撑聚合物或所述含细胞组合物中的一种或另一种， 从而产生提供包含结构支持区域和含细胞区域的复合三维结构。 还描述了用于实施由该方法生产的方法和复合产品的装置。

    ENCAPSULATED CELLS FOR HORMONE REPLACEMENT THERAPY
    7.
    发明申请
    ENCAPSULATED CELLS FOR HORMONE REPLACEMENT THERAPY 审中-公开
    用于激素替代治疗的包封细胞

    公开(公告)号：US20140127308A1

    公开(公告)日：2014-05-08

    申请号：US14002504

    申请日：2012-02-21

    申请人： Emmanuel Opara ,  James J. Yoo ,  Justin M. Saul ,  Sittadjody Sivanandane ,  Anthony Atala

    发明人： Emmanuel Opara ,  James J. Yoo ,  Justin M. Saul ,  Sittadjody Sivanandane ,  Anthony Atala

    IPC分类号： A61K35/54 ,  A61K9/50

    CPC分类号： A61K35/54 ,  A61K9/167 ,  A61K9/5036 ,  A61K9/5073 ,  A61K31/565 ,  A61K31/57 ,  A61K2300/00

    摘要： A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.

    摘要翻译： 描述了包含微胶囊的组合物，包含活哺乳动物卵巢颗粒细胞和活哺乳动物卵巢细胞的微胶囊。 在一些实施方案中，颗粒细胞和细胞被包含在组合物中的分离的微胶囊中; 在一些实施方案中，颗粒细胞和细胞在组合物中一起包含在相同的微胶囊中。组合物可用于雌激素，并且任选地也可用于孕酮，递送，因此优选是游离的或基本上不含卵母细胞。 还描述了使用它们的方法和含有它们的药物制剂。

    Tissue engineered female reproductive organs
    8.
    发明授权
    Tissue engineered female reproductive organs 失效
    组织工程女性生殖器官

    公开(公告)号：US07806937B2

    公开(公告)日：2010-10-05

    申请号：US10298198

    申请日：2002-11-15

    申请人： Anthony Atala ,  James J. Yoo

    发明人： Anthony Atala ,  James J. Yoo

    IPC分类号： C12N5/00

    CPC分类号： A61L27/3604 ,  A61K35/12 ,  A61L27/18 ,  A61L27/3679 ,  A61L27/38 ,  A61L2430/22 ,  C12N5/0068 ,  C12N5/0697 ,  C12N2500/84 ,  C12N2501/11 ,  C12N2502/1347 ,  C12N2502/243 ,  C12N2533/40 ,  C08L67/04

    摘要： The invention is directed to compositions and methods for reconstructing artificial female reproductive organs. The constructs and methods of the invention can be used for ameliorating congenital malformations and disorders of female reproductive tract using tissue engineered female reproductive organs, such as the uterus, vagina, cervix, and fallopian tubes. These tissue engineered female reproductive organs can be generated by perfusing cultured cell populations derived from cells of the female reproductive tissues, such as uterine, vaginal, cervical, fallopian tube epithelial cells as well as smooth muscle cells.

    摘要翻译： 本发明涉及用于重建人造女性生殖器官的组合物和方法。 本发明的构建和方法可用于使用组织工程化的女性生殖器官如子宫，阴道，子宫颈和输卵管改善先天性畸形和女性生殖道障碍。 这些组织工程化的雌性生殖器官可以通过灌注来自雌性生殖组织的细胞的培养细胞群，如子宫，阴道，子宫颈，输卵管上皮细胞以及平滑肌细胞产生。

    INKJET GENE PRINTING
    9.
    发明申请
    INKJET GENE PRINTING 有权
    INKJET基因印刷

    公开(公告)号：US20100160183A1

    公开(公告)日：2010-06-24

    申请号：US12663020

    申请日：2008-06-06

    申请人： Tao Xu ,  James J. Yoo ,  Anthony Atala

    发明人： Tao Xu ,  James J. Yoo ,  Anthony Atala

    IPC分类号： C12N15/87 ,  C12N5/00 ,  C40B50/14 ,  C40B60/14

    CPC分类号： C12N15/895 ,  A61K31/713 ,  C12N15/63 ,  C12N15/87 ,  C12N15/89

    摘要： Provided herein are methods and apparatuses for transfecting a cell with a compound of interest by stressing the cell, e.g. with shear stress. The compound of interest may be nucleic acids, proteins, molecules, nanoparticles, drugs, etc., or any combination thereof. Methods of printing cells with an inkjet printing device are also provided, wherein at least a portion of viable cells (preferably at least 1%) are transfected with a compound of interest. Preferably, at least 25% of the cells are viable after printing. In addition, methods of forming an array of viable cells are provided wherein at least a portion of the viable printed cells (preferably at least 1%) are transfected with at least one compound of interest.

    摘要翻译： 本文提供了用于通过施加细胞来转染具有感兴趣的化合物的细胞的方法和装置，例如， 具有剪切应力。 感兴趣的化合物可以是核酸，蛋白质，分子，纳米颗粒，药物等，或其任何组合。 还提供了用喷墨印刷装置印刷细胞的方法，其中至少一部分活细胞（优选至少1％）用感兴趣的化合物转染。 优选地，至少25％的细胞在印刷后是活的。 此外，提供形成活细胞阵列的方法，其中至少一部分活的印刷细胞（优选至少1％）用至少一种目标化合物转染。

    SELECTIVE CELL THERAPY FOR THE TREATMENT OF RENAL FAILURE
    10.
    发明申请
    SELECTIVE CELL THERAPY FOR THE TREATMENT OF RENAL FAILURE 审中-公开
    用于治疗失败的选择性细胞治疗

    公开(公告)号：US20100104544A1

    公开(公告)日：2010-04-29

    申请号：US12618179

    申请日：2009-11-13

    申请人： Anthony Atala ,  James J. Yoo

    发明人： Anthony Atala ,  James J. Yoo

    IPC分类号： A61K35/12 ,  C12N5/071 ,  A61P13/12 ,  A61P7/06 ,  C12N5/02

    CPC分类号： C12N5/0686 ,  A61K35/12 ,  A61K35/22 ,  C12N2500/02

    摘要： Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein the cells have been expanded in vitro. The kidney cells preferably produce erythropoietin (EPO). The kidney cells may also be selected based upon EPO production. Methods of producing an isolated population of EPO producing cells are also provided, and methods of treating a kidney disease resulting in decreased EPO production in a patient in need thereof are provided, including administering the population to the patient, whereby the cells express EPO in vivo in an oxygen tension-dependent manner.

    摘要翻译： 本文提供了从分化的肾细胞收获的分离的肾细胞群体，其中细胞已经在体外扩增。 肾细胞优选产生促红细胞生成素（EPO）。 也可以基于EPO生产来选择肾细胞。 还提供了产生分离的EPO产生细胞群体的方法，并且提供了治疗有需要的患者中导致EPO产生减少的肾脏疾病的方法，包括向患者施用群体，由此细胞体内表达EPO 以氧依赖于张力的方式。