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公开(公告)号：US20240246974A1
公开(公告)日：2024-07-25
申请号：US18382210
申请日：2023-10-20
发明人： Liangxing Wu , Colin Zhang , Chunhong He , Liang Lu , Wenqing Yao
IPC分类号： C07D471/14 , A61P1/16 , A61P11/00 , A61P19/02 , C07D471/20 , C07D471/22 , C07D491/22 , C07D495/14 , C07D498/14 , C07D498/22
CPC分类号： C07D471/14 , A61P1/16 , A61P11/00 , A61P19/02 , C07D471/20 , C07D471/22 , C07D491/22 , C07D495/14 , C07D498/14 , C07D498/22
摘要： The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US11840534B2
公开(公告)日：2023-12-12
申请号：US17337027
申请日：2021-06-02
发明人： Liangxing Wu , Colin Zhang , Chunhong He , Liang Lu , Wenqing Yao
IPC分类号： C07D471/14 , C07D471/20 , C07D471/22 , C07D491/22 , C07D495/14 , C07D498/14 , C07D498/22 , A61P1/16 , A61P11/00 , A61P19/02
CPC分类号： C07D471/14 , A61P1/16 , A61P11/00 , A61P19/02 , C07D471/20 , C07D471/22 , C07D491/22 , C07D495/14 , C07D498/14 , C07D498/22
摘要： The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US20200377504A1
公开(公告)日：2020-12-03
申请号：US16842558
申请日：2020-04-07
发明人： Liangxing Wu , Colin Zhang , Chunhong He , Yaping Sun , Liang Lu , Ding-Quan Qian , Meizhong Xu , Jincong Zhuo , Wenqing Yao
IPC分类号： C07D471/14 , C07D495/14 , C07D471/20 , C07D498/14 , C07D498/22 , C07D471/22 , C07D491/22 , A61P11/00 , A61P1/16 , A61P19/02
摘要： The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US20170165263A1
公开(公告)日：2017-06-15
申请号：US15359012
申请日：2016-11-22
发明人： Wenqing Yao , Colin Zhang , Meizhong Xu , Jincong Zhuo , Chunhong He
IPC分类号： A61K31/5025 , A61K31/5377
CPC分类号： A61K31/5025 , A61K31/5377 , C07D235/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D487/04
摘要： The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases.
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公开(公告)号：US12084449B2
公开(公告)日：2024-09-10
申请号：US17575371
申请日：2022-01-13
发明人： Jincong Zhuo , Meizhong Xu , Chunhong He , Colin Zhang , Ding-Quan Qian , David M. Burns , Yun-Long Li , Brian Metcalf , Wenqing Yao
IPC分类号： A61P35/00 , A61K31/4709 , A61K31/53 , C07D403/06 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4709 , A61K31/53 , A61P35/00 , C07D403/06
摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
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公开(公告)号：US09371323B2
公开(公告)日：2016-06-21
申请号：US14680745
申请日：2015-04-07
发明人： Wenqing Yao , Jincong Zhuo , Colin Zhang
IPC分类号： C07D471/10
CPC分类号： C07D471/10
摘要： The present invention relates to certain spirocyclic compounds that are inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 (11βHSD1), compositions containing the same, and methods of using the same for the treatment of diabetes, obesity and other diseases.
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公开(公告)号：US20200317680A1
公开(公告)日：2020-10-08
申请号：US16909686
申请日：2020-06-23
发明人： Jincong Zhuo , Meizhong Xu , Chunhong He , Colin Zhang , Ding-Quan Qian , David M. Burns , Yun-Long Li , Brian Metcalf , Wenqing Yao
IPC分类号： C07D487/04 , A61K31/53 , A61K31/4709 , C07D403/06 , A61P35/00
摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
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公开(公告)号：US20180282340A1
公开(公告)日：2018-10-04
申请号：US15925996
申请日：2018-03-20
发明人： Jincong Zhuo , Meizhong Xu , Chunhong He , Colin Zhang , Ding-Quan Qian , David M. Burns , Yun-Long Li , Brian Metcalf , Wenqing Yao
IPC分类号： C07D487/04 , A61K31/53 , A61K31/4709 , C07D403/06
摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
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公开(公告)号：US09957229B2
公开(公告)日：2018-05-01
申请号：US15602693
申请日：2017-05-23
发明人： Wenqing Yao , Jincong Zhuo , Meizhong Xu , Colin Zhang , Brian W. Metcalf , Chunhong He , Ding-Quan Qian
IPC分类号： C07D471/10 , C07D207/06 , A61K31/407 , C07D491/107 , C07D513/10 , C07D498/20 , C07D495/04 , C07D493/10 , C07D491/20 , C07D491/10 , C07D487/10 , C07D487/08 , C07D487/04 , C07D471/04 , C07D417/04 , C07D413/14 , C07D413/10 , C07D405/14 , C07D405/04 , C07D403/04 , C07D401/14 , C07D401/10 , C07D401/06 , C07D401/04 , C07D333/34 , C07D295/185 , C07D221/20 , C07D217/26 , C07D217/06 , C07D213/38 , C07D211/70 , C07D211/66 , C07D211/64 , C07D211/58 , C07D211/52 , C07D211/48 , C07D211/46 , C07D211/34 , C07D211/22 , C07D211/18 , C07D211/16 , C07D209/70 , C07D209/62 , C07D209/52 , C07D209/44 , C07D209/42 , C07D209/08 , C07D207/27 , C07D207/16 , C07D207/14 , C07D207/12 , C07D207/10 , C07D207/08 , A61K31/4439
CPC分类号： C07D207/06 , A61K31/407 , A61K31/4439 , C07D207/08 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/27 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/52 , C07D209/62 , C07D209/70 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/38 , C07D217/06 , C07D217/26 , C07D221/20 , C07D295/185 , C07D333/34 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D491/107 , C07D491/20 , C07D493/10 , C07D495/04 , C07D498/20 , C07D513/10
摘要： The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
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公开(公告)号：US11053246B2
公开(公告)日：2021-07-06
申请号：US16842558
申请日：2020-04-07
发明人： Liangxing Wu , Colin Zhang , Chunhong He , Liang Lu , Wenqing Yao
IPC分类号： C07D471/14 , C07D495/14 , C07D471/20 , C07D498/14 , C07D498/22 , C07D471/22 , C07D491/22 , A61P1/16 , A61P11/00 , A61P19/02
摘要： The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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