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公开(公告)号：US12084449B2
公开(公告)日：2024-09-10
申请号：US17575371
申请日：2022-01-13
发明人： Jincong Zhuo , Meizhong Xu , Chunhong He , Colin Zhang , Ding-Quan Qian , David M. Burns , Yun-Long Li , Brian Metcalf , Wenqing Yao
IPC分类号： A61P35/00 , A61K31/4709 , A61K31/53 , C07D403/06 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4709 , A61K31/53 , A61P35/00 , C07D403/06
摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
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公开(公告)号：US11433071B2
公开(公告)日：2022-09-06
申请号：US16828315
申请日：2020-03-24
发明人： Yun-Long Li , Wenqing Yao , Andrew P. Combs , Eddy W. Yue , Song Mei , Joseph Glenn , Thomas P. Maduskuie, Jr. , Richard B. Sparks , Brent Douty , Chunhong He
IPC分类号： A61K31/519 , C07D471/04 , C07D487/04 , A61P29/00 , C07D519/00
摘要： The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
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![Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors](/abs-image/US/2021/02/16/US10919901B2/abs.jpg.150x150.jpg)
公开(公告)号：US10919901B2
公开(公告)日：2021-02-16
申请号：US16593588
申请日：2019-10-04
发明人： Jincong Zhuo , Chunhong He , Wenqing Yao
IPC分类号： C07D487/04 , C07D403/04 , A61K31/53 , A61P35/00
摘要： The present invention relates to imidazo[1,2-b][1,2,4]triazines that are inhibitors of c-Met and are useful in the treatment of c-Met associated diseases including cancer.
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4.发明申请公开(公告)号：US20200155527A1
公开(公告)日：2020-05-21
申请号：US16685183
申请日：2019-11-15
发明人： Chu-Biao Xue , Yun-Long Li , Hao Feng , Jun Pan , Anlai Wang , Ke Zhang , Wenqing Yao , Fenglei Zhang , Jincong Zhuo
IPC分类号： A61K31/444 , C07D491/048 , C07D471/04 , C07D417/14 , C07D405/14 , C07D401/14 , C07D495/04
摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
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公开(公告)号：US20200095244A1
公开(公告)日：2020-03-26
申请号：US16566509
申请日：2019-09-10
发明人： Yaping Sun , Liang Lu , Wenqing Yao , Jincong Zhuo , Liangxing Wu , Meizhong Xu , Ding-Quan Qian , Chunhong He , Fenglei Zhang
IPC分类号： C07D471/04 , A61P35/00 , A61K31/4375
摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US10513522B2
公开(公告)日：2019-12-24
申请号：US15435735
申请日：2017-02-17
发明人： Wenqing Yao , David M. Burns , Jincong Zhuo
IPC分类号： C07D487/04 , C07D471/04
摘要： The present invention provides azetidinyl phenyl, pyridyl, or pyrazinyl carboxamide derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAKs) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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公开(公告)号：US10226459B2
公开(公告)日：2019-03-12
申请号：US15719949
申请日：2017-09-29
发明人： Wenqing Yao , Jincong Zhuo , Meizhong Xu , Fenglei Zhang , Brian W. Metcalf
IPC分类号： A61K31/496 , A61K31/40 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/4985 , A61K31/55 , A61K31/551 , C07D487/04 , C07D495/04 , C07D221/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , A61K31/495
摘要： The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.
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8.发明申请公开(公告)号：US20190040067A1
公开(公告)日：2019-02-07
申请号：US15910708
申请日：2018-03-02
发明人： Yun-Long Li , Wenqing Yao , Andrew P. Combs , Eddy W. Yue , Song Mei , Wenyu Zhu , Joseph Glenn , Thomas P. Maduskuie, JR. , Richard B. Sparks , Brent Douty , Chunhong He
IPC分类号： C07D487/04 , A61K31/5377 , A61K31/519
摘要： The present application provides methods of treating PI3Kδ related disorders using compounds of Formula I: or pharmaceutically acceptable salts thereof.
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公开(公告)号：US10092570B2
公开(公告)日：2018-10-09
申请号：US15673529
申请日：2017-08-10
发明人： Yun-Long Li , Wenqing Yao , Andrew P. Combs , Eddy W. Yue , Song Mei , Wenyu Zhu , Joseph Glenn , Thomas P. Maduskuie, Jr. , Richard B. Sparks , Brent Douty , Chunhong He
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , C07D519/00
摘要： The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
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10.发明申请公开(公告)号：US20180193323A1
公开(公告)日：2018-07-12
申请号：US15815255
申请日：2017-11-16
发明人： Chu-Biao Xue , Yun-Long Li , Hao Feng , Jun Pan , Anlai Wang , Ke Zhang , Wenqing Yao , Fenglei Zhang , Jincong Zhuo
IPC分类号： A61K31/444 , C07D495/04 , C07D491/048 , C07D401/14 , C07D417/14 , C07D405/14 , C07D471/04
CPC分类号： A61K31/444 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
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