-
公开(公告)号：US12084449B2
公开(公告)日：2024-09-10
申请号：US17575371
申请日：2022-01-13
发明人： Jincong Zhuo , Meizhong Xu , Chunhong He , Colin Zhang , Ding-Quan Qian , David M. Burns , Yun-Long Li , Brian Metcalf , Wenqing Yao
IPC分类号： A61P35/00 , A61K31/4709 , A61K31/53 , C07D403/06 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4709 , A61K31/53 , A61P35/00 , C07D403/06
摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
-
![Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors](/abs-image/US/2021/02/16/US10919901B2/abs.jpg.150x150.jpg)
公开(公告)号：US10919901B2
公开(公告)日：2021-02-16
申请号：US16593588
申请日：2019-10-04
发明人： Jincong Zhuo , Chunhong He , Wenqing Yao
IPC分类号： C07D487/04 , C07D403/04 , A61K31/53 , A61P35/00
摘要： The present invention relates to imidazo[1,2-b][1,2,4]triazines that are inhibitors of c-Met and are useful in the treatment of c-Met associated diseases including cancer.
-
3.发明申请公开(公告)号：US20200155527A1
公开(公告)日：2020-05-21
申请号：US16685183
申请日：2019-11-15
发明人： Chu-Biao Xue , Yun-Long Li , Hao Feng , Jun Pan , Anlai Wang , Ke Zhang , Wenqing Yao , Fenglei Zhang , Jincong Zhuo
IPC分类号： A61K31/444 , C07D491/048 , C07D471/04 , C07D417/14 , C07D405/14 , C07D401/14 , C07D495/04
摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
-
公开(公告)号：US20200095244A1
公开(公告)日：2020-03-26
申请号：US16566509
申请日：2019-09-10
发明人： Yaping Sun , Liang Lu , Wenqing Yao , Jincong Zhuo , Liangxing Wu , Meizhong Xu , Ding-Quan Qian , Chunhong He , Fenglei Zhang
IPC分类号： C07D471/04 , A61P35/00 , A61K31/4375
摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
-
公开(公告)号：US10513522B2
公开(公告)日：2019-12-24
申请号：US15435735
申请日：2017-02-17
发明人： Wenqing Yao , David M. Burns , Jincong Zhuo
IPC分类号： C07D487/04 , C07D471/04
摘要： The present invention provides azetidinyl phenyl, pyridyl, or pyrazinyl carboxamide derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAKs) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
-
公开(公告)号：US10226459B2
公开(公告)日：2019-03-12
申请号：US15719949
申请日：2017-09-29
发明人： Wenqing Yao , Jincong Zhuo , Meizhong Xu , Fenglei Zhang , Brian W. Metcalf
IPC分类号： A61K31/496 , A61K31/40 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/4985 , A61K31/55 , A61K31/551 , C07D487/04 , C07D495/04 , C07D221/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , A61K31/495
摘要： The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.
-
7.发明申请公开(公告)号：US20180193323A1
公开(公告)日：2018-07-12
申请号：US15815255
申请日：2017-11-16
发明人： Chu-Biao Xue , Yun-Long Li , Hao Feng , Jun Pan , Anlai Wang , Ke Zhang , Wenqing Yao , Fenglei Zhang , Jincong Zhuo
IPC分类号： A61K31/444 , C07D495/04 , C07D491/048 , C07D401/14 , C07D417/14 , C07D405/14 , C07D471/04
CPC分类号： A61K31/444 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
-
公开(公告)号：US09371323B2
公开(公告)日：2016-06-21
申请号：US14680745
申请日：2015-04-07
发明人： Wenqing Yao , Jincong Zhuo , Colin Zhang
IPC分类号： C07D471/10
CPC分类号： C07D471/10
摘要： The present invention relates to certain spirocyclic compounds that are inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 (11βHSD1), compositions containing the same, and methods of using the same for the treatment of diabetes, obesity and other diseases.
-
9.发明申请THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS 有权作为PIM激酶抑制剂有用的噻唑并恶唑和吡啶甲酰胺化合物公开(公告)号：US20150329534A1
公开(公告)日：2015-11-19
申请号：US14811038
申请日：2015-07-28
发明人： Chu-Biao Xue , Yun-Long Li , Hao Feng , Jun Pan , Anlai Wang , Ke Zhang , Wenqing Yao , Fenglei Zhang , Jincong Zhuo
IPC分类号： C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
CPC分类号： A61K31/444 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
摘要翻译： 本公开描述了噻唑和吡啶甲酰胺衍生物，其组合物和使用方法。 所述化合物抑制Pim激酶的活性，并且可用于治疗与Pim激酶的活性相关的疾病，包括例如癌症和其它疾病。
-
公开(公告)号：US11229631B2
公开(公告)日：2022-01-25
申请号：US17022803
申请日：2020-09-16
发明人： Chu-Biao Xue , Yun-Long Li , Hao Feng , Jun Pan , Anlai Wang , Ke Zhang , Wenqing Yao , Fenglei Zhang , Jincong Zhuo
IPC分类号： A61K31/444 , C07D495/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D491/048
摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
-
-
-
-
-
-
-
-
-
搜索结果
97 条记录 (耗时 0.054 秒)
