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公开(公告)号：US12084449B2
公开(公告)日：2024-09-10
申请号：US17575371
申请日：2022-01-13
发明人： Jincong Zhuo , Meizhong Xu , Chunhong He , Colin Zhang , Ding-Quan Qian , David M. Burns , Yun-Long Li , Brian Metcalf , Wenqing Yao
IPC分类号： A61P35/00 , A61K31/4709 , A61K31/53 , C07D403/06 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4709 , A61K31/53 , A61P35/00 , C07D403/06
摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
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公开(公告)号：US20200095244A1
公开(公告)日：2020-03-26
申请号：US16566509
申请日：2019-09-10
发明人： Yaping Sun , Liang Lu , Wenqing Yao , Jincong Zhuo , Liangxing Wu , Meizhong Xu , Ding-Quan Qian , Chunhong He , Fenglei Zhang
IPC分类号： C07D471/04 , A61P35/00 , A61K31/4375
摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US10226459B2
公开(公告)日：2019-03-12
申请号：US15719949
申请日：2017-09-29
发明人： Wenqing Yao , Jincong Zhuo , Meizhong Xu , Fenglei Zhang , Brian W. Metcalf
IPC分类号： A61K31/496 , A61K31/40 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/4985 , A61K31/55 , A61K31/551 , C07D487/04 , C07D495/04 , C07D221/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , A61K31/495
摘要： The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.
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公开(公告)号：US20200377504A1
公开(公告)日：2020-12-03
申请号：US16842558
申请日：2020-04-07
发明人： Liangxing Wu , Colin Zhang , Chunhong He , Yaping Sun , Liang Lu , Ding-Quan Qian , Meizhong Xu , Jincong Zhuo , Wenqing Yao
IPC分类号： C07D471/14 , C07D495/14 , C07D471/20 , C07D498/14 , C07D498/22 , C07D471/22 , C07D491/22 , A61P11/00 , A61P1/16 , A61P19/02
摘要： The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US20180153882A1
公开(公告)日：2018-06-07
申请号：US15719949
申请日：2017-09-29
发明人： Wenqing Yao , Jincong Zhuo , Meizhong Xu , Fenglei Zhang , Brian W. Metcalf
IPC分类号： A61K31/496 , A61K31/40 , C07D487/04 , C07D495/04 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/4985 , A61K31/55 , A61K31/551 , C07D221/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04
CPC分类号： A61K31/496 , A61K31/40 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/4985 , A61K31/55 , A61K31/551 , C07D221/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.
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公开(公告)号：US20170165263A1
公开(公告)日：2017-06-15
申请号：US15359012
申请日：2016-11-22
发明人： Wenqing Yao , Colin Zhang , Meizhong Xu , Jincong Zhuo , Chunhong He
IPC分类号： A61K31/5025 , A61K31/5377
CPC分类号： A61K31/5025 , A61K31/5377 , C07D235/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D487/04
摘要： The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases.
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公开(公告)号：US09266892B2
公开(公告)日：2016-02-23
申请号：US14132653
申请日：2013-12-18
发明人： Jincong Zhuo , Meizhong Xu , Ding-Quan Qian
IPC分类号： A61K31/498 , C07D487/04 , C07D471/04 , A61K31/519 , A61K31/5025 , A61K31/437
CPC分类号： C07D487/04 , A61K31/437 , A61K31/498 , A61K31/5025 , A61K31/519 , C07D471/04
摘要： The present invention relates to fused pyrazole derivatives, and pharmaceutical compositions including the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
摘要翻译： 本发明涉及稠合的吡唑衍生物和包含它们的药物组合物，其是一种或多种FGFR酶的抑制剂，并且可用于治疗FGFR相关疾病如癌症。
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公开(公告)号：US20210395246A1
公开(公告)日：2021-12-23
申请号：US17160628
申请日：2021-01-28
发明人： Yaping Sun , Liang Lu , Wenqing Yao , Jincong Zhuo , Liangxing Wu , Meizhong Xu , Ding-Quan Qian , Chunhong He , Fenglei Zhang
IPC分类号： C07D471/04 , A61P35/00 , A61K31/4375
摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US20190240220A1
公开(公告)日：2019-08-08
申请号：US16238277
申请日：2019-01-02
发明人： Wenqing Yao , Colin Zhang , Meizhong Xu , Jincong Zhuo , Chunhong He
IPC分类号： A61K31/5025 , C07D403/04 , C07D487/04 , C07D407/12 , C07D405/14 , C07D235/06 , C07D403/12 , C07D401/14 , C07D401/12 , A61K31/5377 , C07D405/12
摘要： The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases.
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公开(公告)号：US10213427B2
公开(公告)日：2019-02-26
申请号：US15359012
申请日：2016-11-22
发明人： Wenqing Yao , Colin Zhang , Meizhong Xu , Jincong Zhuo , Chunhong He
IPC分类号： C07D235/06 , A61K31/5025 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D487/04 , C07D403/04 , A61K31/5377
摘要： The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases.
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