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公开(公告)号：US12084449B2
公开(公告)日：2024-09-10
申请号：US17575371
申请日：2022-01-13
发明人： Jincong Zhuo , Meizhong Xu , Chunhong He , Colin Zhang , Ding-Quan Qian , David M. Burns , Yun-Long Li , Brian Metcalf , Wenqing Yao
IPC分类号： A61P35/00 , A61K31/4709 , A61K31/53 , C07D403/06 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4709 , A61K31/53 , A61P35/00 , C07D403/06
摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
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公开(公告)号：US11433071B2
公开(公告)日：2022-09-06
申请号：US16828315
申请日：2020-03-24
发明人： Yun-Long Li , Wenqing Yao , Andrew P. Combs , Eddy W. Yue , Song Mei , Joseph Glenn , Thomas P. Maduskuie, Jr. , Richard B. Sparks , Brent Douty , Chunhong He
IPC分类号： A61K31/519 , C07D471/04 , C07D487/04 , A61P29/00 , C07D519/00
摘要： The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
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![Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors](/abs-image/US/2021/02/16/US10919901B2/abs.jpg.150x150.jpg)
公开(公告)号：US10919901B2
公开(公告)日：2021-02-16
申请号：US16593588
申请日：2019-10-04
发明人： Jincong Zhuo , Chunhong He , Wenqing Yao
IPC分类号： C07D487/04 , C07D403/04 , A61K31/53 , A61P35/00
摘要： The present invention relates to imidazo[1,2-b][1,2,4]triazines that are inhibitors of c-Met and are useful in the treatment of c-Met associated diseases including cancer.
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公开(公告)号：US20200095244A1
公开(公告)日：2020-03-26
申请号：US16566509
申请日：2019-09-10
发明人： Yaping Sun , Liang Lu , Wenqing Yao , Jincong Zhuo , Liangxing Wu , Meizhong Xu , Ding-Quan Qian , Chunhong He , Fenglei Zhang
IPC分类号： C07D471/04 , A61P35/00 , A61K31/4375
摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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5.发明申请公开(公告)号：US20190040067A1
公开(公告)日：2019-02-07
申请号：US15910708
申请日：2018-03-02
发明人： Yun-Long Li , Wenqing Yao , Andrew P. Combs , Eddy W. Yue , Song Mei , Wenyu Zhu , Joseph Glenn , Thomas P. Maduskuie, JR. , Richard B. Sparks , Brent Douty , Chunhong He
IPC分类号： C07D487/04 , A61K31/5377 , A61K31/519
摘要： The present application provides methods of treating PI3Kδ related disorders using compounds of Formula I: or pharmaceutically acceptable salts thereof.
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公开(公告)号：US10092570B2
公开(公告)日：2018-10-09
申请号：US15673529
申请日：2017-08-10
发明人： Yun-Long Li , Wenqing Yao , Andrew P. Combs , Eddy W. Yue , Song Mei , Wenyu Zhu , Joseph Glenn , Thomas P. Maduskuie, Jr. , Richard B. Sparks , Brent Douty , Chunhong He
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , C07D519/00
摘要： The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
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![Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors](/abs-image/US/2017/08/29/US09745311B2/abs.jpg.150x150.jpg)
公开(公告)号：US09745311B2
公开(公告)日：2017-08-29
申请号：US15181903
申请日：2016-06-14
发明人： Liang Lu , Chunhong He , Wenqing Yao
IPC分类号： C07D487/04 , C07D495/04 , C07D519/00
CPC分类号： C07D487/04 , C07D495/04 , C07D519/00
摘要： The present invention relates to pyrazine derivatives of Formula I, and pharmaceutical compositions including the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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![Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors](/abs-image/US/2016/07/12/US09388185B2/abs.jpg.150x150.jpg)
公开(公告)号：US09388185B2
公开(公告)日：2016-07-12
申请号：US13963569
申请日：2013-08-09
发明人： Liang Lu , Chunhong He , Wenqing Yao
IPC分类号： A61K31/4985 , C07D241/38 , C07D487/04 , C07D495/04
CPC分类号： C07D487/04 , C07D495/04 , C07D519/00
摘要： The present invention relates to pyrazine derivatives of Formula I, and pharmaceutical compositions including the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
摘要翻译： 本发明涉及式I的吡嗪衍生物和包含其的药物组合物，其是一种或多种FGFR酶的抑制剂，并且可用于治疗FGFR相关疾病如癌症。
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公开(公告)号：US11530214B2
公开(公告)日：2022-12-20
申请号：US17160628
申请日：2021-01-28
发明人： Liang Lu , Wenqing Yao , Chunhong He , Fenglei Zhang
IPC分类号： A61P35/00 , A61K31/4375 , C07D471/04
摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US20200323858A1
公开(公告)日：2020-10-15
申请号：US16828315
申请日：2020-03-24
发明人： Yun-Long Li , Wenqing Yao , Andrew P. Combs , Eddy W. Yue , Song Mei , Joseph Glenn , Thomas P. Maduskuie, Jr. , Richard B. Sparks , Brent Douty , Chunhong He
IPC分类号： A61K31/519 , A61P29/00 , C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
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