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    Portable genetic detection and analysis system and method
    3.
    发明授权
    Portable genetic detection and analysis system and method 有权

    公开(公告)号：US11634746B2

    公开(公告)日：2023-04-25

    申请号：US16540769

    申请日：2019-08-14

    Applicant: Illumina, Inc.

    Inventor： Robert C. Kain ,  Min-Jui Richard Shen ,  John A. Moon ,  Helmy A. Eltoukhy

    IPC: C12Q1/68 ,  C12Q1/6837 ,  C12Q1/6869 ,  G01N33/487 ,  B01L3/00 ,  G01N35/00

    Abstract: A portable detector is disclosed for detecting certain analytes of interest, such as genetic material (e.g., nucleic acids). The detector includes a reading component for the detection of the analytes, and control circuitry for controlling operation of the reading component. Processing circuitry may be included to perform both primary analysis of acquired data, and where desired, secondary analysis. Where desired, some or all of the computationally intensive tasks may be off-loaded to enhance the portability and speed of the device. The device may incorporate various types of interface, technologies for reading and analysis, positioning system interfaces, and so forth. A number of exemplary use cases and methods are also disclosed.

    Sequencing by orthogonal synthesis
    6.
    发明授权
    Sequencing by orthogonal synthesis 有权
    通过正交合成测序

    公开(公告)号：US09193999B2

    公开(公告)日：2015-11-24

    申请号：US14314864

    申请日：2014-06-25

    Applicant: ILLUMINA, INC.

    Inventor： Martin Maria Fabani ,  Maria Candelaria Rogert Bacigalupo ,  John A. Moon

    IPC: C12Q1/68

    CPC classification number: C12Q1/6869 ,  C07H21/02 ,  C07H21/04 ,  C12N9/00 ,  C12P19/30 ,  C12Q1/6874 ,  C12Q2521/101 ,  C12Q2521/119 ,  C12Q2525/101 ,  C12Q2533/101 ,  C12Q2533/107 ,  C12Q2535/122 ,  C12Q2565/507 ,  C12Q2565/518 ,  C12Q2565/537

    Abstract: A method for sequencing includes steps of (a) providing first and second nucleic acid templates, wherein the two templates have different sequences; (b) extending a first primer bound to the first template using a first polymerase species and a first set of nucleotide analogs; (c) extending a second primer bound to the second template using a second polymerase species and a second set of nucleotide analogs, wherein the first polymerase species is different from the second polymerase species and wherein the first set of nucleotide analog is different from the second set of nucleotide analog, (d) detecting the first and second primer extension products; and (e) repeating steps (b) through (d), thereby determining the different sequences of the first and second templates.

    Abstract translation: 一种用于测序的方法包括以下步骤：（a）提供第一和第二核酸模板，其中两个模板具有不同的序列; （b）使用第一聚合酶种类和第一组核苷酸类似物扩展与第一模板结合的第一引物; （c）使用第二聚合酶种类和第二组核苷酸类似物扩展与第二模板结合的第二引物，其中第一聚合酶种类与第二聚合酶种类不同，并且其中第一组核苷酸类似物不同于第二种 一套核苷酸类似物，（d）检测第一和第二引物延伸产物; 和（e）重复步骤（b）至（d），从而确定第一和第二模板的不同序列。

    Patterned flow-cells useful for nucleic acid analysis
    8.
    发明授权
    Patterned flow-cells useful for nucleic acid analysis 有权

    公开(公告)号：US12163180B2

    公开(公告)日：2024-12-10

    申请号：US17010675

    申请日：2020-09-02

    Applicant: ILLUMINA, INC.

    Inventor： Shengrong Lin ,  Yir-Shyuan Wu ,  Kevin Gunderson ,  John A. Moon

    IPC: C12Q1/6806 ,  C12Q1/6837 ,  G01N27/447

    Abstract: Provided is a surface having metal regions and an interstitial region having a composition that differs from the metal regions, wherein a continuous gel layer coats the surface across the metal regions and the interstitial regions. Nucleic acids or other analytes can be attached to the continuous gel layer such that a greater amount is attached over the metal regions than over the interstitial region. Also provided are methods for making such surfaces. Methods are also provided for making an array of nucleic acids or other analytes using such surfaces.

    Patterned flow-cells useful for nucleic acid analysis
    9.
    发明授权
    Patterned flow-cells useful for nucleic acid analysis 有权

    公开(公告)号：US10787698B2

    公开(公告)日：2020-09-29

    申请号：US14304556

    申请日：2014-06-13

    Applicant: ILLUMINA, INC.

    Inventor： Shengrong Lin ,  Yir-Shyuan Wu ,  Kevin Gunderson ,  John A. Moon

    IPC: C12Q1/6806 ,  C12Q1/6837 ,  G01N27/447

    Abstract: Provided is a surface having metal regions and an interstitial region having a composition that differs from the metal regions, wherein a continuous gel layer coats the surface across the metal regions and the interstitial regions. Nucleic acids or other analytes can be attached to the continuous gel layer such that a greater amount is attached over the metal regions than over the interstitial region. Also provided are methods for making such surfaces. Methods are also provided for making an array of nucleic acids or other analytes using such surfaces.

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