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    SYSTEMS, METHODS, AND APPARATUSES TO IMAGE A SAMPLE FOR BIOLOGICAL OR CHEMICAL ANALYSIS
    2.
    发明申请
    SYSTEMS, METHODS, AND APPARATUSES TO IMAGE A SAMPLE FOR BIOLOGICAL OR CHEMICAL ANALYSIS 有权

    公开(公告)号：US20220226819A1

    公开(公告)日：2022-07-21

    申请号：US17714129

    申请日：2022-04-05

    Applicant: ILLUMINA, INC.

    Inventor： Erik Williamson ,  Bryan Crane ,  Patrick Leung ,  Drew Verkade ,  Mark Reed

    IPC: B01L3/00 ,  B01L9/00 ,  G01N21/05

    Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.

    SYSTEMS, METHODS, AND APPARATUSES TO IMAGE A SAMPLE FOR BIOLOGICAL OR CHEMICAL ANALYSIS
    6.
    发明申请
    SYSTEMS, METHODS, AND APPARATUSES TO IMAGE A SAMPLE FOR BIOLOGICAL OR CHEMICAL ANALYSIS 审中-公开

    公开(公告)号：US20190151845A1

    公开(公告)日：2019-05-23

    申请号：US16255546

    申请日：2019-01-23

    Applicant: Illumina, Inc.

    Inventor： Erik Williamson ,  Bryan Crane ,  Patrick Leung ,  Drew Verkade ,  Mark T. Reed

    IPC: B01L3/00 ,  G01N21/05 ,  B01L9/00

    Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.

    SYSTEM OR DEVICE FOR BIOCHEMICAL ANALYSIS HAVING AT LEAST ONE ELECTROOSMOTIC PUMP
    7.
    发明申请
    SYSTEM OR DEVICE FOR BIOCHEMICAL ANALYSIS HAVING AT LEAST ONE ELECTROOSMOTIC PUMP 有权
    用于生物化学分析的系统或装置，具有至少一个电动泵

    公开(公告)号：US20140080205A1

    公开(公告)日：2014-03-20

    申请号：US14085122

    申请日：2013-11-20

    Applicant: THE ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY ,  ILLUMINA, INC.

    Inventor： Jonathan Posner ,  Kamil Salloum ,  Michal Lebl ,  Mark Reed ,  Dale Buermann ,  Matthew Hage ,  Bryan Crane ,  David Heiner ,  Robert Kain ,  Michael Schroeder

    IPC: F04B37/10

    CPC classification number: F04B37/10 ,  F04B19/00 ,  Y10T436/2575

    Abstract: An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.

    Abstract translation: 提供一种电渗（EO）泵，其包括具有泵腔的壳体，多孔芯介质和电极。 多孔芯介质定位在泵腔内以形成至少部分地围绕多孔芯介质的外表面延伸的外部储存器。 多孔芯介质具有设置在其中的开放内室。 内室表示内部储存器。 电极定位在内室中并且位于外表面附近。 电极通过多孔芯介质在内部和外部储存器之间引导流体流动，其中当电极引起流体流动时产生气体。 壳体具有用于将流体输送到内部储存器和外部储存器中的一个的流体入口。 壳体具有流体出口，以从另一个内部储存器和外部储存器排出流体。 壳体具有用于从泵腔去除气体的气体去除装置。

    SYSTEMS, METHODS, AND APPARATUSES TO IMAGE A SAMPLE FOR BIOLOGICAL OR CHEMICAL ANALYSIS
    8.
    发明申请
    SYSTEMS, METHODS, AND APPARATUSES TO IMAGE A SAMPLE FOR BIOLOGICAL OR CHEMICAL ANALYSIS 有权

    公开(公告)号：US20250033046A1

    公开(公告)日：2025-01-30

    申请号：US18917940

    申请日：2024-10-16

    Applicant: ILLUMINA, INC.

    Inventor： Erik Williamson ,  Bryan Crane ,  Patrick Leung ,  Drew Verkade ,  Mark T. Reed

    IPC: B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01N21/05

    Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.

    SUBSTRATES FOR PERFORMING QUANTIFICATION PROCESSES AND RELATED SYSTEMS AND METHODS
    9.
    发明公开
    SUBSTRATES FOR PERFORMING QUANTIFICATION PROCESSES AND RELATED SYSTEMS AND METHODS 审中-公开

    公开(公告)号：US20230418039A1

    公开(公告)日：2023-12-28

    申请号：US18214907

    申请日：2023-06-27

    Applicant: ILLUMINA, INC.

    Inventor： Bryan Crane

    IPC: G02B21/24

    CPC classification number: G02B21/244

    Abstract: Substrates for performing quantification processes and related systems and methods are disclosed. In an implementation, an apparatus includes a substrate and an imaging system. The substrate includes a pair of plates and a plurality of spacers positioned between the plates to define a gap between the pair of plates. A portion of a sample is to be received within the gap of the substrate and the imaging system is to obtain image data of the portion of the sample. The image data is to be used to determine a concentration of the portion of the sample.

    INTEGRATED OPTOELECTRONIC READ HEAD AND FLUIDIC CARTRIDGE USEFUL FOR NUCLEIC ACID SEQUENCING
    10.
    发明申请
    INTEGRATED OPTOELECTRONIC READ HEAD AND FLUIDIC CARTRIDGE USEFUL FOR NUCLEIC ACID SEQUENCING 有权
    用于核酸序列的集成光电阅读头和流体盒

    公开(公告)号：US20140329694A1

    公开(公告)日：2014-11-06

    申请号：US14335117

    申请日：2014-07-18

    Applicant: ILLUMINA, INC.

    Inventor： Dale Buermann ,  John A. Moon ,  Bryan Crane ,  Mark Wang ,  Stanley S. Hong ,  Jason Harris ,  Matthew Hage ,  Mark J. Nibbe

    IPC: C12Q1/68

    CPC classification number: B01L3/527 ,  B01L3/502715 ,  B01L2200/16 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/06 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/6428 ,  G01N21/6486 ,  G01N2021/0307 ,  G01N2021/0325 ,  G01N2021/058 ,  G01N2021/6417 ,  G01N2021/6441 ,  G01N2021/6482

    Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.

    Abstract translation: 一种检测装置，具有包括多个微量荧光计的读取头，所述多个微量荧光计定位成在公共平面中同时获取多个所述宽视场图像; 和（b）平移台，其配置成沿着位于公共平面中的基板移动读取头。 基底可以是包含在药筒中的流动池，药筒还包括用于（i）样品储存器的壳体; （ii）样品储存器和流动池之间的流体管线; （iii）与所述流动池流体连通的若干试剂储存器，（iv）至少一个构造成介导所述储存器与所述流动池之间的流体连通的阀; 和（v）至少一个压力源，其构造成将液体从储存器移动到流动池。 检测装置和盒可以一起使用或彼此独立使用。

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