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公开(公告)号:US20250033046A1
公开(公告)日:2025-01-30
申请号:US18917940
申请日:2024-10-16
Applicant: ILLUMINA, INC.
Inventor: Erik Williamson , Bryan Crane , Patrick Leung , Drew Verkade , Mark T. Reed
Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.
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公开(公告)号:USRE48993E1
公开(公告)日:2022-03-29
申请号:US16550044
申请日:2019-08-23
Applicant: Illumina, Inc.
Inventor: Michael Stone , Drew Verkade
Abstract: A fluidic system that includes a reagent manifold comprising a plurality of channels configured for fluid communication between a reagent cartridge and an inlet of a flow cell; a plurality of reagent sippers extending downward from ports in the manifold, each of the reagent sippers configured to be placed into a reagent reservoir in a reagent cartridge so that liquid reagent can be drawn from the reagent reservoir into the sipper; at least one valve configured to mediate fluid communication between the reservoirs and the inlet of the flow cell. The reagent manifold can also include cache reservoirs for reagent re-use.
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公开(公告)号:US20220226819A1
公开(公告)日:2022-07-21
申请号:US17714129
申请日:2022-04-05
Applicant: ILLUMINA, INC.
Inventor: Erik Williamson , Bryan Crane , Patrick Leung , Drew Verkade , Mark Reed
Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.
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公开(公告)号:US11938479B2
公开(公告)日:2024-03-26
申请号:US18144485
申请日:2023-05-08
Applicant: ILLUMINA, INC.
Inventor: Erik Williamson , Bryan Crane , Patrick Leung , Drew Verkade , Mark T. Reed
CPC classification number: B01L3/502715 , B01L9/527 , G01N21/05 , B01L3/50273 , B01L7/52 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0689 , B01L2300/022 , B01L2300/041 , B01L2300/043 , B01L2300/0816 , B01L2300/0877 , G01N2021/058 , Y10T436/25
Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.
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公开(公告)号:US10220386B2
公开(公告)日:2019-03-05
申请号:US14550956
申请日:2014-11-22
Applicant: ILLUMINA, INC.
Inventor: Erik Williamson , Bryan Crane , Patrick Leung , Drew Verkade , Mark T. Reed
Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.
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6.
公开(公告)号:US20230311119A1
公开(公告)日:2023-10-05
申请号:US18144485
申请日:2023-05-08
Applicant: ILLUMINA, INC.
Inventor: Erik Williamson , Bryan Crane , Patrick Leung , Drew Verkade , Mark T. Reed
CPC classification number: B01L3/502715 , B01L9/527 , G01N21/05 , B01L7/52 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2300/043 , B01L2300/0816 , B01L2300/0877 , Y10T436/25
Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.
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7.
公开(公告)号:US20190151845A1
公开(公告)日:2019-05-23
申请号:US16255546
申请日:2019-01-23
Applicant: Illumina, Inc.
Inventor: Erik Williamson , Bryan Crane , Patrick Leung , Drew Verkade , Mark T. Reed
Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.
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公开(公告)号:US20160319350A1
公开(公告)日:2016-11-03
申请号:US15204717
申请日:2016-07-07
Applicant: Illumina, Inc.
Inventor: Michael Stone , Drew Verkade
CPC classification number: C12Q1/6874 , B01L3/021 , B01L3/0268 , B01L3/0275 , B01L3/502715 , B01L3/502738 , B01L3/527 , B01L2200/025 , B01L2200/026 , B01L2200/0621 , B01L2200/16 , B01L2300/0654 , B01L2300/0867 , B01L2300/0877 , B01L2300/0883 , B01L2300/0887 , B01L2300/168 , B01L2400/02 , B01L2400/0622 , B01L2400/086 , G01N21/6428 , G01N21/6456 , G01N35/1002 , G01N35/1016 , G01N35/1065 , G01N35/1097 , G01N2035/00237 , Y10T436/2575
Abstract: A fluidic system that includes a reagent manifold comprising a plurality of channels configured for fluid communication between a reagent cartridge and an inlet of a flow cell; a plurality of reagent sippers extending downward from ports in the manifold, each of the reagent sippers configured to be placed into a reagent reservoir in a reagent cartridge so that liquid reagent can be drawn from the reagent reservoir into the sipper; at least one valve configured to mediate fluid communication between the reservoirs and the inlet of the flow cell. The reagent manifold can also include cache reservoirs for reagent re-use.
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公开(公告)号:US09410977B2
公开(公告)日:2016-08-09
申请号:US14453868
申请日:2014-08-07
Applicant: Illumina, Inc.
Inventor: Michael Stone , Drew Verkade
CPC classification number: C12Q1/6874 , B01L3/021 , B01L3/0268 , B01L3/0275 , B01L3/502715 , B01L3/502738 , B01L3/527 , B01L2200/025 , B01L2200/026 , B01L2200/0621 , B01L2200/16 , B01L2300/0654 , B01L2300/0867 , B01L2300/0877 , B01L2300/0883 , B01L2300/0887 , B01L2300/168 , B01L2400/02 , B01L2400/0622 , B01L2400/086 , G01N21/6428 , G01N21/6456 , G01N35/1002 , G01N35/1016 , G01N35/1065 , G01N35/1097 , G01N2035/00237 , Y10T436/2575
Abstract: A fluidic system that includes a reagent manifold comprising a plurality of channels configured for fluid communication between a reagent cartridge and an inlet of a flow cell; a plurality of reagent sippers extending downward from ports in the manifold, each of the reagent sippers configured to be placed into a reagent reservoir in a reagent cartridge so that liquid reagent can be drawn from the reagent reservoir into the sipper; at least one valve configured to mediate fluid communication between the reservoirs and the inlet of the flow cell. The reagent manifold can also include cache reservoirs for reagent re-use.
Abstract translation: 一种流体系统,其包括试剂歧管,所述试剂歧管包括被配置用于在试剂盒和流动池的入口之间流体连通的多个通道; 多个试剂槽,其从歧管的端口向下延伸,每个试剂托架被配置成放置在试剂盒中的试剂容器中,使得液体试剂可以从试剂储存器抽入吸嘴; 至少一个阀构造成调节储存器与流动池的入口之间的流体连通。 试剂歧管还可以包括用于试剂重新使用的缓存储存器。
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公开(公告)号:US12151241B2
公开(公告)日:2024-11-26
申请号:US18586010
申请日:2024-02-23
Applicant: ILLUMINA, INC.
Inventor: Erik Williamson , Bryan Crane , Patrick Leung , Drew Verkade , Mark T. Reed
Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.
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