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1.发明授权公开(公告)号：US11565267B2
公开(公告)日：2023-01-31
申请号：US16735001
申请日：2020-01-06
Applicant: Illumina, Inc.
Inventor： Dale Buermann , John A. Moon , Bryan Crane , Mark Wang , Stanley S. Hong , Jason Harris , Matthew Hage , Mark J. Nibbe
IPC: B01L3/00 , G01N21/05 , C12Q1/6869 , G01N21/64 , C12Q1/6874 , G01N21/03
Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.
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2.发明授权公开(公告)号：US10549281B2
公开(公告)日：2020-02-04
申请号：US15594413
申请日：2017-05-12
Applicant: Illumina, Inc.
Inventor： Dale Buermann , John A. Moon , Bryan Crane , Mark Wang , Stanley S. Hong , Jason Harris , Matthew Hage , Mark J. Nibbe
IPC: B01L3/00 , C12Q1/6869 , G01N21/64 , C12Q1/6874 , G01N21/03 , G01N21/05
Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.
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公开(公告)号：US10301670B2
公开(公告)日：2019-05-28
申请号：US15425747
申请日：2017-02-06
Applicant: Illumina, Inc.
Inventor： Jason Harris , Stephen Tanner
IPC: C12Q1/68 , C12Q1/6837 , B01J19/00
Abstract: The present techniques provides methods for use in conjunction with an article of manufacture having a plurality of sample sites of an array and to identify sample sites based on image data. The array may be divided into a series of domains with each domain having patterns of sample sites. Neighboring domains may be oriented at different angles such that each domain does not have the same pattern orientation.
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4.发明申请公开(公告)号：US20230137970A1
公开(公告)日：2023-05-04
申请号：US18091116
申请日：2022-12-29
Applicant: ILLUMINA, INC.
Inventor： Dale Buermann , John A. Moon , Bryan Crane , Mark Wang , Stanley S. Hong , Jason Harris , Matthew Hage , Mark J. Nibbe
IPC: B01L3/00 , C12Q1/6869 , G01N21/64 , C12Q1/6874
Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir, (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.
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公开(公告)号：US20170145488A1
公开(公告)日：2017-05-25
申请号：US15425747
申请日：2017-02-06
Applicant: Illumina, Inc.
Inventor： Jason Harris , Stephen Tanner
IPC: C12Q1/68
CPC classification number: C12Q1/6837 , B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00662 , B01J2219/00693 , B01J2219/00722
Abstract: An article of manufacture having a plurality of sites in domains of regular patterns. Neighboring domains are oriented at different angles to improve the identification of the sites.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20140329694A1
公开(公告)日：2014-11-06
申请号：US14335117
申请日：2014-07-18
Applicant: ILLUMINA, INC.
Inventor： Dale Buermann , John A. Moon , Bryan Crane , Mark Wang , Stanley S. Hong , Jason Harris , Matthew Hage , Mark J. Nibbe
IPC: C12Q1/68
CPC classification number: B01L3/527 , B01L3/502715 , B01L2200/16 , B01L2300/0877 , B01L2400/0487 , B01L2400/06 , C12Q1/6869 , C12Q1/6874 , G01N21/6428 , G01N21/6486 , G01N2021/0307 , G01N2021/0325 , G01N2021/058 , G01N2021/6417 , G01N2021/6441 , G01N2021/6482
Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.
Abstract translation: 一种检测装置，具有包括多个微量荧光计的读取头，所述多个微量荧光计定位成在公共平面中同时获取多个所述宽视场图像; 和（b）平移台，其配置成沿着位于公共平面中的基板移动读取头。 基底可以是包含在药筒中的流动池，药筒还包括用于（i）样品储存器的壳体; （ii）样品储存器和流动池之间的流体管线; （iii）与所述流动池流体连通的若干试剂储存器，（iv）至少一个构造成介导所述储存器与所述流动池之间的流体连通的阀; 和（v）至少一个压力源，其构造成将液体从储存器移动到流动池。 检测装置和盒可以一起使用或彼此独立使用。
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7.发明申请公开(公告)号：US20130260372A1
公开(公告)日：2013-10-03
申请号：US13766413
申请日：2013-02-13
Applicant: ILLUMINA, INC.
Inventor： Dale Buermann , John A. Moon , Bryan Crane , Mark Wang , Stanley S. Hong , Jason Harris , Matthew Hage , Mark J. Nibbe
IPC: C12Q1/68
CPC classification number: B01L3/527 , B01L3/502715 , B01L2200/16 , B01L2300/0877 , B01L2400/0487 , B01L2400/06 , C12Q1/6869 , C12Q1/6874 , G01N21/6428 , G01N21/6486 , G01N2021/0307 , G01N2021/0325 , G01N2021/058 , G01N2021/6417 , G01N2021/6441 , G01N2021/6482
Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.
Abstract translation: 一种检测装置，具有包括多个微量荧光计的读取头，所述多个微量荧光计定位成在公共平面中同时获取多个所述宽视场图像; 和（b）平移台，其配置成沿着位于公共平面中的基板移动读取头。 基底可以是包含在药筒中的流动池，药筒还包括用于（i）样品储存器的壳体; （ii）样品储存器和流动池之间的流体管线; （iii）与所述流动池流体连通的若干试剂储存器，（iv）至少一个构造成介导所述储存器与所述流动池之间的流体连通的阀; 和（v）至少一个压力源，其构造成将液体从储存器移动到流动池。 检测装置和盒可以一起使用或彼此独立使用。
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8.发明申请公开(公告)号：US20170246635A1
公开(公告)日：2017-08-31
申请号：US15594413
申请日：2017-05-12
Applicant: Illumina, Inc.
Inventor： Dale Buermann , John A. Moon , Bryan Crane , Mark Wang , Stanley S. Hong , Jason Harris , Matthew Hage , Mark J. Nibbe
Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.
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9.发明授权公开(公告)号：US09193996B2
公开(公告)日：2015-11-24
申请号：US13766413
申请日：2013-02-13
Applicant: ILLUMINA, INC.
Inventor： Dale Buermann , John A. Moon , Bryan Crane , Mark Wang , Stanley S. Hong , Jason Harris , Matthew Hage , Mark J. Nibbe
CPC classification number: B01L3/527 , B01L3/502715 , B01L2200/16 , B01L2300/0877 , B01L2400/0487 , B01L2400/06 , C12Q1/6869 , C12Q1/6874 , G01N21/6428 , G01N21/6486 , G01N2021/0307 , G01N2021/0325 , G01N2021/058 , G01N2021/6417 , G01N2021/6441 , G01N2021/6482
Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.
Abstract translation: 一种检测装置，具有包括多个微量荧光计的读取头，所述多个微量荧光计定位成在公共平面中同时获取多个所述宽视场图像; 和（b）平移台，其配置成沿着位于公共平面中的基板移动读取头。 基底可以是包含在药筒中的流动池，药筒还包括用于（i）样品储存器的壳体; （ii）样品储存器和流动池之间的流体管线; （iii）与所述流动池流体连通的若干试剂储存器，（iv）至少一个构造成介导所述储存器与所述流动池之间的流体连通的阀; 和（v）至少一个压力源，其构造成将液体从储存器移动到流动池。 检测装置和盒可以一起使用或彼此独立使用。
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10.发明授权公开(公告)号：US09650669B2
公开(公告)日：2017-05-16
申请号：US14335117
申请日：2014-07-18
Applicant: ILLUMINA, INC.
Inventor： Dale Buermann , John A. Moon , Bryan Crane , Mark Wang , Stanley S. Hong , Jason Harris , Matthew Hage , Mark J. Nibbe
CPC classification number: B01L3/527 , B01L3/502715 , B01L2200/16 , B01L2300/0877 , B01L2400/0487 , B01L2400/06 , C12Q1/6869 , C12Q1/6874 , G01N21/6428 , G01N21/6486 , G01N2021/0307 , G01N2021/0325 , G01N2021/058 , G01N2021/6417 , G01N2021/6441 , G01N2021/6482
Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.
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