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公开(公告)号：US20140295464A1
公开(公告)日：2014-10-02
申请号：US14305652
申请日：2014-06-16
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , G01N33/74 , G01N2333/58 , G01N2800/32
摘要： A method for determining the amount of NT-proBNP in blood samples from felines. The method includes detecting degradation products of feline NT-proBNP by various methods, including using antibodies, kits and devices.
摘要翻译： 用于确定来自猫科动物的血液样品中NT-proBNP的量的方法。 该方法包括通过各种方法检测猫NT-proBNP的降解产物，包括使用抗体，试剂盒和装置。
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公开(公告)号：US20220276263A1
公开(公告)日：2022-09-01
申请号：US17673876
申请日：2022-02-17
摘要： The present invention relates to methods for detecting and/or measuring alanine transaminase (ALT) activity, aspartate transaminase (AST) activity, alkaline phosphatase (ALP) activity, glucose levels, creatinine levels, urea levels, asymmetric dimethylarginine (ADMA) levels, and/or symmetrical dimethylarginine (SDMA) levels in a sample. The method allows all of the activities and analytes, or any combination of activities and analytes, to be measured in a single assay.
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公开(公告)号：US20200049719A1
公开(公告)日：2020-02-13
申请号：US16571345
申请日：2019-09-16
摘要： This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
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公开(公告)号：US20220082501A1
公开(公告)日：2022-03-17
申请号：US17232647
申请日：2021-04-16
发明人： Jennifer E. Gagner , Kiamars Hajizadeh , Evan M. Peck , James R. Salter , Paul J. Travers , Christopher P. Turmel , Yingzi Wu , Hongzhi Xie , Murthy V.S.N. Yerramilli
IPC分类号： G01N21/64 , G01N21/27 , G01N33/58 , G01N33/542 , C07D311/82
摘要： The present invention relates to a method and reagents for determining the presence of or the amount of an analyte in a sample.
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公开(公告)号：US20220221446A1
公开(公告)日：2022-07-14
申请号：US17705924
申请日：2022-03-28
IPC分类号： G01N33/53 , C07C279/12 , C07K16/44 , G01N33/68 , G01N33/543
摘要： Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
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公开(公告)号：US20180335423A1
公开(公告)日：2018-11-22
申请号：US15977284
申请日：2018-05-11
IPC分类号： G01N33/53 , G01N33/543 , C07C279/12 , C07K16/44 , G01N33/68
CPC分类号： G01N33/53 , C07C279/12 , C07K16/44 , G01N33/54366 , G01N33/6812
摘要： Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
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公开(公告)号：US20140242723A1
公开(公告)日：2014-08-28
申请号：US14192956
申请日：2014-02-28
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/53 , C07C279/12 , C07K16/44 , G01N33/54366 , G01N33/6812
摘要： Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
摘要翻译： 检测生物样品中对称二甲基精氨酸（SDMA）的方法。 SDMA类似物用于产生与不对称的二甲基精氨酸，精氨酸和单甲基精氨酸几乎没有或没有交叉反应性的抗SDMA抗体。 类似物具有受保护或游离的硫醇（-SH）基团或羟基（-OH）基团，其允许它们连接到合适的缀合靶标，其可以是例如含蛋白质的标记分子。 抗SDMA抗体可用于诊断免疫测定以诊断SDMA相关疾病和/或疾病。
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公开(公告)号：US20210275979A1
公开(公告)日：2021-09-09
申请号：US17194713
申请日：2021-03-08
发明人： Pamela Ann Cacavas , Lucius S. Fox , Robert W. Lachapelle , Wendy O'Malley LePage , Evan M. Peck , Dominic Pelletier , Eric Allen Steva , Murthy V.S.N. Yerramilli
摘要： A method using a chemical analyzer for removing a component of a liquid sample which may interfere with a test performed on a test assay includes the steps of adding the liquid sample to a sample cup, transferring a volume of the liquid sample to a mixing cup containing an IMAC (Immobilized Metal Affinity Chromatography) resin containing porous beads to form a sample/resin solution in the mixing cup, using a pipette of the chemical analyzer to repeatedly aspirate the sample/resin solution into a disposable pipette tip of the pipette and expelling the sample/resin solution from the pipette tip into the mixing cup to achieve a mixed sample/resin solution in the mixing cup, and allowing the mixed sample/resin solution in the mixing cup to rest undisturbed so that the interfering component of the liquid sample adheres to the porous beads and the beads settle to a bottom portion of the mixing cup, resulting in a refined liquid sample devoid of the interfering component and occupying an upper portion of the mixing cup for later dispensing on the test assay.
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9.发明申请公开(公告)号：US20170269101A1
公开(公告)日：2017-09-21
申请号：US15447789
申请日：2017-03-02
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C07K14/8139 , C07K16/38 , G01N2333/8139 , G01N2800/18 , G01N2800/347 , G01N2800/348 , G01N2800/52
摘要： The disclosure provides compositions and methods for the detection of renal disease and periodontal disease in mammals.
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公开(公告)号：US20130280740A1
公开(公告)日：2013-10-24
申请号：US13918531
申请日：2013-06-14
CPC分类号： G01N33/53 , C07C279/12 , C07K16/44 , G01N33/54366 , G01N33/6812
摘要： Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
摘要翻译： 检测生物样品中对称二甲基精氨酸（SDMA）的方法。 SDMA类似物用于产生与不对称的二甲基精氨酸，精氨酸和单甲基精氨酸几乎没有或没有交叉反应性的抗SDMA抗体。 类似物具有受保护或游离的硫醇（-SH）基团或羟基（-OH）基团，其允许它们连接到合适的缀合靶标，其可以是例如含蛋白质的标记分子。 抗SDMA抗体可用于诊断免疫测定以诊断SDMA相关疾病和/或疾病。
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