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公开(公告)号：US07960376B2
公开(公告)日：2011-06-14
申请号：US12207601
申请日：2008-09-10
IPC分类号： C07D279/16 , A61K31/5415
CPC分类号： C07D279/16 , C07D265/36 , C07D281/10 , C07D417/04 , C07D417/14
摘要： The present invention provides benzo-fused heterocyclic compounds having the structure of formula I, as well as prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof. The compounds directly or indirectly modulate the activity of one or more cannabinoid receptors and can be incorporated into pharmaceutical preparations that are useful for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.
摘要翻译： 本发明提供具有式I结构的苯并稠合杂环化合物，以及其前体药物，立体异构体，外消旋物，盐，水合物，溶剂化物，酸盐水合物和同构晶体形式。 化合物直接或间接调节一种或多种大麻素受体的活性，并且可以掺入可用于预防和治疗各种疾病和病症（包括疼痛，炎症和瘙痒）的药物制剂中。
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公开(公告)号：US20090149450A1
公开(公告)日：2009-06-11
申请号：US12337683
申请日：2008-12-18
申请人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary R. Gustafson , Robert Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin , Mary-Margaret E. Zablocki
发明人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary R. Gustafson , Robert Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin , Mary-Margaret E. Zablocki
IPC分类号： A61K31/4985 , C07D487/04 , A61K31/5377 , A61P25/00 , A61K31/551
CPC分类号： C07D487/04
摘要： The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
摘要翻译： 本发明提供了具有式I结构的取代的咪唑并杂环化合物。还提供式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂合物和立体异构体。该化合物可用作大麻素受体的调节剂和预防和治疗 的大麻素受体相关疾病和病症，如疼痛，炎症和瘙痒。
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公开(公告)号：US08835422B2
公开(公告)日：2014-09-16
申请号：US13126201
申请日：2009-12-01
申请人： Stephen J. O'Connor , Jason S. Newcom , Janet L. Ralbovsky , Gary R. Gustafson , R. Paul Beckett , Robert Zhiyong Luo
发明人： Stephen J. O'Connor , Jason S. Newcom , Janet L. Ralbovsky , Gary R. Gustafson , R. Paul Beckett , Robert Zhiyong Luo
IPC分类号： A61K31/553 , C07D498/04 , C07D487/04
CPC分类号： C07D487/04 , A61K31/553 , C07D498/04
摘要： The present invention provides substituted imidazoheterocycles having the general structure of formula I: wherein Y is chosen from —O—, —OCRgRh—, —CRgRhO—, —CRgRh—, —(CRgRh)2—, —NRi—, —CRgRhNRi— and —NRiCRgRh—. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
摘要翻译： 本发明提供了具有通式I的通式结构的取代的咪唑并杂环：其中Y选自-O - ， - OCRgRh - ， - CRgRhO-，-CRgRh-， - （CRgRh）2 - ， - NR1 - ，CRRRNRi-和 -NRiCRgRh-。 还提供了式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂合物和立体异构体。该化合物可用作大麻素受体的调节剂并用于预防和治疗大麻素受体相关疾病和病症，例如疼痛， 炎症和瘙痒。
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公开(公告)号：US20090075973A1
公开(公告)日：2009-03-19
申请号：US12207601
申请日：2008-09-10
IPC分类号： A61K31/554 , C07D279/16 , C07D265/36 , C07D411/02 , A61K31/536 , A61K31/5415 , A61P43/00 , C07D417/02 , C07D281/10
CPC分类号： C07D279/16 , C07D265/36 , C07D281/10 , C07D417/04 , C07D417/14
摘要： The present invention provides benzo-fused heterocyclic compounds having the structure of formula I, as well as prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof. The compounds directly or indirectly modulate the activity of one or more cannabinoid receptors and can be incorporated into pharmaceutical preparations that are useful for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.
摘要翻译： 本发明提供具有式I结构的苯并稠合杂环化合物，以及其前体药物，立体异构体，外消旋物，盐，水合物，溶剂化物，酸盐水合物和同构晶体形式。 化合物直接或间接调节一种或多种大麻素受体的活性，并且可以掺入可用于预防和治疗各种疾病和病症（包括疼痛，炎症和瘙痒）的药物制剂中。
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公开(公告)号：US06228882B1
公开(公告)日：2001-05-08
申请号：US09397765
申请日：1999-09-15
IPC分类号： A61K31351
CPC分类号： C07D309/36 , A61K31/366 , C07C45/29 , C07C45/298 , C07C45/30 , C07C47/21 , C07C57/66 , C07D309/38 , C07F7/0812 , C07F7/1804
摘要： The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
摘要翻译： 本发明提供了用于制备myxopyronins和珊瑚绿素的收敛过程，其用作抗菌治疗剂。 本发明还提供了可用于制备pyronin抗生素的新物质组合物。
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公开(公告)号：US20180183380A1
公开(公告)日：2018-06-28
申请号：US15736460
申请日：2016-06-09
申请人： Gary R. Gustafson
发明人： Gary R. Gustafson
CPC分类号： H02S10/30 , F24S10/70 , F24S10/72 , F24S20/40 , F24S20/63 , F24S30/425 , F24S80/30 , F24S2020/183 , H01L35/02 , H01L35/32 , H02S20/30 , H02S40/42 , H02S40/425 , H02S40/44 , Y02B10/20 , Y02E10/44 , Y02E10/47
摘要： The present invention is an apparatus and method using solar insolation to heat fluid moving through panels, resulting in relatively hot fluid. A set of such panels might be installed in a window. Heat is removed from the hot fluid in a heat reservoir or heat sink, resulting in relatively cool fluid. In some embodiments, the hot fluid and the cool fluid are placed in thermal contact with opposite sides of a thermoelectric generator, thereby generating electricity. In some embodiments, photovoltaic cell modules are embedded in the panels, the fluid system improving the effectiveness of the cells. A given system might use either approach to generate electricity, or both. Heat from the heat reservoir might be used to heat a building. A thermoelectric system might be run in reverse at night.
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公开(公告)号：US20090247502A1
公开(公告)日：2009-10-01
申请号：US12409626
申请日：2009-03-24
IPC分类号： A61K31/5383 , C07D498/04
CPC分类号： C07D498/04
摘要： The invention provides compounds having the structure of formula I, and prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof, wherein A, Y and the groups R1, R2, R3 and R4 are defined in the specification. These compounds can be administered in pharmaceutical formulations to modulate cannabinoid receptor activity for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.
摘要翻译： 本发明提供了具有式I结构的化合物及其前体药物，立体异构体，外消旋物，盐，水合物，溶剂合物，酸盐水合物和同构晶体形式，其中A，Y和基团R 1，R 2，R 3和R 4定义在 规格。 这些化合物可以在药物制剂中施用以调节大麻素受体活性，以预防和治疗各种疾病和病症，包括疼痛，炎症和瘙痒。
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公开(公告)号：US6022983A
公开(公告)日：2000-02-08
申请号：US2541
申请日：1998-01-02
IPC分类号： C07D309/38 , A61K31/351 , A61K31/366 , A61P31/04 , C07C45/29 , C07C45/30 , C07C45/38 , C07C47/21 , C07C49/203 , C07C57/66 , C07D309/36 , C07F7/08 , C07F7/18 , C07C33/03 , C07C45/26 , C07C67/30 , C07D309/32
CPC分类号： C07D309/36 , A61K31/366 , C07C45/29 , C07C45/298 , C07C45/30 , C07C47/21 , C07C57/66 , C07D309/38 , C07F7/0812 , C07F7/1856
摘要： The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
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公开(公告)号：US5942547A
公开(公告)日：1999-08-24
申请号：US709343
申请日：1996-09-06
IPC分类号： C12Q1/70 , A61K31/00 , A61K31/155 , A61K31/44 , A61K31/4406 , A61P31/00 , A61P31/18 , C07B61/00 , C07C215/44 , C07C215/50 , C07C217/58 , C07C233/41 , C07C233/79 , C07C235/54 , C07C257/18 , C07C271/22 , C07C271/24 , C07C271/34 , C07C275/26 , C07C279/14 , C07C279/22 , C07C311/20 , C07D207/32 , C07D213/82 , C07D401/14 , C07D405/14 , C07D498/04 , C07K1/113 , C08F8/30 , A61K31/16 , C07C233/00
CPC分类号： C07D207/32 , C07C215/44 , C07C215/50 , C07C217/58 , C07C233/41 , C07C233/79 , C07C235/54 , C07C257/18 , C07C271/22 , C07C271/24 , C07C271/34 , C07C279/14 , C07C279/22 , C07C311/20 , C07D401/14 , C07D405/14 , C07C2101/14 , C40B40/00 , G01N2333/163
摘要： This invention provides a compound having the formula: ##STR1## wherein R.sup.1 and R.sup.3 independently are hydrogen, --CHO, --COCH.sub.3, --COR.sup.7, --A--Ar--(Q).sub.z, etc.; wherein D is a C.sub.1-6 linear, C.sub.3-8 branched or cyclic group having from 4 to about 15 atoms, consisting of C, etc.; wherein D is unsubstituted or substituted with one or more groups independently selected from the group consisting of --OH, NH.sub.2, --NHR.sub.7, etc.; wherein each Q is independently --CNH(NHY), --NHCNH(NHY), --SO.sub.2 W, --SOW, etc.; wherein Y is hydrogen, alkyl, alkenyl, --B--NH.sub.2, --B--NHR.sup.8, etc.; wherein W is alkyl, alkenyl, --B--NH.sub.2, etc.; wherein A nd B independently are a bond, or a C.sub.1-6 linear, C.sub.3-8 branched or cyclic linking group having from 1 to about 15 atoms, consisting of C, optionally interrupted by N, S, P and O; wherein A and B independently are unsubstituted or substituted with --OH, NH.sub.2, etc.; wherein R.sup.7 is an alkyl, a branched alkyl, etc.; wherein R.sup.8, R.sup.9, and R.sup.10 are independently represented by hydrogen, alkyl, branched alkyl, etc.; wherein x is 0, 1 or 2; and z is 0, 1, 2, or 4; wherein R.sup.1 ' and R.sup.3 ' are independently selected from the group consisting of hydrogen, alkyl and benzyl, or alternatively, R.sup.1 and R.sup.1 ' or R.sup.3 and R.sup.3 ' with their respective nitrogen atoms independently form a phthalimido, succinimido, etc.; wherein R.sup.4, R.sup.5, and R.sup.6 independently are selected from the group consisting of hydrogen, --CHO, --COCH.sub.3, --COR.sup.7, etc.; therein said saccharides are optionally linked at the one position of said saccharid group; wherein R.sup.4 and R.sup.5, or R.sup.5 and R.sup.6, together comprise a methylidene, ethylidene, isopropylident, cyclohexylidene or benzylidene bridge, or R.sup.3 and R.sup.4, or R.sup.1 and R.sup.6, together independently form an intramolecular carbamate; wherein R.sup.5 is not hydrogen or glycosyl when R.sup.3 and R.sup.4, or R.sup.1 and R.sup.6, together independently form an intramolecular carbamate; with the provisio that at least two of R.sup.1, R.sup.1 ', R.sup.3, R.sup.3 ', R.sup.4, R.sup.5, and R.sup.6 are not hydrogen. Also provided are pharmaceutical compositions comprising the compound and methods of inhibiting binding of human immunodeficiency virus REV protein to RRE.
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10.发明申请公开(公告)号：US20080161340A1
公开(公告)日：2008-07-03
申请号：US12004134
申请日：2007-12-19
申请人： Gary R. Gustafson , R. Paul Beckett
发明人： Gary R. Gustafson , R. Paul Beckett
IPC分类号： A61K31/444 , C07D215/00 , A61K31/47 , C07D401/00 , C07D471/02 , A61K31/497
CPC分类号： C07D215/227 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04
摘要： Tetrahydroquinolinone and tetrahydronaphthyridone cannabinoid receptor ligand compounds and stereoisomers, mixtures of stereoisomers, prodrugs, pharmaceutically acceptable salts, hydrates, solvates, acid salt hydrates, and isomorphic crystalline forms thereof are described. The compounds conform to the structure of formula I:
摘要翻译： 四氢喹啉酮和四氢萘吡酮大麻素受体配体化合物和立体异构体，立体异构体的混合物，前药，药学上可接受的盐，水合物，溶剂合物，酸盐水合物和同构晶体形式。 化合物符合式I的结构：
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