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1.发明申请Methods for inhibiting mesenchymal phenotype after epithelial-to-mesenchymal transition 审中-公开抑制上皮 - 间质转化后间质表型的方法公开(公告)号：US20160184274A1
公开(公告)日：2016-06-30
申请号：US14983679
申请日：2015-12-30
发明人： Juan Saus , Fernando Revert , Aida Artigot , Francisco Revert-Ros , Ernesto Lopez-Pascual , Raul Blasco , Nuria Roda , Juan F. Sanz-Cervera , Roberto Gozalbo-Rovira
IPC分类号： A61K31/4188 , A61K31/192 , G01N33/574 , C07K16/18
CPC分类号： A61K31/4188 , A01K67/0271 , A01K67/0276 , A01K2207/12 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , A61K31/192 , A61K31/194 , A61K31/216 , A61K31/357 , A61K31/4418 , A61K2039/505 , C07K16/18 , C07K16/40 , C07K2317/76 , C12N9/12 , C12Y207/11009 , G01N33/57415 , G01N33/57423 , G01N33/57496 , G01N33/6893 , G01N2458/00 , G01N2800/102 , G01N2800/12 , G01N2800/347
摘要： Methods of using inhibitors of Goodpasture Antigen Binding Protein for inhibiting mesenchymal phenotype after epithelial-to-mesenchymal transition (EMT), treating an invasive tumor, and detecting EMT in a tissue are described.
摘要翻译： 描述了使用Goodpasture抗原结合蛋白抑制剂抑制上皮 - 间质转化（EMT）后的间质表型，治疗浸润性肿瘤和检测组织中EMT的方法。
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公开(公告)号：US20160083327A1
公开(公告)日：2016-03-24
申请号：US14944721
申请日：2015-11-18
申请人： FIBROSTATIN, S.L.
发明人： Juan Saus , Santos Fustero , Juan F. Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号： C07C59/52 , C07D213/55 , C07C69/732 , C07C69/734 , C07C67/313
CPC分类号： C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C67/313 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58
摘要： Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
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公开(公告)号：US20180179139A1
公开(公告)日：2018-06-28
申请号：US15892317
申请日：2018-02-08
申请人： FibroStatin, S.L.
发明人： Juan Saus , Santos Fustero , Juan F. Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号： C07C59/52 , C07D213/58 , C07D213/55 , C07D213/48 , C07D213/34 , C07D213/26 , C07C309/65 , C07C45/68 , C07C69/734 , C07C69/732 , C07C67/313 , C07C59/70 , C07C59/64 , C07C59/56 , C07C69/738
CPC分类号： C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C67/313 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58
摘要： Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
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公开(公告)号：US09199936B2
公开(公告)日：2015-12-01
申请号：US14063709
申请日：2013-10-25
申请人： FibroStatin, S.L.
发明人： Juan Saus , Santos Fustero , Juan F Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号： C07C43/23 , C07C59/90 , C07C43/225 , C07D213/58 , C07C45/68 , C07C47/565 , C07C59/52 , C07C59/56 , C07C59/64 , C07C59/70 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55
CPC分类号： C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C67/313 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58
摘要： Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
摘要翻译： 公开的是下式的化合物：抑制GPBP活性，使其可用作抗体介导的病症，耐药性癌症，炎症，蛋白质错误折叠和ER应激介导的病症以及异常凋亡中的治疗剂。
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公开(公告)号：US09066938B2
公开(公告)日：2015-06-30
申请号：US13933609
申请日：2013-07-02
发明人： Juan Saus , Francisco Revert-Ros , Fernando Revert , Carmen Aguado-Velasco , Ernesto López-Pascual , Alejandra María Pérez-Sastre , Raúl Blasco , Héctor Pérez-Montoyo
IPC分类号： A01N43/04 , A61K31/70 , A61K31/4406 , A61K31/704 , A61K31/357 , A61K31/192 , A61K31/194 , A61K31/216 , A61K45/06 , A61K31/4418
CPC分类号： A61K31/4406 , A61K31/192 , A61K31/194 , A61K31/216 , A61K31/357 , A61K31/4418 , A61K31/704 , A61K45/06 , A61K2300/00
摘要： The present invention provides compositions including anti-tumor agents and inhibitors of Goodpasture antigen binding protein, p21, and ABCC7, and their use in treating cancer.
摘要翻译： 本发明提供包含抗肿瘤剂和Goodpasture抗原结合蛋白p21和ABCC7抑制剂的组合物及其在治疗癌症中的用途。
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公开(公告)号：US10544083B2
公开(公告)日：2020-01-28
申请号：US15892317
申请日：2018-02-08
申请人： FibroStatin, S.L.
发明人： Juan Saus , Santos Fustero , Juan F. Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号： C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58 , C07C67/313
摘要： Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
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公开(公告)号：US20170218088A1
公开(公告)日：2017-08-03
申请号：US15485827
申请日：2017-04-12
申请人： Fibrostatin S.L.
IPC分类号： C07K16/40 , G01N33/68 , A61K31/352 , G01N33/573 , A61K38/16 , A61K31/4409
CPC分类号： C07K16/40 , A61K31/352 , A61K31/353 , A61K31/4409 , A61K38/16 , A61K2039/505 , C07K2317/76 , C12Y207/11009 , G01N33/573 , G01N33/6893 , G01N2333/4737 , G01N2333/912 , G01N2800/12
摘要： The present invention provides methods for the diagnosis and/or treatment of chronic kidney disease, immune complex-mediated GN, rheumatoid arthritis, and pulmonary fibrosis, and methods for identifying compounds for such therapeutic use.
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公开(公告)号：US20140080852A1
公开(公告)日：2014-03-20
申请号：US14063709
申请日：2013-10-25
申请人： FIBROSTATIN, S.L.
发明人： Juan Saus , Santos Fustero , Juan F Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号： C07D213/58
CPC分类号： C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C67/313 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58
摘要： Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
摘要翻译： 公开的是下式的化合物：抑制GPBP活性，使其可用作抗体介导的病症，耐药性癌症，炎症，蛋白质错误折叠和ER应激介导的病症以及异常凋亡中的治疗剂。
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