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公开(公告)号:US20160083327A1
公开(公告)日:2016-03-24
申请号:US14944721
申请日:2015-11-18
申请人: FIBROSTATIN, S.L.
发明人: Juan Saus , Santos Fustero , Juan F. Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号: C07C59/52 , C07D213/55 , C07C69/732 , C07C69/734 , C07C67/313
CPC分类号: C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C67/313 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58
摘要: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
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公开(公告)号:US10544083B2
公开(公告)日:2020-01-28
申请号:US15892317
申请日:2018-02-08
申请人: FibroStatin, S.L.
发明人: Juan Saus , Santos Fustero , Juan F. Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号: C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58 , C07C67/313
摘要: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
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公开(公告)号:US20140080852A1
公开(公告)日:2014-03-20
申请号:US14063709
申请日:2013-10-25
申请人: FIBROSTATIN, S.L.
发明人: Juan Saus , Santos Fustero , Juan F Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号: C07D213/58
CPC分类号: C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C67/313 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58
摘要: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
摘要翻译: 公开的是下式的化合物:抑制GPBP活性,使其可用作抗体介导的病症,耐药性癌症,炎症,蛋白质错误折叠和ER应激介导的病症以及异常凋亡中的治疗剂。
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公开(公告)号:US20180179139A1
公开(公告)日:2018-06-28
申请号:US15892317
申请日:2018-02-08
申请人: FibroStatin, S.L.
发明人: Juan Saus , Santos Fustero , Juan F. Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号: C07C59/52 , C07D213/58 , C07D213/55 , C07D213/48 , C07D213/34 , C07D213/26 , C07C309/65 , C07C45/68 , C07C69/734 , C07C69/732 , C07C67/313 , C07C59/70 , C07C59/64 , C07C59/56 , C07C69/738
CPC分类号: C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C67/313 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58
摘要: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
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公开(公告)号:US09199936B2
公开(公告)日:2015-12-01
申请号:US14063709
申请日:2013-10-25
申请人: FibroStatin, S.L.
发明人: Juan Saus , Santos Fustero , Juan F Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号: C07C43/23 , C07C59/90 , C07C43/225 , C07D213/58 , C07C45/68 , C07C47/565 , C07C59/52 , C07C59/56 , C07C59/64 , C07C59/70 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55
CPC分类号: C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C67/313 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58
摘要: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
摘要翻译: 公开的是下式的化合物:抑制GPBP活性,使其可用作抗体介导的病症,耐药性癌症,炎症,蛋白质错误折叠和ER应激介导的病症以及异常凋亡中的治疗剂。
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