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公开(公告)号：US20180179139A1
公开(公告)日：2018-06-28
申请号：US15892317
申请日：2018-02-08
申请人： FibroStatin, S.L.
发明人： Juan Saus , Santos Fustero , Juan F. Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号： C07C59/52 , C07D213/58 , C07D213/55 , C07D213/48 , C07D213/34 , C07D213/26 , C07C309/65 , C07C45/68 , C07C69/734 , C07C69/732 , C07C67/313 , C07C59/70 , C07C59/64 , C07C59/56 , C07C69/738
CPC分类号： C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C67/313 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58
摘要： Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
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公开(公告)号：US10544083B2
公开(公告)日：2020-01-28
申请号：US15892317
申请日：2018-02-08
申请人： FibroStatin, S.L.
发明人： Juan Saus , Santos Fustero , Juan F. Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号： C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58 , C07C67/313
摘要： Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
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3.发明申请Methods for inhibiting mesenchymal phenotype after epithelial-to-mesenchymal transition 审中-公开抑制上皮 - 间质转化后间质表型的方法公开(公告)号：US20160184274A1
公开(公告)日：2016-06-30
申请号：US14983679
申请日：2015-12-30
发明人： Juan Saus , Fernando Revert , Aida Artigot , Francisco Revert-Ros , Ernesto Lopez-Pascual , Raul Blasco , Nuria Roda , Juan F. Sanz-Cervera , Roberto Gozalbo-Rovira
IPC分类号： A61K31/4188 , A61K31/192 , G01N33/574 , C07K16/18
CPC分类号： A61K31/4188 , A01K67/0271 , A01K67/0276 , A01K2207/12 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , A61K31/192 , A61K31/194 , A61K31/216 , A61K31/357 , A61K31/4418 , A61K2039/505 , C07K16/18 , C07K16/40 , C07K2317/76 , C12N9/12 , C12Y207/11009 , G01N33/57415 , G01N33/57423 , G01N33/57496 , G01N33/6893 , G01N2458/00 , G01N2800/102 , G01N2800/12 , G01N2800/347
摘要： Methods of using inhibitors of Goodpasture Antigen Binding Protein for inhibiting mesenchymal phenotype after epithelial-to-mesenchymal transition (EMT), treating an invasive tumor, and detecting EMT in a tissue are described.
摘要翻译： 描述了使用Goodpasture抗原结合蛋白抑制剂抑制上皮 - 间质转化（EMT）后的间质表型，治疗浸润性肿瘤和检测组织中EMT的方法。
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公开(公告)号：US20160083327A1
公开(公告)日：2016-03-24
申请号：US14944721
申请日：2015-11-18
申请人： FIBROSTATIN, S.L.
发明人： Juan Saus , Santos Fustero , Juan F. Sanz-Cervera , Enrique Pérez-Payá , Raül Blasco , Francisco Revert-Ros , Fernando Revert
IPC分类号： C07C59/52 , C07D213/55 , C07C69/732 , C07C69/734 , C07C67/313
CPC分类号： C07C59/52 , C07C45/68 , C07C47/565 , C07C59/56 , C07C59/64 , C07C59/70 , C07C67/313 , C07C69/732 , C07C69/734 , C07C69/738 , C07C309/65 , C07D213/26 , C07D213/34 , C07D213/48 , C07D213/55 , C07D213/58
摘要： Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
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