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公开(公告)号：US09061066B2
公开(公告)日：2015-06-23
申请号：US13701882
申请日：2011-06-06
CPC分类号： A61K47/36 , A61K39/39 , A61K2039/55583
摘要： Cyclic beta glucan compounds function as an immunoadjuvant when administered prior to, concommitantly with, or subsequent to the administration of one or more antigens to a subject. These adjuvant compounds may be effectively used as dendritic cell activating molecules.
摘要翻译： 当向受试者施用一种或多种抗原之前，同时或之后施用时，β-葡聚糖化合物作为免疫佐剂起作用。 这些佐剂化合物可以有效地用作树枝状细胞活化分子。
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2.发明申请VACCINES BASED ON TARGETING ANTIGEN TO DCIR EXPRESSED ON ANTIGEN-PRESENTING CELLS 有权基于抗原向抗原呈递细胞表达的DCIR的抗生素疫苗公开(公告)号：US20140134168A1
公开(公告)日：2014-05-15
申请号：US14045454
申请日：2013-10-03
申请人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
发明人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： A61K39/21 , A61K39/145
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
摘要翻译： 本发明包括使用形成抗体 - 抗原复合物的抗原附着的DCIR特异性抗体或其片段增加抗原呈递的有效性的组合物和方法，其中所述抗原由具有抗体 - 抗原复合物的树突状细胞加工和呈递， 与抗体 - 抗原复合物接触。
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公开(公告)号：US20110081343A1
公开(公告)日：2011-04-07
申请号：US12882052
申请日：2010-09-14
IPC分类号： A61K39/395 , C12N15/63 , C12P21/00 , C12N9/02 , C12N9/10 , C12P21/02 , C12Q1/02 , C12N5/0783 , C12N5/0781 , C07K16/18 , C07H21/00 , C07K19/00 , A61P35/00 , A61P37/04 , A61P35/02
CPC分类号： C07K16/2896 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/21 , A61K2039/505 , A61K2039/5154 , A61K2039/55561 , A61K2039/6056 , C07K14/005 , C07K14/4748 , C07K16/2851 , C07K2319/00 , C07K2319/33 , C12N7/00 , C12N2740/16034 , C12N2760/16134
摘要： The present invention includes isolated anti-Langerin vaccines, methods for making and using an isolated anti-Langerin antibody or binding fragment thereof and one or more antigenic peptides at the carboxy-terminus of the isolated anti-Langerin antibody, wherein when two or more antigenic peptides are present, the peptides are separated by the one or more linker peptides that comprise at least one glycosylation site. The present invention also includes isolated vectors for the expression of the anti-Langerin antigen delivery vectors and their manufactures and use.
摘要翻译： 本发明包括分离的抗兰格林疫苗，分离的抗 - 兰格林抗体的羧基末端制备和使用分离的抗 - 兰格林抗体或其结合片段和一种或多种抗原肽的方法，其中当两种或多种抗原 存在肽，肽被包含至少一个糖基化位点的一个或多个接头肽隔开。 本发明还包括用于表达抗Langerin抗原递送载体的分离载体及其制备和用途。
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公开(公告)号：US11369663B2
公开(公告)日：2022-06-28
申请号：US16308002
申请日：2017-06-07
申请人： Eynav Klechevsky
发明人： Eynav Klechevsky
IPC分类号： A61K38/20 , A61K38/19 , A61K45/06 , G01N33/569 , A61P37/02 , G01N33/50 , A61K38/21 , A61P17/06 , A61P35/00 , A61K35/15 , A61K39/395 , C12N5/0784
摘要： The present disclosure provides for methods and compositions for the modulation of CD5 in a subject. Also provided are methods of detecting and monitoring diseases, such as inflammatory and autoimmune diseases.
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5.发明授权Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells 有权基于在抗原呈递细胞上表达的针对DCIR的靶向抗原的疫苗公开(公告)号：US08057798B2
公开(公告)日：2011-11-15
申请号：US12024897
申请日：2008-02-01
申请人： Gerald Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
发明人： Gerald Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： A61K39/395 , A61K39/21 , C07K16/46 , C07K16/28
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
摘要翻译： 本发明包括使用形成抗体 - 抗原复合物的抗原附着的DCIR特异性抗体或其片段增加抗原呈递的有效性的组合物和方法，其中所述抗原由具有抗体 - 抗原复合物的树突状细胞加工和呈递， 与抗体 - 抗原复合物接触。
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公开(公告)号：US08449888B2
公开(公告)日：2013-05-28
申请号：US13234914
申请日：2011-09-16
申请人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
发明人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： A61K39/395 , A61K39/12 , C07K16/46 , C07K16/28
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
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公开(公告)号：US20130129756A1
公开(公告)日：2013-05-23
申请号：US13701882
申请日：2011-06-06
CPC分类号： A61K47/36 , A61K39/39 , A61K2039/55583
摘要： The present invention relates to a cyclic beta glucan compound for use as an immuno adjuvant and vaccine composition comprising thereof. These novel adjuvant compounds represent in particular a new class of dendritic cell activating molecules.
摘要翻译： 本发明涉及用作免疫佐剂的环状β-葡聚糖化合物和包含其的疫苗组合物。 这些新型佐剂化合物特别代表了一类新型的树突细胞活化分子。
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公开(公告)号：US20120237513A1
公开(公告)日：2012-09-20
申请号：US13454404
申请日：2012-04-24
IPC分类号： A61K39/395 , A61P37/04 , C07K19/00
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
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9.发明授权Multivariable antigens complexed with targeting humanized monoclonal antibody 有权与靶向人源化单克隆抗体复合的多变量抗原公开(公告)号：US07786267B2
公开(公告)日：2010-08-31
申请号：US12024036
申请日：2008-01-31
CPC分类号： C07K16/28 , A61K39/44 , C07K14/33 , C07K16/00 , C07K2317/24 , C07K2317/35 , C07K2317/54 , C07K2317/55 , C07K2319/00 , C07K2319/33 , Y02A50/472
摘要： The present invention includes compositions and methods for designing, making and using modular recombinant antibodies or fragments thereof with one half of a cohesin-dockerin pair that permits the rapid assembly of multivariant antigen conjugates.
摘要翻译： 本发明包括用于设计，制造和使用模块化重组抗体或其片段的组合物和方法，所述重组抗体或其片段具有允许多变抗原缀合物的快速装配的粘稠素 - 停泊聚糖对的一半。
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10.发明申请ANTI-CD8 ANTIBODIES BLOCK PRIMING OF CYTOTOXIC EFFECTORS AND LEAD TO GENERATION OF REGULATORY CD8+ T CELLS 审中-公开抗CD8抗体阻断细胞毒性作用的细胞因子并导致调节性CD8 + T细胞的产生公开(公告)号：US20090304659A1
公开(公告)日：2009-12-10
申请号：US12479349
申请日：2009-06-05
CPC分类号： C07K16/2815 , A61K39/001 , A61K2035/122 , A61K2039/505 , C07K2317/73 , C12N5/0636 , C12N5/064 , C12N2501/22 , C12N2501/24 , C12N2501/26 , C12N2501/505
摘要： The present invention includes compositions and methods for inducing tolerance in a subject in need thereof comprising providing the subject with an effective amount of an anti-CD8 antibody sufficient in induce CD8+ T cell immune tolerance to allogeneic antigens.
摘要翻译： 本发明包括用于在有需要的受试者中诱导耐受性的组合物和方法，其包括向受试者提供有效量的足以诱导对同种异体抗原的CD8 + T细胞免疫耐受的抗CD8抗体。
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