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1.发明申请VACCINES BASED ON TARGETING ANTIGEN TO DCIR EXPRESSED ON ANTIGEN-PRESENTING CELLS 有权基于抗原向抗原呈递细胞表达的DCIR的抗生素疫苗公开(公告)号：US20140134168A1
公开(公告)日：2014-05-15
申请号：US14045454
申请日：2013-10-03
申请人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
发明人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： A61K39/21 , A61K39/145
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
摘要翻译： 本发明包括使用形成抗体 - 抗原复合物的抗原附着的DCIR特异性抗体或其片段增加抗原呈递的有效性的组合物和方法，其中所述抗原由具有抗体 - 抗原复合物的树突状细胞加工和呈递， 与抗体 - 抗原复合物接触。
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公开(公告)号：US08449888B2
公开(公告)日：2013-05-28
申请号：US13234914
申请日：2011-09-16
申请人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
发明人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： A61K39/395 , A61K39/12 , C07K16/46 , C07K16/28
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
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公开(公告)号：US20120237513A1
公开(公告)日：2012-09-20
申请号：US13454404
申请日：2012-04-24
IPC分类号： A61K39/395 , A61P37/04 , C07K19/00
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
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4.发明授权Multivariable antigens complexed with targeting humanized monoclonal antibody 有权与靶向人源化单克隆抗体复合的多变量抗原公开(公告)号：US07786267B2
公开(公告)日：2010-08-31
申请号：US12024036
申请日：2008-01-31
CPC分类号： C07K16/28 , A61K39/44 , C07K14/33 , C07K16/00 , C07K2317/24 , C07K2317/35 , C07K2317/54 , C07K2317/55 , C07K2319/00 , C07K2319/33 , Y02A50/472
摘要： The present invention includes compositions and methods for designing, making and using modular recombinant antibodies or fragments thereof with one half of a cohesin-dockerin pair that permits the rapid assembly of multivariant antigen conjugates.
摘要翻译： 本发明包括用于设计，制造和使用模块化重组抗体或其片段的组合物和方法，所述重组抗体或其片段具有允许多变抗原缀合物的快速装配的粘稠素 - 停泊聚糖对的一半。
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公开(公告)号：US08586052B2
公开(公告)日：2013-11-19
申请号：US13454404
申请日：2012-04-24
申请人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
发明人： Gerard Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： A61K39/12 , A61K39/145 , A61K39/21 , A61K39/395 , C07K16/46 , C07K16/28
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
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6.发明申请Vaccines Based on Targeting Antigen to DCIR Expressed on Antigen-Presenting Cells 失效基于抗原向抗原呈递细胞的DCIR靶向疫苗的疫苗公开(公告)号：US20120004643A1
公开(公告)日：2012-01-05
申请号：US13234914
申请日：2011-09-16
IPC分类号： A61M37/00 , C12N5/0784 , A61K39/395 , C12N5/071 , C07K16/28 , C07H3/00
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
摘要翻译： 本发明包括使用形成抗体 - 抗原复合物的抗原附着的DCIR特异性抗体或其片段增加抗原呈递的有效性的组合物和方法，其中所述抗原由具有抗体 - 抗原复合物的树突状细胞加工和呈递， 与抗体 - 抗原复合物接触。
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7.发明申请Multivariable Antigens Complexed with Targeting Humanized Monoclonal Antibody 审中-公开与靶向人源化单克隆抗体复合的多变量抗原公开(公告)号：US20100330115A1
公开(公告)日：2010-12-30
申请号：US12819618
申请日：2010-06-21
IPC分类号： A61K39/385 , G01N33/567 , C12P21/06 , C12N5/10 , C12N15/63 , A61K38/00 , A61P31/00 , A61P35/00 , C07K14/00 , C07K16/00 , C07K1/14 , C07H21/00 , A61P37/06
CPC分类号： C07K16/28 , A61K39/44 , C07K14/33 , C07K16/00 , C07K2317/24 , C07K2317/35 , C07K2317/54 , C07K2317/55 , C07K2319/00 , C07K2319/33
摘要： The present invention includes compositions and methods for designing, making and using modular recombinant antibodies or fragments thereof with one half of a cohesin-dockerin pair that permits the rapid assembly of multivariant antigen conjugates.
摘要翻译： 本发明包括用于设计，制备和使用模块化重组抗体或其片段的组合物和方法，所述重组抗体或其片段具有允许快速组装多变抗原缀合物的粘稠蛋白 - 停泊聚糖对的一半。
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8.发明授权Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells 有权基于在抗原呈递细胞上表达的针对DCIR的靶向抗原的疫苗公开(公告)号：US08057798B2
公开(公告)日：2011-11-15
申请号：US12024897
申请日：2008-02-01
申请人： Gerald Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
发明人： Gerald Zurawski , Jacques F. Banchereau , Eynav Klechevsky , Sandra Zurawski , Anne-Laure Flamar
IPC分类号： A61K39/395 , A61K39/21 , C07K16/46 , C07K16/28
CPC分类号： C07K16/2851 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K47/6897 , A61K47/6901 , A61K2039/505 , A61K2039/6056 , B82Y5/00 , C12N5/0639 , C12N2760/16134
摘要： The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
摘要翻译： 本发明包括使用形成抗体 - 抗原复合物的抗原附着的DCIR特异性抗体或其片段增加抗原呈递的有效性的组合物和方法，其中所述抗原由具有抗体 - 抗原复合物的树突状细胞加工和呈递， 与抗体 - 抗原复合物接触。
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公开(公告)号：US20100322929A1
公开(公告)日：2010-12-23
申请号：US12717778
申请日：2010-03-04
申请人： Gerard Zurawski , Jacques F. Banchereau , Anne-Laure Flamar , Yves Levy , Monica Montes , Peter Klucar , Keiko Akagawa
发明人： Gerard Zurawski , Jacques F. Banchereau , Anne-Laure Flamar , Yves Levy , Monica Montes , Peter Klucar , Keiko Akagawa
CPC分类号： A61K39/0011 , A61K2039/6056 , C07K14/435 , C07K16/2878 , C07K2319/00 , C07K2319/33 , C07K2319/91 , Y02A50/39 , Y02A50/466
摘要： The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
摘要翻译： 本发明包括用于表达，分泌和使用用作例如疫苗和抗原递送载体的用于将抗原递送至抗原呈递细胞的组合物和方法。 在一个实施方案中，载体是抗CD40抗体或其片段，以及与抗-CD40抗体或其片段（包括人源化抗体）连接的一个或多个抗原肽。
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公开(公告)号：US20100291082A1
公开(公告)日：2010-11-18
申请号：US12717804
申请日：2010-03-04
IPC分类号： A61K39/395 , C07K16/46 , C12N15/63 , C12P21/00 , C12N5/0783 , A61P37/04 , A61P31/12 , A61P31/18
CPC分类号： C07K16/2878 , A61K39/00 , A61K39/385 , A61K2039/6056 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K16/00 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/77 , C07K2317/80 , C07K2319/00 , C07K2319/30 , C07K2319/40 , C07K2319/91 , C12N2740/16222 , C12N2740/16322 , C12N2760/16122 , C12N2770/24222 , C12N2770/24234 , G01N33/6863 , Y02A50/39 , Y02A50/464 , Y02A50/466
摘要： The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
摘要翻译： 本发明包括用于表达，分泌和使用用作例如疫苗和抗原递送载体的用于将抗原递送至抗原呈递细胞的组合物和方法。 在一个实施方案中，载体是抗CD40抗体或其片段，以及与抗-CD40抗体或其片段（包括人源化抗体）连接的一个或多个抗原肽。
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