公开(公告)号：US20210062168A1

公开(公告)日：2021-03-04

申请号：US17005913

申请日：2020-08-28

Applicant: Codexis, Inc. ,  Societe des Produits Nestle S.A.

Inventor： Chinping Chng ,  William Casey Hallows ,  Judy Victoria Antonio Viduya ,  Nikki Dellas ,  Stephanie Sue Galanie ,  Kristen Jean Vallieu

IPC: C12N9/20 ,  A61K38/46 ,  A61P5/48 ,  A61K9/48

Abstract: The present invention provides engineered lipase polypeptides and compositions thereof. The engineered lipase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH 7) conditions. The invention also relates to the use of the compositions comprising the engineered lipase polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered lipase polypeptides, as well as methods for making the engineered polynucleotides and lipase polypeptides.

公开(公告)号：US11987823B2

公开(公告)日：2024-05-21

申请号：US17005913

申请日：2020-08-28

Applicant: Societe des Produits Nestle S.A.

Inventor： Chinping Chng ,  William Casey Hallows ,  Judy Victoria Antonio Viduya ,  Nikki Dellas ,  Stephanie Sue Galanie ,  Kristen Jean Vallieu

IPC: C12N9/20 ,  A61K9/48 ,  A61K38/46 ,  A61P5/48

CPC classification number: C12N9/20 ,  A61K9/4883 ,  A61K38/465 ,  A61P5/48

Abstract: The present invention provides engineered lipase polypeptides and compositions thereof. The engineered lipase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH 7) conditions. The invention also relates to the use of the compositions comprising the engineered lipase polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered lipase polypeptides, as well as methods for making the engineered polynucleotides and lipase polypeptides.

公开(公告)号：US20240263156A1

公开(公告)日：2024-08-08

申请号：US18630219

申请日：2024-04-09

Applicant: SOCIETE DES PRODUITS NESTLE S.A.

Inventor： Chinping Chng ,  William Casey Hallows ,  Judy Victoria Antonio Viduya ,  Nikki Dellas ,  Stephanie Sue Galanie ,  Kristen Jean Vallieu

IPC: C12N9/20 ,  A61K9/48 ,  A61K38/46 ,  A61P5/48

CPC classification number: C12N9/20 ,  A61K9/4883 ,  A61K38/465 ,  A61P5/48

Abstract: Engineered lipase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH 7) conditions. Compositions containing the engineered lipase polypeptides can be used for therapeutic and/or nutritional purposes. Polynucleotides encoding the engineered lipase polypeptides are also provided, as well as methods for making the engineered polynucleotides and lipase polypeptides.

公开(公告)号：US20200339972A1

公开(公告)日：2020-10-29

申请号：US16902001

申请日：2020-06-15

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Vesna Mitchell ,  David Elgart ,  Katrina W. Lexa ,  Nikki Dellas ,  Robert Kevin Orr ,  Oscar Alvizo ,  Ravi David Garcia ,  Judy Victoria Antonio Viduya ,  Courtney Dianne Moffett

IPC: C12N9/84 ,  C07K14/62 ,  C12P21/02

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.

公开(公告)号：US10724025B2

公开(公告)日：2020-07-28

申请号：US15588378

申请日：2017-05-05

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Vesna Mitchell ,  David Elgart ,  Katrina W. Lexa ,  Nikki Dellas ,  Robert Kevin Orr ,  Oscar Alvizo ,  Ravi David Garcia ,  Judy Victoria Antonio Viduya ,  Courtney Dianne Moffett

IPC: C12N9/84 ,  C07K14/62 ,  C12P21/02

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.

公开(公告)号：US11643642B2

公开(公告)日：2023-05-09

申请号：US16616041

申请日：2018-05-23

Applicant: Codexis, Inc.

Inventor： Rama Voladri ,  Christopher Michael Micklitsch ,  Oscar Alvizo ,  Jovana Nazor ,  Da Duan ,  Judy Victoria Antonio Viduya ,  Stephan Jenne ,  Chihui An ,  Keith Allen Canada ,  Paul N. Devine ,  Iman Farasat ,  Anna Fryszkowska ,  Katrina W. Lexa ,  Robert Kevin Orr

IPC: C12N9/84

CPC classification number: C12N9/84 ,  C12Y305/01011

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

公开(公告)号：US20230272363A1

公开(公告)日：2023-08-31

申请号：US18189091

申请日：2023-03-23

Applicant: Codexis, Inc.

Inventor： Rama Voladri ,  Christopher Michael Micklitsch ,  Oscar Alvizo ,  Jovana Nazor ,  Da Duan ,  Judy Victoria Antonio Viduya ,  Stephan Jenne ,  Chihui An ,  Keith Allen Canada ,  Paul N. Devine ,  Iman Farasat ,  Anna Fryszkowska ,  Katrina W. Lexa ,  Robert Kevin Orr

IPC: C12N9/84

CPC classification number: C12N9/84 ,  C12Y305/01011

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

公开(公告)号：US20220356458A1

公开(公告)日：2022-11-10

申请号：US17814371

申请日：2022-07-22

Applicant: Codexis, Inc.

Inventor： William Casey Hallows ,  Kristen Jean Vallieu ,  Nikki Dellas ,  Yu Zhu ,  Judy Victoria Antonio Viduya ,  Chinping Chng ,  Antoinette Sero ,  Gjalt W. Huisman ,  Rachel Cathleen Botham ,  Moulay Hicham Alaoui Ismaili

IPC: C12N9/40 ,  C12N15/52 ,  C12N15/85

Abstract: The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH 7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.

公开(公告)号：US20220154164A1

公开(公告)日：2022-05-19

申请号：US17537941

申请日：2021-11-30

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Vesna Mitchell ,  David Elgart ,  Katrina W. Lexa ,  Nikki Dellas ,  Robert Kevin Orr ,  Oscar Alvizo ,  Ravi David Garcia ,  Judy Victoria Antonio Viduya ,  Courtney Dianne Moffett

IPC: C12N9/84 ,  C07K14/62 ,  C12P21/02

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.

公开(公告)号：US20180320162A1

公开(公告)日：2018-11-08

申请号：US15972919

申请日：2018-05-07

Applicant: Codexis, Inc.

Inventor： Mathew G. Miller ,  Jonathan Vroom ,  Nikki Dellas ,  Donald S. Baskerville ,  Sandy M. Gomes ,  David Elgart ,  Judy Victoria Antonio Viduya

IPC: C12N9/00 ,  C12P19/34 ,  C12Q1/6806

CPC classification number: C12N9/93 ,  C12P19/34 ,  C12Q1/6806 ,  C12Y605/01001

Abstract: The present invention provides engineered ligase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered ligase polypeptides. The invention also provides methods for use of the compositions comprising the engineered ligase polypeptides for diagnostic and other purposes.