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公开(公告)号：US20210238565A1
公开(公告)日：2021-08-05
申请号：US17236928
申请日：2021-04-21
申请人： Codexis, Inc.
发明人： Rama Voladri , David Entwistle , Christopher Michael Micklitsch , Vesna Mitchell , Nikki Dellas , Xiyun Zhang , Antoinette Sero , Brent Dorr , Douglas E. Fuerst
IPC分类号： C12N9/18
摘要： The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.
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公开(公告)号：US20190177707A1
公开(公告)日：2019-06-13
申请号：US16218003
申请日：2018-12-12
申请人： Codexis, Inc.
发明人： Rama Voladri , David Entwistle , Christopher Michael Micklitsch , Vesna Mitchell , Nikki Dellas , Xiyun Zhang , Antoinette Sero , Brent Dorr , Douglas E. Fuerst
IPC分类号： C12N9/18
摘要： The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.
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公开(公告)号：US11015180B2
公开(公告)日：2021-05-25
申请号：US16218003
申请日：2018-12-12
申请人： Codexis, Inc.
发明人： Rama Voladri , David Entwistle , Christopher Michael Micklitsch , Vesna Mitchell , Nikki Dellas , Xiyun Zhang , Antoinette Sero , Brent Dorr , Douglas E. Fuerst
摘要： The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.
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公开(公告)号：US11427813B2
公开(公告)日：2022-08-30
申请号：US16721102
申请日：2019-12-19
申请人： Codexis, Inc.
发明人： William Casey Hallows , Kristen Jean Vallieu , Nikki Dellas , Yu Zhu , Judy Victoria Antonio Viduya , Chinping Chng , Antoinette Sero , Gjalt W. Huisman , Rachel Cathleen Botham , Moulay Hicham Alaoui Ismaili
摘要： The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH 7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
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公开(公告)号：US20210269787A1
公开(公告)日：2021-09-02
申请号：US17186462
申请日：2021-02-26
申请人： Codexis, Inc.
发明人： William Casey Hallows , Nikki Dellas , Yu Zhu , Judy Victoria Antonio Viduya , Chinping Chng , Antoinette Sero , Rachel Cathleen Botham , David William Homan , Moulay Hicham Alaoui Ismaili , Jonathan Vroom , Adam P. Silverman , Kristen Jean Vallieu , Charu Shukla Reddy , Kerryn McCluskie
摘要： The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH 7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
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公开(公告)号：US20220356458A1
公开(公告)日：2022-11-10
申请号：US17814371
申请日：2022-07-22
申请人： Codexis, Inc.
发明人： William Casey Hallows , Kristen Jean Vallieu , Nikki Dellas , Yu Zhu , Judy Victoria Antonio Viduya , Chinping Chng , Antoinette Sero , Gjalt W. Huisman , Rachel Cathleen Botham , Moulay Hicham Alaoui Ismaili
摘要： The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH 7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
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