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公开(公告)号：US20210189365A1
公开(公告)日：2021-06-24
申请号：US17126647
申请日：2020-12-18
申请人： Codexis, Inc.
发明人： William Casey Hallows , Rachel Cathleen Botham , Yu Zhu , Chinping Chng , Nikki Dellas , Gjalt W. Huisman , Moulay Hicham Alaoui Ismaili , David William Homan , Adam P. Silverman , Jonathan Vroom , Jessica P. Lao
IPC分类号： C12N9/34
摘要： The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.
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公开(公告)号：US20220356458A1
公开(公告)日：2022-11-10
申请号：US17814371
申请日：2022-07-22
申请人： Codexis, Inc.
发明人： William Casey Hallows , Kristen Jean Vallieu , Nikki Dellas , Yu Zhu , Judy Victoria Antonio Viduya , Chinping Chng , Antoinette Sero , Gjalt W. Huisman , Rachel Cathleen Botham , Moulay Hicham Alaoui Ismaili
摘要： The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH 7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
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公开(公告)号：US11970722B2
公开(公告)日：2024-04-30
申请号：US17126647
申请日：2020-12-18
申请人： Codexis, Inc.
发明人： William Casey Hallows , Rachel Cathleen Botham , Yu Zhu , Chinping Chng , Nikki Dellas , Gjalt W. Huisman , Moulay Hicham Alaoui Ismaili , David William Homan , Adam P. Silverman , Jonathan Vroom , Jessica P. Lao
CPC分类号： C12N9/2428 , C12Y302/01003 , A61K38/00
摘要： The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.
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公开(公告)号：US20240228997A1
公开(公告)日：2024-07-11
申请号：US18611354
申请日：2024-03-20
申请人： Codexis, Inc.
发明人： William Casey Hallows , Rachel Cathleen Botham , Yu Zhu , Chinping Chng , Nikki Dellas , Gjalt W. Huisman , Moulay Hicham Alaoui Ismaili , David William Homan , Adam P. Silverman , Jonathan Vroom , Jessica P. Lao
CPC分类号： C12N9/2428 , C12Y302/01003 , A61K38/00
摘要： The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.
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公开(公告)号：US11427813B2
公开(公告)日：2022-08-30
申请号：US16721102
申请日：2019-12-19
申请人： Codexis, Inc.
发明人： William Casey Hallows , Kristen Jean Vallieu , Nikki Dellas , Yu Zhu , Judy Victoria Antonio Viduya , Chinping Chng , Antoinette Sero , Gjalt W. Huisman , Rachel Cathleen Botham , Moulay Hicham Alaoui Ismaili
摘要： The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH 7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
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公开(公告)号：US20210269787A1
公开(公告)日：2021-09-02
申请号：US17186462
申请日：2021-02-26
申请人： Codexis, Inc.
发明人： William Casey Hallows , Nikki Dellas , Yu Zhu , Judy Victoria Antonio Viduya , Chinping Chng , Antoinette Sero , Rachel Cathleen Botham , David William Homan , Moulay Hicham Alaoui Ismaili , Jonathan Vroom , Adam P. Silverman , Kristen Jean Vallieu , Charu Shukla Reddy , Kerryn McCluskie
摘要： The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH 7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
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