-
公开(公告)号：US12129494B2
公开(公告)日：2024-10-29
申请号：US17558454
申请日：2021-12-21
申请人： Codexis, Inc.
发明人： Mathew G. Miller , Chinping Chng , Oscar Alvizo , Melissa Ann Mayo , James Nicholas Riggins , Xiang Yi , Jonathan S. Penfield , Gjalt W. Huisman , Jared Davis , Yasushi Saotome
CPC分类号： C12N9/1247 , C12P19/34 , C12Y207/07006 , C12N15/00
摘要： The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.
-
公开(公告)号：US20230257721A1
公开(公告)日：2023-08-17
申请号：US17932420
申请日：2022-09-15
申请人： Codexis, Inc.
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
CPC分类号： C12N9/0006 , C12P7/22 , C12Y101/01184 , Y02E50/10 , C12Y101/01 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
-
公开(公告)号：US11479756B2
公开(公告)日：2022-10-25
申请号：US17149463
申请日：2021-01-14
申请人： Codexis, Inc.
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
-
公开(公告)号：US11421253B2
公开(公告)日：2022-08-23
申请号：US17148834
申请日：2021-01-14
申请人： Codexis, Inc.
摘要： The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity and enhanced acid stability, while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
-
公开(公告)号：US11236311B2
公开(公告)日：2022-02-01
申请号：US16938793
申请日：2020-07-24
申请人： Codexis, Inc.
发明人： Mathew G. Miller , Chinping Chng , Oscar Alvizo , Melissa Ann Mayo , James Nicholas Riggins , Xiang Yi , Jonathan S. Penfield , Gjalt W. Huisman , Jared Davis , Yasushi Saotome
摘要： The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.
-
公开(公告)号：US20210189365A1
公开(公告)日：2021-06-24
申请号：US17126647
申请日：2020-12-18
申请人： Codexis, Inc.
发明人： William Casey Hallows , Rachel Cathleen Botham , Yu Zhu , Chinping Chng , Nikki Dellas , Gjalt W. Huisman , Moulay Hicham Alaoui Ismaili , David William Homan , Adam P. Silverman , Jonathan Vroom , Jessica P. Lao
IPC分类号： C12N9/34
摘要： The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.
-
公开(公告)号：US20210054426A1
公开(公告)日：2021-02-25
申请号：US17080676
申请日：2020-10-26
申请人： Codexis, Inc.
发明人： Jack S Liang , Stephan Jenne , Emily Mundorff , Rama Voladri , James J. Lalonde , Gjalt W. Huisman
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
-
公开(公告)号：US10927351B2
公开(公告)日：2021-02-23
申请号：US16253972
申请日：2019-01-22
申请人： Codexis, Inc.
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
-
公开(公告)号：US10851397B2
公开(公告)日：2020-12-01
申请号：US16457396
申请日：2019-06-28
申请人： Codexis, Inc.
发明人： Jack S Liang , Stephan Jenne , Emily Mundorff , Rama Voladri , James J. Lalonde , Gjalt W. Huisman
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
-
10.发明授权公开(公告)号：US10787689B2
公开(公告)日：2020-09-29
申请号：US16655547
申请日：2019-10-17
申请人： CODEXIS, INC.
发明人： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt W. Huisman , Scott J. Novick , Nicholas J. Agard , Oscar Alvizo , Gregory A. Cope , Wan Lin Yeo , Stefanie Ng Minor
IPC分类号： C12N9/06 , C12P13/02 , C12P13/00 , C12P17/18 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/16
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
-
-
-
-
-
-
-
-
-
搜索结果
160 条记录 (耗时 0.025 秒)
