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公开(公告)号：US20240141304A1
公开(公告)日：2024-05-02
申请号：US18472540
申请日：2023-09-22
申请人： Codexis, Inc.
发明人： Onorato Campopiano , Emily Mundorff , Birthe Borup , Rama Voladri
CPC分类号： C12N9/0006 , C12P17/10 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号：US20230257721A1
公开(公告)日：2023-08-17
申请号：US17932420
申请日：2022-09-15
申请人： Codexis, Inc.
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
CPC分类号： C12N9/0006 , C12P7/22 , C12Y101/01184 , Y02E50/10 , C12Y101/01 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号：US11479756B2
公开(公告)日：2022-10-25
申请号：US17149463
申请日：2021-01-14
申请人： Codexis, Inc.
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号：US11078466B2
公开(公告)日：2021-08-03
申请号：US16790474
申请日：2020-02-13
申请人： CODEXIS, INC.
发明人： Onorato Campopiano , Emily Mundorff , Birthe Borup , Rama Voladri
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号：US20210054426A1
公开(公告)日：2021-02-25
申请号：US17080676
申请日：2020-10-26
申请人： Codexis, Inc.
发明人： Jack S Liang , Stephan Jenne , Emily Mundorff , Rama Voladri , James J. Lalonde , Gjalt W. Huisman
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
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公开(公告)号：US10927351B2
公开(公告)日：2021-02-23
申请号：US16253972
申请日：2019-01-22
申请人： Codexis, Inc.
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号：US10851397B2
公开(公告)日：2020-12-01
申请号：US16457396
申请日：2019-06-28
申请人： Codexis, Inc.
发明人： Jack S Liang , Stephan Jenne , Emily Mundorff , Rama Voladri , James J. Lalonde , Gjalt W. Huisman
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
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公开(公告)号：US20200172880A1
公开(公告)日：2020-06-04
申请号：US16790474
申请日：2020-02-13
申请人： CODEXIS, INC.
发明人： Onorato Campopiano , Emily Mundorff , Birthe Borup , Rama Voladri
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号：US10385371B2
公开(公告)日：2019-08-20
申请号：US15902301
申请日：2018-02-22
申请人： Codexis, Inc.
发明人： Jack S Liang , Stephan Jenne , Emily Mundorff , Rama Voladri , James J. Lalonde , Gjalt W. Huisman
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
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公开(公告)号：US20190071702A1
公开(公告)日：2019-03-07
申请号：US16195227
申请日：2018-11-19
申请人： Codexis, Inc.
摘要： The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
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