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公开(公告)号：US12129495B2
公开(公告)日：2024-10-29
申请号：US18046895
申请日：2022-10-14
申请人： Codexis, Inc.
发明人： Ericka Bermudez , David Elgart , Nikki D. Kruse , Mathew G. Miller , Vesna Mitchell , Jovana Nazor , Nandhitha Subramanian
CPC分类号： C12N9/1252 , C12N15/63 , C12Y207/07007
摘要： The present disclosure relates to engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The present disclosure also provides methods of using the engineered DNA polymerase polypeptides or compositions thereof for diagnostic and other purposes.
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公开(公告)号：US20240263154A1
公开(公告)日：2024-08-08
申请号：US18628461
申请日：2024-04-05
申请人： Codexis, Inc.
发明人： Mathew G. Miller , Vesna Mitchell , Jovana Nazor , Donald S. Baskerville , Nikki Dellas , David Elgart , Jonathan Vroom , Sandy M. Gomes , Nandhitha Subramanian , Ericka Bermudez
IPC分类号： C12N9/12
CPC分类号： C12N9/1252
摘要： The present invention provides engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The invention also provides methods for use of the compositions comprising the engineered DNA polymerase polypeptides for diagnostic and other purposes.
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公开(公告)号：US20210261940A1
公开(公告)日：2021-08-26
申请号：US17316165
申请日：2021-05-10
申请人： Codexis, Inc.
发明人： Scott J. Novick , Xiang Yi , Nikki Dellas , Oscar Alvizo , Jovana Nazor , Da Duan , Vesna Mitchell , Jonathan Vroom , Santhosh Sivaramakrishnan , Nandhitha Subramanian , Jeffrey C. Moore , Mark Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Grant S. Murphy , Nicholas Marshall , Jay Russell , Keith A. Canada
摘要： The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20210238565A1
公开(公告)日：2021-08-05
申请号：US17236928
申请日：2021-04-21
申请人： Codexis, Inc.
发明人： Rama Voladri , David Entwistle , Christopher Michael Micklitsch , Vesna Mitchell , Nikki Dellas , Xiyun Zhang , Antoinette Sero , Brent Dorr , Douglas E. Fuerst
IPC分类号： C12N9/18
摘要： The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.
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公开(公告)号：US20200339972A1
公开(公告)日：2020-10-29
申请号：US16902001
申请日：2020-06-15
申请人： Codexis, Inc.
发明人： Jovana Nazor , Vesna Mitchell , David Elgart , Katrina W. Lexa , Nikki Dellas , Robert Kevin Orr , Oscar Alvizo , Ravi David Garcia , Judy Victoria Antonio Viduya , Courtney Dianne Moffett
摘要： The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
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公开(公告)号：US10745681B2
公开(公告)日：2020-08-18
申请号：US15861849
申请日：2018-01-04
申请人： Codexis, Inc.
发明人： Oscar Alvizo , David Elgart , Robert Kevin Orr , James Nicholas Riggins , Anna Fryszkowska , Katrina W. Lexa , Xiang Yi , Da Duan , Courtney Dianne Moffett , Nikki Dellas , Vesna Mitchell
摘要： The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.
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公开(公告)号：US10724025B2
公开(公告)日：2020-07-28
申请号：US15588378
申请日：2017-05-05
申请人： Codexis, Inc.
发明人： Jovana Nazor , Vesna Mitchell , David Elgart , Katrina W. Lexa , Nikki Dellas , Robert Kevin Orr , Oscar Alvizo , Ravi David Garcia , Judy Victoria Antonio Viduya , Courtney Dianne Moffett
摘要： The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
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公开(公告)号：US10704030B2
公开(公告)日：2020-07-07
申请号：US16562673
申请日：2019-09-06
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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公开(公告)号：US20200010823A1
公开(公告)日：2020-01-09
申请号：US16460062
申请日：2019-07-02
申请人： Codexis, Inc.
发明人： Scott J. Novick , Xiang Yi , Nikki Dellas , Oscar Alvizo , Jovana Nazor , Da Duan , Vesna Mitchell , Jonathan Vroom , Santhosh Sivaramakrishnan , Nandhitha Subramanian , Jeffrey C. Moore , Mark Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Grant Murphy , Nicholas M. Marshall , Jay Russell , Keith A. Canada
摘要： The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20200002685A1
公开(公告)日：2020-01-02
申请号：US16562673
申请日：2019-09-06
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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