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公开(公告)号：US20240026313A1
公开(公告)日：2024-01-25
申请号：US18476753
申请日：2023-09-28
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
CPC分类号： C12N9/0071 , C07K14/80 , C12Y114/14001 , C12P13/001 , C12N9/0042 , C12Y106/02004
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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公开(公告)号：US20200263150A1
公开(公告)日：2020-08-20
申请号：US16652941
申请日：2018-11-02
申请人： Codexis, Inc.
发明人： Jovana Nazor , Jie Yang , Goutami Banerjee , Xiyun Zhang , James Nicholas Riggins , Erika M. Milczek , Jeffrey C. Moore
摘要： The present invention provides engineered transglutamirase enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, methods of producing these enzymes, and methods of using the engineered transglutaminase enzymes.
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公开(公告)号：US10704030B2
公开(公告)日：2020-07-07
申请号：US16562673
申请日：2019-09-06
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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公开(公告)号：US20200002685A1
公开(公告)日：2020-01-02
申请号：US16562673
申请日：2019-09-06
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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公开(公告)号：US10450550B2
公开(公告)日：2019-10-22
申请号：US16152709
申请日：2018-10-05
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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公开(公告)号：US20180201919A1
公开(公告)日：2018-07-19
申请号：US15914258
申请日：2018-03-07
申请人： Codexis, Inc.
发明人： Goutami Banerjee , Jie Yang , Xiyun Zhang , Erika M. Milczek , Melissa Ann Mayo , Stephan Jenne
CPC分类号： C12N9/84 , C12P21/00 , C12Y305/01011
摘要： The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
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公开(公告)号：US20220169994A1
公开(公告)日：2022-06-02
申请号：US17672542
申请日：2022-02-15
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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公开(公告)号：US20210214694A1
公开(公告)日：2021-07-15
申请号：US17203421
申请日：2021-03-16
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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公开(公告)号：US20170275598A1
公开(公告)日：2017-09-28
申请号：US15619176
申请日：2017-06-09
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
IPC分类号： C12N9/02
CPC分类号： C12N9/0071 , C07K14/80 , C12N9/0042 , C12P13/001 , C12Y106/02004 , C12Y114/14001
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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公开(公告)号：US09708587B2
公开(公告)日：2017-07-18
申请号：US14794249
申请日：2015-07-08
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
IPC分类号： C12N9/02
CPC分类号： C12N9/0071 , C12N9/0042 , C12Y106/02004 , C12Y114/14001
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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