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公开(公告)号：US20200010823A1
公开(公告)日：2020-01-09
申请号：US16460062
申请日：2019-07-02
申请人： Codexis, Inc.
发明人： Scott J. Novick , Xiang Yi , Nikki Dellas , Oscar Alvizo , Jovana Nazor , Da Duan , Vesna Mitchell , Jonathan Vroom , Santhosh Sivaramakrishnan , Nandhitha Subramanian , Jeffrey C. Moore , Mark Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Grant Murphy , Nicholas M. Marshall , Jay Russell , Keith A. Canada
摘要： The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US11466259B2
公开(公告)日：2022-10-11
申请号：US16460376
申请日：2019-07-02
申请人： Codexis, Inc.
发明人： Christopher Michael Micklitsch , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , Mikayla Jianghongxia Krawczyk , Margie Tabuga Borra-Garske , Nandhitha Subramanian , Anna Fryszkowska , Nicholas M. Marshall , Agustina Rodriguez-Granillo , Deeptak Verma , Dewan Andrews
摘要： The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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公开(公告)号：US20200010869A1
公开(公告)日：2020-01-09
申请号：US16460376
申请日：2019-07-02
申请人： Codexis, Inc.
发明人： Christopher Michael Micklitsch , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , Mikayla Jianghongxia Krawczyk , Margie Tabuga Borra-Garske , Nandhitha Subramanian , Anna Fryszkowska , Nicholas M. Marshall , Agustina Rodriguez-Granillo , Deeptak Verma , Dewan Andrews
摘要： The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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公开(公告)号：US12110493B2
公开(公告)日：2024-10-08
申请号：US17490215
申请日：2021-09-30
申请人： Codexis, Inc.
发明人： Scott J. Novick , Nikki Dellas , Vesna Mitchell , Da Duan , Jovana Nazor , Oscar Alvizo , Auric Anthony Sowell-Kantz , Jeffrey C. Moore , Mark A. Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Nicholas M. Marshall , Jay H. Russell , Keith A. Canada
IPC分类号： C12N15/63
CPC分类号： C12N15/63 , C12Y204/02001
摘要： The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20240287474A1
公开(公告)日：2024-08-29
申请号：US18657101
申请日：2024-05-07
申请人： Codexis, Inc.
发明人： Christopher Micklitsch , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , Mikayla Jianghongxia Krawczyk , Margie Tabuga Borra-Garske , Nandhitha Subramanian , Anna Fryszkowska , Nicholas M. Marshall , Agustina Rodriguez-Granillo , Deeptak Verma , Dewan Andrews
CPC分类号： C12N9/0006 , C12N15/52 , C12N9/001 , C12P21/02 , C12Y101/03009
摘要： The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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公开(公告)号：US20220010316A1
公开(公告)日：2022-01-13
申请号：US17490215
申请日：2021-09-30
申请人： Codexis, Inc.
发明人： Scott J. Novick , Nikki Dellas , Vesna Mitchell , Da Duan , Jovana Nazor , Oscar Alvizo , Auric Anthony Sowell-Kantz , Jeffrey C. Moore , Mark A. Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Nicholas M. Marshall , Jay H. Russell , Keith A. Canada
IPC分类号： C12N15/63
摘要： The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US11034948B2
公开(公告)日：2021-06-15
申请号：US16460062
申请日：2019-07-02
申请人： Codexis, Inc.
发明人： Scott J. Novick , Xiang Yi , Nikki Dellas , Oscar Alvizo , Jovana Nazor , Da Duan , Vesna Mitchell , Jonathan Vroom , Santhosh Sivaramakrishnan , Nandhitha Subramanian , Jeffrey C. Moore , Mark Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Grant Murphy , Nicholas M. Marshall , Jay Russell , Keith A. Canada
摘要： The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20200010834A1
公开(公告)日：2020-01-09
申请号：US16460025
申请日：2019-07-02
申请人： Codexis, Inc.
发明人： Scott J. Novick , Nikki Dellas , Vesna Mitchell , Da Duan , Jovana Nazor , Oscar Alvizo , Auric Anthony Sowell-Kantz , Jeffrey C. Moore , Mark Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Nicholas M. Marshall , Jay Russell , Keith A. Canada
IPC分类号： C12N15/63
摘要： The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US12012618B2
公开(公告)日：2024-06-18
申请号：US17931003
申请日：2022-09-09
申请人： Codexis, Inc.
发明人： Christopher Michael Micklitsch , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , Mikayla Jianghongxia Krawczyk , Margie Tabuga Borra-Garske , Nandhitha Subramanian , Anna Fryszkowska , Nicholas M. Marshall , Agustina Rodriguez-Granillo , Deeptak Verma , Dewan Andrews
CPC分类号： C12N9/0006 , C12N15/52 , C12N9/001 , C12P21/02 , C12Y101/03009
摘要： The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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公开(公告)号：US20230026007A1
公开(公告)日：2023-01-26
申请号：US17931003
申请日：2022-09-09
申请人： Codexis, Inc.
发明人： Christopher Michael Micklitsch , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , Mikayla Jianghongxia Krawczyk , Margie Tabuga Borra-Garske , Nandhitha Subramanian , Anna Fryszkowska , Nicholas M. Marshall , Agustina Rodriguez-Granillo , Deeptak Verma , Dewan Andrews
摘要： The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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