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公开(公告)号：US20220162580A1
公开(公告)日：2022-05-26
申请号：US17592869
申请日：2022-02-04
申请人： Codexis, Inc.
发明人： Da Duan , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , James Nicholas Riggins , Jonathan Vroom , Santhosh Sivaramakrishnan , Hao Yang , Anna Fryszkowska , Mark A. Huffman , Joshua N. Kolev , Iman Farasat , Agustina Rodriguez-Granillo , Deeptak Verma
IPC分类号： C12N9/88
摘要： The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.
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公开(公告)号：US20230272363A1
公开(公告)日：2023-08-31
申请号：US18189091
申请日：2023-03-23
申请人： Codexis, Inc.
发明人： Rama Voladri , Christopher Michael Micklitsch , Oscar Alvizo , Jovana Nazor , Da Duan , Judy Victoria Antonio Viduya , Stephan Jenne , Chihui An , Keith Allen Canada , Paul N. Devine , Iman Farasat , Anna Fryszkowska , Katrina W. Lexa , Robert Kevin Orr
IPC分类号： C12N9/84
CPC分类号： C12N9/84 , C12Y305/01011
摘要： The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.
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公开(公告)号：US20210254119A1
公开(公告)日：2021-08-19
申请号：US17239953
申请日：2021-04-26
申请人： Codexis, Inc.
发明人： Jeffrey C. Moore , Jack Liang , Jonathan Penfield , Jovana Nazor , Nikki Dellas , Vesna Mitchell , Da Duan , Iman Farasat , Agustina Rodriguez-Granillo , Grant Murphy , Nicholas Marshall
摘要： The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.
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公开(公告)号：US20200010868A1
公开(公告)日：2020-01-09
申请号：US16460118
申请日：2019-07-02
申请人： Codexis, Inc.
发明人： Da Duan , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , James Nicholas Riggins , Jonathan Vroom , Santhosh Sivaramakrishnan , Hao Yang , Anna Fryszkowska , Mark Huffman , Joshua Kolev , Iman Farasat , Agustina Rodriguez-Granillo , Deeptak Verma
摘要： The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.
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公开(公告)号：US20240068005A1
公开(公告)日：2024-02-29
申请号：US18352899
申请日：2023-07-14
申请人： Codexis, Inc.
发明人： Jeffrey C. Moore , Jack Liang , Jonathan Penfield , Jovana Nazor , Nikki Dellas , Vesna Mitchell , Da Duan , Iman Farasat , Agustina Rodriguez-Granillo , Grant Murphy , Nicholas Marshall
CPC分类号： C12P41/002 , C12N9/0004 , C12N9/0006 , C12N15/70 , C12Y101/01002 , C12Y120/01001
摘要： The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.
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公开(公告)号：US11274286B2
公开(公告)日：2022-03-15
申请号：US16460118
申请日：2019-07-02
申请人： Codexis, Inc.
发明人： Da Duan , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , James Nicholas Riggins , Jonathan Vroom , Santhosh Sivaramakrishnan , Hao Yang , Anna Fryszkowska , Mark A. Huffman , Joshua N. Kolev , Iman Farasat , Agustina Rodriguez-Granillo , Deeptak Verma
摘要： The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.
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公开(公告)号：US11021729B2
公开(公告)日：2021-06-01
申请号：US16605576
申请日：2018-04-13
申请人： Codexis, Inc.
发明人： Jeffrey C. Moore , Jack Liang , Jonathan Penfield , Jovana Nazor , Nikki Dellas , Vesna Mitchell , Da Duan , Iman Farasat , Agustina Rodriguez-Granillo , Grant Murphy , Nicholas Marshall
摘要： The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.
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公开(公告)号：US20240076647A1
公开(公告)日：2024-03-07
申请号：US18503542
申请日：2023-11-07
申请人： Codexis, Inc.
发明人： Da Duan , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , James Nicholas Riggins , Jonathan Vroom , Santhosh Sivaramakrishnan , Hao Yang , Anna Fryszkowska , Mark A. Huffman , Joshua N. Kolev , Iman Farasat , Agustina Rodriguez-Granillo , Deeptak Verma
IPC分类号： C12N9/88
摘要： The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.
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公开(公告)号：US11845968B2
公开(公告)日：2023-12-19
申请号：US17592869
申请日：2022-02-04
申请人： Codexis, Inc.
发明人： Da Duan , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , James Nicholas Riggins , Jonathan Vroom , Santhosh Sivaramakrishnan , Hao Yang , Anna Fryszkowska , Mark A. Huffman , Joshua N. Kolev , Iman Farasat , Agustina Rodriguez-Granillo , Deeptak Verma
CPC分类号： C12N9/88 , C12N15/63 , C12P21/02 , C12Y401/02004
摘要： The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.
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公开(公告)号：US11746369B2
公开(公告)日：2023-09-05
申请号：US17239953
申请日：2021-04-26
申请人： Codexis, Inc.
发明人： Jeffrey C. Moore , Jack Liang , Jonathan Penfield , Jovana Nazor , Nikki Dellas , Vesna Mitchell , Da Duan , Iman Farasat , Agustina Rodriguez-Granillo , Grant Murphy , Nicholas Marshall
CPC分类号： C12P41/002 , C12N9/0004 , C12N9/0006 , C12N15/70 , C12Y101/01002 , C12Y120/01001
摘要： The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.
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