公开(公告)号：US4259114A

公开(公告)日：1981-03-31

申请号：US108355

申请日：1979-12-31

申请人： Carl M. Berke ,  Barbara A. Baughman

发明人： Carl M. Berke ,  Barbara A. Baughman

IPC分类号： G03C8/28 ,  C23C3/02

CPC分类号： G03C8/28

摘要： Noble metal silver-precipitating nuclei are prepared by reducing a noble metal salt or complex in the presence of a first polymer with a Sn.degree. colloid formed by the non-aqueous borohydride reduction of a tin salt in the presence of an organic solvent for the tin salt and a nitrogen-containing metal chelating polymer. The invention is also directed to film units employing said nuclei.

摘要翻译： 贵金属银沉淀核是通过在第一种聚合物存在下还原贵金属盐或络合物的方式制备的，所述金属盐或络合物在锡的有机溶剂存在下，通过锡盐的非硼氢化钠还原形成的Sn？胶体 盐和含氮金属螯合聚合物。 本发明还涉及使用所述核的胶片单元。

公开(公告)号：US4281056A

公开(公告)日：1981-07-28

申请号：US80691

申请日：1979-10-01

申请人： Carl M. Berke

发明人： Carl M. Berke

IPC分类号： G03C8/28 ,  G03C1/48 ,  F01C21/16 ,  F03C3/00 ,  G03C5/54

CPC分类号： G03C8/28

摘要： Silver-precipitating nuclei are prepared by partially oxidizing a stannous salt reducing agent with a ferric oxidizing agent and then reducing a noble metal salt or complex with said reducing agent.

摘要翻译： 通过用三价铁氧化剂部分氧化亚锡盐还原剂然后还原所述还原剂的贵金属盐或络合物来制备银沉淀核。

公开(公告)号：US5100621A

公开(公告)日：1992-03-31

申请号：US246734

申请日：1988-09-20

申请人： Carl M. Berke ,  Thomas L. Collins ,  David P. Leja ,  Ronald W. Mink

发明人： Carl M. Berke ,  Thomas L. Collins ,  David P. Leja ,  Ronald W. Mink

IPC分类号： B01L3/00 ,  B01L99/00 ,  G01N1/00 ,  G09B23/28

CPC分类号： B01L99/00 ,  B01L3/00 ,  G09B23/28 ,  G01N2001/007 ,  Y10S435/81 ,  Y10S436/808

摘要： A test kit for performing a diagnostic procedure. The kit comprises a plastic base which has an upper surface. The base is formed from a plastic material and a plurality of upwardly opening nests are provided in the upper surface of the base. A test component is provided in each of the nests in a manner such that the components may be displayed and made available for use. The test components are preferably displayed in essentially the plane of the upper surface of the base and an instruction booklet is provided so as to overlie the test components at the beginning of the procedure. The arrangement of the components and the size and shape of the pages of the booklet are such that as the user follows the instructions and turns pages in the booklet, components remain hidden from view until needed in conducting the procedure. The pages of the booklet are progressively shorter from front to back in the booklet so that as the pages are turned components of the kit come into view as needed.

摘要翻译： 用于执行诊断程序的测试工具包。 该套件包括具有上表面的塑料基座。 基部由塑料材料形成，并且在基部的上表面设置有多个向上开口的巢。 在每个巢中提供测试组件，使得可以显示组件并使其可供使用。 测试部件优选地显示在基座的上表面的基本上平面中，并且提供了说明书，以便在操作开始时覆盖测试部件。 组件的布置以及小册子的页面的大小和形状使得当用户遵循指令并转动小册子中的页面时，组件保持隐藏，直到进行该过程为止。 小册子的页面从小册子的前后逐渐缩小，以便随着页面的转换，套件的组件可以根据需要进行查看。

公开(公告)号：US5084245A

公开(公告)日：1992-01-28

申请号：US630432

申请日：1990-12-20

申请人： Carl M. Berke ,  Donald J. Lennon ,  Paul B. Foster ,  Gary W. Boys

发明人： Carl M. Berke ,  Donald J. Lennon ,  Paul B. Foster ,  Gary W. Boys

IPC分类号： B01L3/00 ,  G01N33/53 ,  G01N33/543

CPC分类号： B01L3/502 ,  G01N33/5302 ,  G01N33/54366 ,  Y10S435/81 ,  Y10S436/808 ,  Y10S436/81

摘要： A disposable, pre-packaged device as particularly suitable for conducting diagnostic procedures based on immunological reactions using specimens gathered up in the absorbent tip of a swab. The device is made up of a base component upon which a sample sensitive element is mounted and a guide member that is normally mounted on the base component in covering relationship to the reactive element. The guide member includes structure which defines an elongated passageway extending therethrough. One end of the passageway is positioned in close proximity to the sensitive element when the member is mounted on the base component. The other end of the passageway opens outwardly of the guide member. In using the device, the swab tip is pushed through the passageway and toward the sensitive element using the stick of the swab. A number of ribs are positioned in the passageway adjacent the sensitive element to squeeze the tip and express fluid therefrom as the tip is pushed toward the sensitive element. Thus, the liquid in the swab tip is expressed therefrom and brought into intimate contact with the sensitive element. The results of the test are visually observable by removing the guide member from the base component to uncover the sensitive element.

摘要翻译： 一种一次性的预先包装的装置，特别适用于使用收集在拭子的吸收尖端中的样本进行基于免疫反应的诊断程序。 该装置由安装有样品敏感元件的基础部件和通常安装在基部部件上的与反应元件覆盖关系的引导部件组成。 引导构件包括限定延伸穿过其中的细长通道的结构。 当构件安装在基座部件上时，通道的一端位于紧邻敏感元件的位置。 通道的另一端通向导向件的外部。 在使用该装置时，拭子尖被推动通过通道并且使用拭子的棒朝向敏感元件。 多个肋条定位在靠近敏感元件的通道中，以挤压尖端并且当尖端被推向敏感元件时从其表达流体。 因此，拭子尖端中的液体由其表示并与敏感元件紧密接触。 通过从基部组件移除引导构件以露出敏感元件，目视观察测试结果。

公开(公告)号：US4440541A

公开(公告)日：1984-04-03

申请号：US380054

申请日：1982-05-20

申请人： Carl M. Berke

发明人： Carl M. Berke

IPC分类号： G02B1/04 ,  G02B5/30 ,  D06P7/00

CPC分类号： G02B5/3033 ,  G02B1/04

摘要： A dichroic light polarizer comprising a sheet of molecularly oriented polyacrylic acid/chitosan complex having incorporated therein a dichroic dye.

摘要翻译： 一种二向色光偏振器，包括分子取向的聚丙烯酸/壳聚糖复合物片，其中掺入二色染料。

公开(公告)号：US4851337A

公开(公告)日：1989-07-25

申请号：US894566

申请日：1986-08-08

申请人： Carl M. Berke

发明人： Carl M. Berke

IPC分类号： G01N33/545 ,  C12Q1/14 ,  C12Q1/24 ,  G01N33/531 ,  G01N33/569

CPC分类号： C12Q1/14 ,  C12Q1/24 ,  G01N33/56944 ,  G01N2333/315 ,  G01N2400/10 ,  Y10S435/81 ,  Y10S435/82 ,  Y10S435/885

摘要： A vessel containing a polymeric acid is used in a method and test kit for extracting a bacterial (e.g., streptococcal) antigen from a test sample, for example, preliminary to an immunoassay. To extract the antigen from bacteria in the sample, a precursor reagent is applied to the vessel acid and incubated with the sample. The kit includes a vial containing the acid and another vial containing the precursor. The kit is produced by including the acid polymer in the vial or vessel, e.g., as a pellet or coating.

摘要翻译： 含有聚合酸的容器用于从测试样品中提取细菌（例如，链球菌）抗原的方法和测试试剂盒，例如预先进行免疫测定。 为了从样品中的细菌中提取抗原，将前体试剂施加到容器酸上并与样品一起温育。 该试剂盒包括含有酸的小瓶和另一个含有前体的小瓶。 该试剂盒通过将酸聚合物包括在小瓶或容器中，例如作为颗粒或涂层来制备。

公开(公告)号：US4501835A

公开(公告)日：1985-02-26

申请号：US549833

申请日：1983-11-09

申请人： Carl M. Berke

发明人： Carl M. Berke

IPC分类号： B01D71/80 ,  C08B37/08 ,  C08L5/08 ,  B01D13/00

CPC分类号： C08B37/003 ,  B01D71/80 ,  C08L5/08

摘要： A novel composition of matter comprising a polyacrylic acid/chitosan complex. This complex is particularly useful as a membrane or filter.

摘要翻译： 包含聚丙烯酸/壳聚糖复合物的新型物质组合物。 该复合物作为膜或过滤器特别有用。

公开(公告)号：US4459358A

公开(公告)日：1984-07-10

申请号：US454141

申请日：1982-12-29

申请人： Carl M. Berke

发明人： Carl M. Berke

IPC分类号： G01N31/22 ,  G01N33/543 ,  G01N33/52 ,  G01N33/54 ,  G01N33/58

CPC分类号： G01N33/54386 ,  G01N31/22 ,  Y10S435/805 ,  Y10S436/81

摘要： A multilayer element for the analysis of a liquid containing an analyte comprising a reaction layer which retains a predetermined amount of a diffusible reagent containing a detectable species; said reagent adapted to be rendered substantially non-diffusible by said analyte as a function of the concentration of said analyte; a registration layer adapted to receive reagent diffusing thereto; means for detecting said reagent in said registration layer and an insulating layer intermediate said reaction layer adapted to provide discrimination between detectable species in said reagent layer and said registration layer.

摘要翻译： 用于分析含有分析物的液体的多层元件，所述分析物包含保留预定量的含有可检测物质的扩散剂的反应层; 所述试剂适于被所述分析物基本上不可扩散，作为所述分析物的浓度的函数; 适于接收向其扩散的试剂的配准层; 用于检测所述配准层中的所述试剂的装置和适于提供所述试剂层中的可检测物质与所述配准层之间的区别的所述反应层之间的绝缘层。