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公开(公告)号：US10266684B2
公开(公告)日：2019-04-23
申请号：US16025255
申请日：2018-07-02
Inventor： Susan P. James , Hieu Bui
IPC: A61L27/48 , A61F2/24 , A61L27/18 , A61L27/20 , A61L27/54 , A61L27/16 , C08L23/06 , C08K5/205 , C08K3/011
Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.
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公开(公告)号：US10071186B2
公开(公告)日：2018-09-11
申请号：US14381332
申请日：2013-03-11
Inventor： Susan P. James , Harold Dean, IV , Lakshmi Prasad Dasi , Marcio H. Forleo , Ketul C. Popat , Nicole R. Lewis , David Alois Prawel
IPC: A61L27/48 , A61F2/24 , A61L27/18 , A61L27/20 , A61L27/54 , A61L27/16 , A61L27/50 , A61L29/12 , A61L29/14 , A61L31/12 , A61L31/14 , A61L17/10
Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), and polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.
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公开(公告)号：US10435523B2
公开(公告)日：2019-10-08
申请号：US15388355
申请日：2016-12-22
Inventor： Susan P. James , Min Zhang , Guy Beauregard , Rachael Kurkowski Oldinski
Abstract: The present disclosure provides, inter alia, a method of producing an outer layer material for forming into a structure and that comprises an entanglement having a hydrophobic polymer host and a hydrophilic guest, including in one embodiment the steps of: intermingling cloaked hydrophilic guest complexes with the hydrophobic host; crosslinking molecules of the guest with the guest; and performing a hydrolysis reaction.
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公开(公告)号：US10167387B2
公开(公告)日：2019-01-01
申请号：US14917795
申请日：2014-09-10
Inventor： Susan P. James , Travis S. Bailey , Ketul C. Popat , David A. Prawel , Jackson T. Lewis , Richard L. Koch
Abstract: Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.
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5.发明申请Glycosaminoglycan and Synthetic Polymer Material for Blood-Contacting Applications 审中-公开用于血液接触应用的糖胺聚糖和合成聚合物材料公开(公告)号：US20150196688A1
公开(公告)日：2015-07-16
申请号：US14381332
申请日：2013-03-11
Inventor： Susan P. James , Harold Dean, IV , Lakshmi Prasad Dasi , Marcio H. Forleo , Ketul C. Popat , Nicole R. Lewis , David Alois Prawel
CPC classification number: A61L27/48 , A61F2/24 , A61L17/10 , A61L27/16 , A61L27/18 , A61L27/20 , A61L27/50 , A61L27/54 , A61L29/126 , A61L29/14 , A61L31/129 , A61L31/14 , A61L2300/236 , A61L2300/42 , A61L2300/62 , A61L2430/20 , C08L5/08
Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), and polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.
Abstract translation: 本文提供的复合材料包括：选自低密度聚乙烯（LDPE），线性低密度聚乙烯（LLDPE），聚对苯二甲酸乙二醇酯（PET），聚四氟乙烯（PTFE）和聚丙烯（PP） ，聚氨酯，聚己内酯（PCL），聚二甲基硅氧烷（PDMS），聚甲基丙烯酸甲酯（PMMA）和聚甲醛（POM）; 和包含透明质酸的客体分子; 其中所述客体分子设置在所述聚合物主体内，并且其中所述客体分子共价键合至至少一个其它客体分子。 还提供了用于形成复合材料的方法和由复合材料制成的收缩装置，例如心脏瓣膜和血管移植物。
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Patent Agency Ranking
公开(公告)号：US20180305528A1
公开(公告)日：2018-10-25
申请号：US16025255
申请日：2018-07-02
Inventor： Susan P. James , Hieu Bui
CPC classification number: C08L23/06 , C08K3/011 , C08K5/205 , C08L2207/066 , C08L2312/00
Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.
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7.发明授权Outer layer having entanglement of hydrophobic polymer host and hydrophilic polymer guest 有权外层具有疏水聚合物主体和亲水聚合物客体的缠结公开(公告)号：US09567447B2
公开(公告)日：2017-02-14
申请号：US14013856
申请日：2013-08-29
Inventor： Susan P. James , Min Zhang , Guy Beauregard
IPC: C07H5/04 , C07H1/00 , C08J9/42 , C08B37/00 , C08B37/08 , C08L5/08 , C08L101/00 , B05D5/00 , B29C67/24
CPC classification number: C08J9/42 , B05D5/00 , B29C67/24 , C08B37/00 , C08B37/0072 , C08L5/08 , C08L101/00 , Y10T428/249953 , Y10T428/31504 , Y10T428/31855 , Y10T428/31971 , C08L2666/02 , C08L2666/26
Abstract: An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer.
Abstract translation: 具有缠结的外层，其包含掩蔽的亲水客体和疏水性聚合物主体的混合物，其中客体的分子彼此交联。 在某些情况下，使用客人的复合物可能是理想的或甚至是必需的。 客人和主持人的混合包括物理缠结，无论其是否还包括通过其间的初次键合（例如，化学/共价键合）的交联。 还有一种制造具有这种缠结的外层的方法，包括以下步骤：暂时隐藏客人的至少一部分亲水基团; 通过将具有掩蔽基团的客体扩散到结构的孔的至少一部分中来将具有多孔聚合物结构的至少一部分掩蔽组混合; 在孔内，与客体交联客体的至少一部分分子; 并去除隐形。 掩蔽可以通过甲硅烷基化或酰化进行。 混合可以通过生产客体和主机的混合物（无论是溶液，粉末，颗粒等）形式进行; 接下来，进行客人与其自身的交联; 然后将混合物模塑成外层。
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8.发明授权Outer layer having entanglement of hydrophobic polymer host blended with a maleated hydrophobic polymer co-host, and hydrophilic polymer guest 有权疏水聚合物主体与马来化疏水性聚合物共主体共混的外层和亲水性聚合物客体的外层公开(公告)号：US09533077B2
公开(公告)日：2017-01-03
申请号：US14013360
申请日：2013-08-29
Inventor： Susan P. James , Min Zhang , Guy Beauregard , Rachael Kurkowski Oldinski
CPC classification number: C08J3/246 , A61L31/048 , C08B37/00 , C08B37/0072 , C08J9/42 , C08J2323/06 , C08J2405/08 , C08L5/08 , Y10T428/249953 , C08L2666/02 , C08L101/00 , C08L2666/26
Abstract: The present disclosure provides, inter alia, a method of producing an outer layer material for forming into a structure and that comprises an entanglement having a hydrophobic polymer host and a hydrophilic guest, including in one embodiment the steps of: intermingling cloaked hydrophilic guest complexes with the hydrophobic host; crosslinking molecules of the guest with the guest; and performing a hydrolysis reaction.
Abstract translation: 本公开尤其提供了一种制备用于形成结构的外层材料的方法，其包括具有疏水性聚合物主体和亲水性客体的缠结，其包括在一个实施方案中为以下步骤：将掩蔽的亲水性客体络合物与 疏水性宿主; 客人与客人交流分子; 并进行水解反应。
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公开(公告)号：US20190119485A1
公开(公告)日：2019-04-25
申请号：US16183333
申请日：2018-11-07
Inventor： Susan P. James , David A. Prawel , Richard L. Koch
Abstract: Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.
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10.发明授权公开(公告)号：US10265440B2
公开(公告)日：2019-04-23
申请号：US15467756
申请日：2017-03-23
Inventor： Susan P. James , Susan S. Yonemura , Ariane Vartanian
IPC: A61L27/52 , C08G81/02 , A61L27/20 , A61L27/18 , A61K47/36 , A61L15/60 , A61K31/726 , A61K31/727 , A61K31/728 , A61K31/737 , C08J3/075 , C08F251/00 , C08L51/02 , A61K9/00 , A61K9/06 , A61K47/32
Abstract: The present invention relates to polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer. The present invention also relates to hydrogels containing the polymeric materials. The present invention further relates to methods of synthesizing the polymeric materials and hydrogels of the present invention.
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