公开(公告)号：US20180305528A1

公开(公告)日：2018-10-25

申请号：US16025255

申请日：2018-07-02

Applicant: Colorado State University Research Foundation

Inventor： Susan P. James ,  Hieu Bui

IPC: C08L23/06 ,  C08K5/205 ,  C08K3/011

CPC classification number: C08L23/06 ,  C08K3/011 ,  C08K5/205 ,  C08L2207/066 ,  C08L2312/00

Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.

公开(公告)号：US20220133474A1

公开(公告)日：2022-05-05

申请号：US17648076

申请日：2022-01-14

Applicant: Ohio State Innovation Foundation ,  Georgia Institute of Technology ,  Colorado State University Research Foundation

Inventor： Hieu Bui ,  Lakshmi Prasad Dasi ,  Megan Heitkemper ,  Susan James ,  Nipa Khair

IPC: A61F2/24

Abstract: A transcatheter prosthetic heart valve includes a stent frame and a leaflet material. The stent frame includes a top portion and a bottom portion. The leaflet material includes a lower portion attached to the stent frame and an upper portion that includes leaflets capable of moving between an open configuration and a closed configuration. At least a portion of the leaflet material weaves through the stent frame. The transcatheter prosthetic heart valve also includes one or more reinforcement components coupled to the stent frame and/or to the leaflet material to enhance performance of the transcatheter heart valve.

公开(公告)号：US10266684B2

公开(公告)日：2019-04-23

申请号：US16025255

申请日：2018-07-02

Applicant: Colorado State University Research Foundation

Inventor： Susan P. James ,  Hieu Bui

IPC: A61L27/48 ,  A61F2/24 ,  A61L27/18 ,  A61L27/20 ,  A61L27/54 ,  A61L27/16 ,  C08L23/06 ,  C08K5/205 ,  C08K3/011

Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.