公开(公告)号：US20160222203A1

公开(公告)日：2016-08-04

申请号：US14917795

申请日：2014-09-10

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Susan P. James ,  Travis S. Bailey ,  Ketul C. Popat ,  David A. Prawel ,  Jackson T. Lewis ,  Richard L. Koch

IPC: C08L43/04 ,  G02C7/04 ,  A61F2/16 ,  G02B1/04 ,  A61L27/48

CPC classification number: C08L43/04 ,  A61F2/16 ,  A61F2002/1681 ,  A61L27/48 ,  C08G77/388 ,  G02B1/043 ,  G02C7/049

Abstract: Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.

Abstract translation: 本文提供了包含聚合物主体的聚合物材料; 和包含糖胺聚糖的客体分子; 其中所述客体分子设置在所述聚合物主体内，并且其中所述客体分子共价键合至至少一个其它客体分子。 在一些实施方案中，聚合物主体包含硅氧烷基聚合物。 在其它实施方案中，糖胺聚糖选自透明质酸及其衍生物。

公开(公告)号：US20190031835A1

公开(公告)日：2019-01-31

申请号：US15539312

申请日：2016-12-05

Applicant: Colorado State University Research Foundation ,  The Regents of the University of Colorado, a Body Corporate

Inventor： Travis S. Bailey ,  Chen Guo ,  Jackson T. Lewis ,  Kristine Fischenich ,  Tammy Haut Donahue ,  Dilanji Wijayasekara ,  Matthew G. Cowan ,  Douglas L. Gin ,  Richard D. Noble

IPC: C08J3/075 ,  B01D71/80 ,  B01J13/00 ,  C08L53/00 ,  H01M2/16 ,  B01D69/02

Abstract: Provided herein is a block copolymer hydrogel, comprising a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO—SOS by weight. The block copolymer hydrogel has a fatigue resistance to at least 500,000 compression cycles. Also provided are methods for forming the hydrogel.

公开(公告)号：US10428185B2

公开(公告)日：2019-10-01

申请号：US15539312

申请日：2016-12-05

Applicant: Colorado State University Research Foundation ,  The Regents of the University of Colorado, a Body Corporate

Inventor： Travis S. Bailey ,  Chen Guo ,  Jackson T. Lewis ,  Kristine Fischenich ,  Tammy Haut Donahue ,  Dilanji Wijayasekara ,  Matthew G. Cowan ,  Douglas L. Gin ,  Richard D. Noble

IPC: C08J3/075 ,  B01D69/02 ,  B01D71/80 ,  B01J13/00 ,  C08L53/00 ,  H01M2/16 ,  B01D71/76 ,  B01D71/28 ,  B01D71/52

Abstract: Provided herein is a block copolymer hydrogel, comprising a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO—SOS by weight. The block copolymer hydrogel has a fatigue resistance to at least 500,000 compression cycles. Also provided are methods for forming the hydrogel.

公开(公告)号：US10532130B2

公开(公告)日：2020-01-14

申请号：US15539475

申请日：2016-12-05

Applicant: Colorado State University Research Foundation

Inventor： Travis S. Bailey ,  Kristine Fischenich ,  Jackson T. Lewis ,  Tammy Haut Donahue ,  Chen Guo

IPC: C08J3/075 ,  A61L27/52 ,  B01D69/02 ,  B01D71/80 ,  B01J13/00 ,  C08L53/00 ,  H01M2/16 ,  A61L27/26 ,  C08G81/02

Abstract: Provided herein is a soft tissue mimetic formed from a block copolymer hydrogel and methods of making such. The hydrogel comprises a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO-SOS by weight. The soft tissue mimetic has a fatigue resistance to at least 500,000 compression cycles.

公开(公告)号：US20190151511A1

公开(公告)日：2019-05-23

申请号：US15539475

申请日：2016-12-05

Applicant: Colorado State University Research Foundation

Inventor： Travis S. Bailey ,  Kristine Fischenich ,  Jackson T. Lewis ,  Tammy Haut Donahue ,  Chen Guo

IPC: A61L27/52 ,  C08J3/075 ,  A61L27/26 ,  C08L53/00 ,  C08G81/02

Abstract: Provided herein is a soft tissue mimetic formed from a block copolymer hydrogel and methods of making such. The hydrogel comprises a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO-SOS by weight. The soft tissue mimetic has a fatigue resistance to at least 500,000 compression cycles.

公开(公告)号：US10167387B2

公开(公告)日：2019-01-01

申请号：US14917795

申请日：2014-09-10

Applicant: Colorado State University Research Foundation

Inventor： Susan P. James ,  Travis S. Bailey ,  Ketul C. Popat ,  David A. Prawel ,  Jackson T. Lewis ,  Richard L. Koch

IPC: A61F2/16 ,  A61L27/44 ,  A61L27/48 ,  C08G77/388 ,  C08G77/14 ,  C08L43/04 ,  G02B1/04 ,  G02C7/04

Abstract: Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.