公开(公告)号：US20190031835A1

公开(公告)日：2019-01-31

申请号：US15539312

申请日：2016-12-05

Applicant: Colorado State University Research Foundation ,  The Regents of the University of Colorado, a Body Corporate

Inventor： Travis S. Bailey ,  Chen Guo ,  Jackson T. Lewis ,  Kristine Fischenich ,  Tammy Haut Donahue ,  Dilanji Wijayasekara ,  Matthew G. Cowan ,  Douglas L. Gin ,  Richard D. Noble

IPC: C08J3/075 ,  B01D71/80 ,  B01J13/00 ,  C08L53/00 ,  H01M2/16 ,  B01D69/02

Abstract: Provided herein is a block copolymer hydrogel, comprising a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO—SOS by weight. The block copolymer hydrogel has a fatigue resistance to at least 500,000 compression cycles. Also provided are methods for forming the hydrogel.

公开(公告)号：US10428185B2

公开(公告)日：2019-10-01

申请号：US15539312

申请日：2016-12-05

Applicant: Colorado State University Research Foundation ,  The Regents of the University of Colorado, a Body Corporate

Inventor： Travis S. Bailey ,  Chen Guo ,  Jackson T. Lewis ,  Kristine Fischenich ,  Tammy Haut Donahue ,  Dilanji Wijayasekara ,  Matthew G. Cowan ,  Douglas L. Gin ,  Richard D. Noble

IPC: C08J3/075 ,  B01D69/02 ,  B01D71/80 ,  B01J13/00 ,  C08L53/00 ,  H01M2/16 ,  B01D71/76 ,  B01D71/28 ,  B01D71/52

Abstract: Provided herein is a block copolymer hydrogel, comprising a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO—SOS by weight. The block copolymer hydrogel has a fatigue resistance to at least 500,000 compression cycles. Also provided are methods for forming the hydrogel.

公开(公告)号：US10532130B2

公开(公告)日：2020-01-14

申请号：US15539475

申请日：2016-12-05

Applicant: Colorado State University Research Foundation

Inventor： Travis S. Bailey ,  Kristine Fischenich ,  Jackson T. Lewis ,  Tammy Haut Donahue ,  Chen Guo

IPC: C08J3/075 ,  A61L27/52 ,  B01D69/02 ,  B01D71/80 ,  B01J13/00 ,  C08L53/00 ,  H01M2/16 ,  A61L27/26 ,  C08G81/02

Abstract: Provided herein is a soft tissue mimetic formed from a block copolymer hydrogel and methods of making such. The hydrogel comprises a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO-SOS by weight. The soft tissue mimetic has a fatigue resistance to at least 500,000 compression cycles.

公开(公告)号：US20190151511A1

公开(公告)日：2019-05-23

申请号：US15539475

申请日：2016-12-05

Applicant: Colorado State University Research Foundation

Inventor： Travis S. Bailey ,  Kristine Fischenich ,  Jackson T. Lewis ,  Tammy Haut Donahue ,  Chen Guo

IPC: A61L27/52 ,  C08J3/075 ,  A61L27/26 ,  C08L53/00 ,  C08G81/02

Abstract: Provided herein is a soft tissue mimetic formed from a block copolymer hydrogel and methods of making such. The hydrogel comprises a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO-SOS by weight. The soft tissue mimetic has a fatigue resistance to at least 500,000 compression cycles.