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公开(公告)号：US20080063681A1
公开(公告)日：2008-03-13
申请号：US11519168
申请日：2006-09-11
Applicant: Bruce Simon , Joshua Simon
Inventor： Bruce Simon , Joshua Simon
CPC classification number: A61K6/0625 , A61F2/28 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61L27/025 , A61L27/54 , A61L2300/252 , A61L2300/406 , A61L2300/414 , A61L2300/604 , A61L2430/02
Abstract: A biodegradable bone replacement material for the treatment of bone defects and delivery of antibiotic compounds, particularly for treating bone infections, comprising calcium sulfate hemihydrate, calcium sulfate dihydrate, an antibiotic mixture comprising a tetracycline compound and an ansamycin compound. Preferably, the ratio of calcium sulfate hemihydrate to calcium sulfate dihydrate is from 1:1 to about 3:1. Methods for treating, repairing or augmenting an osseous defect using the bone replacement material are also provided.
Abstract translation: 一种可生物降解的骨替代材料，用于治疗骨缺损和递送抗生素化合物，特别是用于治疗骨感染，包括硫酸钙半水合物，硫酸钙二水合物，包含四环素化合物和安莎霉素化合物的抗生素混合物。 优选地，半水合硫酸钙与硫酸钙二水合物的比例为1:1至约3:1。 还提供了使用骨置换材料治疗，修复或增加骨缺损的方法。
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Patent Agency Ranking
公开(公告)号：US20080255041A1
公开(公告)日：2008-10-16
申请号：US11786154
申请日：2007-04-11
Applicant: Bruce Simon , Joshua Simon
Inventor： Bruce Simon , Joshua Simon
CPC classification number: B82Y5/00 , A61K38/1825 , A61K47/62 , A61K47/66
Abstract: Compositions and methods for treating an annulus fibrosis defect comprising an angiogenic factor and a carrier. Methods include administering the composition to the annulus fibrosis defect, where the administering can include injecting the composition. The present compositions can stimulate angiogenesis and revascularization thereby facilitating repair of the defect.
Abstract translation: 用于治疗包含血管生成因子和载体的环状纤维化缺陷的组合物和方法。 方法包括给予环状纤维化缺陷，其中给药可以包括注射组合物。 本发明的组合物可以刺激血管生成和血运重建，从而有助于修复缺损。
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公开(公告)号：US20150157103A1
公开(公告)日：2015-06-11
申请号：US14101136
申请日：2013-12-09
Applicant: Joshua Simon
Inventor： Joshua Simon
IPC: A45C11/00
CPC classification number: G06F1/1628 , A45C2011/003 , G06F1/1632
Abstract: An electronic device case includes an upper shell having an upper edge, a lower edge, a left edge, a right edge and a center region surrounded by the edges. A lower shell is pivotally coupled with the upper shell and formed to include a frame configured to surround and hold an electronic device input peripheral. A number of grips are adjustably engaged with a guide track of the upper shell to support and stabilize any of a variety of electronic devices of different sizes. A number of actuation rods having first ends comprising knobs and second ends coupled with the grips cause translation of the grips along the guide track when slid along the upper, left and right edges of the upper shell.
Abstract translation: 电子设备壳体包括具有上边缘，下边缘，左边缘，右边缘和由边缘包围的中心区域的上壳体。 下壳体与上壳体枢转地联接并且形成为包括构造成围绕和保持电子设备输入外围设备的框架。 多个把手可调节地与上壳的导轨接合，以支撑和稳定各种不同尺寸的电子装置中的任何一个。 许多具有第一端的致动杆包括旋钮和与夹具连接的第二端，当沿着上壳体的上，左和右边缘滑动时，导向夹具沿导轨平移。
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公开(公告)号：US20080033572A1
公开(公告)日：2008-02-07
申请号：US11498341
申请日：2006-08-03
Applicant: Paul D'Antonio , Joshua Simon , Benjamin T. Cripps
Inventor： Paul D'Antonio , Joshua Simon , Benjamin T. Cripps
IPC: A61F2/28
CPC classification number: A61K35/32 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30224 , A61F2002/30677 , A61F2002/4649 , A61F2230/0069 , A61F2310/00293 , A61F2310/00365 , A61K38/39 , A61L27/3608 , A61L27/365 , A61L27/3804 , A61L27/46 , A61L2430/02 , A61K2300/00
Abstract: Bone graft compositions comprising demineralized bone matrix, calcium phosphate, collagen and bioinductive cellular solution. Methods to repair and heal defective and missing bone using the bone graft compositions are also described.
Abstract translation: 骨移植组合物包含软化骨基质，磷酸钙，胶原和生物传导细胞溶液。 还描述了使用骨移植组合物修复和愈合缺陷和缺失骨的方法。
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公开(公告)号：US20100098673A1
公开(公告)日：2010-04-22
申请号：US12643604
申请日：2009-12-21
Applicant: Paul D'ANTONIO , Joshua Simon , Benjamin T. Cripps
Inventor： Paul D'ANTONIO , Joshua Simon , Benjamin T. Cripps
CPC classification number: A61K35/32 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30224 , A61F2002/30677 , A61F2002/4649 , A61F2230/0069 , A61F2310/00293 , A61F2310/00365 , A61K38/39 , A61L27/3608 , A61L27/365 , A61L27/3804 , A61L27/46 , A61L2430/02 , A61K2300/00
Abstract: Bone graft compositions comprising demineralized bone matrix, calcium phosphate, collagen and bioinductive cellular solution. Methods to repair and heal defective and missing bone using the bone graft compositions are also described.
Abstract translation: 骨移植组合物包含软化骨基质，磷酸钙，胶原和生物传导细胞溶液。 还描述了使用骨移植组合物修复和愈合缺陷和缺失骨的方法。
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公开(公告)号：US20090226668A1
公开(公告)日：2009-09-10
申请号：US12045463
申请日：2008-03-10
Applicant: Joshua Simon
Inventor： Joshua Simon
CPC classification number: A61L27/10 , A61F2/0077 , A61F2/28 , A61F2/30767 , A61F2/3094 , A61F2002/30032 , A61F2002/30064 , A61F2002/3082 , A61F2002/30838 , A61F2002/3092 , A61F2002/30929 , A61F2002/3096 , A61F2240/001 , A61F2250/003 , A61F2310/00179 , A61F2310/00293 , A61F2310/00365 , A61F2310/00928 , A61F2310/00976 , A61F2310/00982 , A61F2310/00988 , A61L27/30 , A61L27/34 , A61L2400/18 , Y10T428/24372 , Y10T428/24479 , Y10T428/24926
Abstract: A ceramic scaffold comprising a ceramic substrate having a surface with a first microtexture on at least a portion of the surface and a first erodable coating having a smooth surface, said first coating covering at least a portion of the first microtexture. The microtexture may be formed of peaks, valleys, or a combination of peaks and valleys from about 1 micrometer to about 100 micrometers in each of height, length, and width. The peaks, valleys, or combination of peaks and valleys may be elongated and oriented in the same direction on the surface. The microtexture may also be asymmetrically arranged on the surface of the ceramic substrate.
Abstract translation: 一种陶瓷支架，其包括具有在所述表面的至少一部分上具有第一微纹理的表面的陶瓷基底和具有平滑表面的第一可侵蚀涂层，所述第一涂层覆盖所述第一微纹理的至少一部分。 微纹理可以由高度，长度和宽度各自的大约1微米到大约100微米的峰，谷或峰和谷的组合形成。 峰，谷或峰和谷的组合可以在表面上沿相同方向伸长并定向。 微纹理也可以不对称地布置在陶瓷基片的表面上。
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