公开(公告)号：US08483832B2

公开(公告)日：2013-07-09

申请号：US12469397

申请日：2009-05-20

Applicant: Bruce Simon

Inventor： Bruce Simon

IPC: A61N1/36

CPC classification number: A61N1/0456 ,  A61N1/36007 ,  A61N1/3601 ,  A61N1/36017 ,  A61N1/36114 ,  A61N1/36117

Abstract: Systems and devices for selectively applying electrical energy to a target region beneath a skin surface of a patient involve applying an electrical impulse to one or more electrodes on a skin surface of the patient to modulate one or more nerves at the target region, where the impulse is substantially blocked at nerves located between the target region and the skin surface such that only the nerves at the target region are modulated by the electrical impulse.

Abstract translation: 用于选择性地将电能施加到患者皮肤表面下的目标区域的系统和装置涉及将电脉冲施加到患者皮肤表面上的一个或多个电极，以调制目标区域上的一个或多个神经，其中脉冲 在位于目标区域和皮肤表面之间的神经处基本阻塞，使得仅目标区域的神经被电脉冲调制。

公开(公告)号：US08401650B2

公开(公告)日：2013-03-19

申请号：US12394972

申请日：2009-02-27

Applicant: Bruce Simon ,  Steven Mendez ,  Hecheng Hu ,  Richard P. Dickerson ,  James R. Pastena ,  Puyun Guo

Inventor： Bruce Simon ,  Steven Mendez ,  Hecheng Hu ,  Richard P. Dickerson ,  James R. Pastena ,  Puyun Guo

IPC: A61N1/00

CPC classification number: A61N1/05 ,  A61M2025/105 ,  A61N1/0517 ,  A61N1/0519 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/3605 ,  A61N1/375 ,  A61N1/40

Abstract: The present invention provides systems, apparatus and methods for selectively applying electrical energy to body tissue. A device is provided having an enclosure within an outer wall formed from an electrically-permeable material to allow for electrical energy to pass from the interior of the enclosure through the outer wall. The device further includes an electrode positioned within the interior of the enclosure and a fluid passage coupled to the enclosure for delivery of an electrically conductive fluid into the interior of the enclosure such that the electrically conductive fluid couples the electrode with the electrically-permeable section of the outer wall. The conductive fluid allows for the passage of electrical energy from the electrode through the fluid and the outer wall of the enclosure for treatment of tissue on or in a patient. In this manner, the electrode does not directly contact the tissue of the patient, which reduces the potential for collateral tissue damage or necrosis and/or excessive electric fields in the tissue.

Abstract translation: 本发明提供了用于选择性地向身体组织施加电能的系统，装置和方法。 提供了一种装置，其具有由电渗透材料形成的外壁内的外壳，以允许电能从外壳的内部通过外壁。 该装置还包括位于外壳内部的电极和耦合到外壳的流体通道，用于将导电流体输送到外壳的内部，使得导电流体将电极与电渗透部分 外墙。 导电流体允许来自电极的电能通过外壳的流体和外壁，用于治疗患者身上或患者中的组织。 以这种方式，电极不直接接触患者的组织，这降低了组织中侧支组织损伤或坏死和/或过度电场的可能性。

公开(公告)号：US20110276107A1

公开(公告)日：2011-11-10

申请号：US13183721

申请日：2011-07-15

Applicant: Bruce Simon ,  Joseph P. Errico ,  John T. Raffle

Inventor： Bruce Simon ,  Joseph P. Errico ,  John T. Raffle

IPC: A61N1/40

CPC classification number: A61N2/006 ,  A61N1/36021 ,  A61N1/40 ,  A61N2/008 ,  A61N2/02

Abstract: Transcutaneous electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including nasal or paranasal sinus symptoms that resemble an immune-mediated response (“sinus” headaches). The devices and methods may also be used to treat rhinitis, sinusitis, or rhinosinusitis, irrespective of whether those disorders are co-morbid with a headache. They may also be used to treat other disorders that may be co-morbid with migraine or cluster headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.

Abstract translation: 公开了经皮电神经刺激装置和磁刺激装置，以及使用通过这种装置非侵入地输送的能量来治疗医学病症的方法。 这些疾病包括偏头痛和其他原发性头痛，例如丛集性头痛，包括类似于免疫介导的反应（“窦”头痛）的鼻或鼻旁窦症状。 装置和方法也可用于治疗鼻炎，鼻窦炎或鼻鼻窦炎，而不管这些疾病是否与头痛并发症。 它们也可用于治疗可能与偏头痛或丛集性头痛如焦虑症共病的其他疾病。 在所公开的方法的优选实施例中，患者的迷走神经中的一个或两个被非侵入性地刺激。 在其它实施方案中，刺激部分交感神经系统和/或肾上腺。

公开(公告)号：US20110125203A1

公开(公告)日：2011-05-26

申请号：US12964050

申请日：2010-12-09

Applicant: Bruce Simon ,  Joseph P. Errico ,  John T. Raffle

Inventor： Bruce Simon ,  Joseph P. Errico ,  John T. Raffle

IPC: A61N1/36

CPC classification number: A61N2/02 ,  A61N1/36 ,  A61N1/36114 ,  A61N1/40 ,  A61N2/006

Abstract: Devices and systems are disclosed for the non-invasive treatment of medical conditions through delivery of energy to target tissue, comprising a source of electrical power, a magnetically permeable toroidal core, and a coil that is wound around the core. The coil and core are embedded in a continuous electrically conducting medium, which is adapted to have a shape that conforms to the contour of an arbitrarily oriented target body surface of a patient. The conducting medium is applied to that surface by any of several disclosed methods, and the source of power supplies a pulse of electric charge to the coil, such that the coil induces an electric current and/or an electric field within the patient, thereby stimulating tissue and/or one or more nerve fibers within the patient. The invention shapes an elongated electric field of effect that can be oriented parallel to a long nerve. In one embodiment, the device comprises two toroidal cores that lie adjacent to one another.

Abstract translation: 公开了用于通过向目标组织递送能量而非医疗状况的非侵入式治疗的装置和系统，包括电源，磁导环形芯和卷绕在芯上的线圈。 线圈和芯体嵌入连续的导电介质中，其适于具有符合患者任意取向的目标体表面轮廓的形状。 导电介质通过几种公开的方法中的任何一种施加到该表面，并且电源将电荷脉冲提供给线圈，使得线圈在患者体内引起电流和/或电场，由此刺激 组织和/或患者体内的一种或多种神经纤维。 本发明形成了可以平行于长神经定向的细长的效应电场。 在一个实施例中，该装置包括彼此相邻的两个环形芯。

公开(公告)号：US20090281593A9

公开(公告)日：2009-11-12

申请号：US12408131

申请日：2009-03-20

Applicant: Joseph P. Errico ,  James R. Pastena ,  Steven Mendez ,  Hecheng Hu ,  Arthur Ross ,  Bruce Simon

Inventor： Joseph P. Errico ,  James R. Pastena ,  Steven Mendez ,  Hecheng Hu ,  Arthur Ross ,  Bruce Simon

IPC: A61N1/36

CPC classification number: A61N1/3611 ,  A61N1/0517 ,  A61N1/0519 ,  A61N1/0526 ,  A61N1/0551 ,  A61N1/3601 ,  A61N1/36017 ,  A61N1/36053 ,  A61N1/36146

Abstract: Devices, systems and methods for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease wherein the treatment includes stimulating selected nerve fibers responsible for smooth muscle dilation at a selected region within a patient's neck, thereby reducing the magnitude of constriction of bronchial smooth muscle.

Abstract translation: 用于治疗与哮喘，过敏反应或慢性阻塞性肺疾病相关的支气管收缩的装置，系统和方法，其中所述治疗包括在患者颈部内的选定区域刺激负责平滑肌扩张的选定神经纤维，从而减少支气管平滑 肌肉。

公开(公告)号：US20080255041A1

公开(公告)日：2008-10-16

申请号：US11786154

申请日：2007-04-11

Applicant: Bruce Simon ,  Joshua Simon

Inventor： Bruce Simon ,  Joshua Simon

IPC: A61K38/16 ,  A61P43/00 ,  A61K38/10 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/03

CPC classification number: B82Y5/00 ,  A61K38/1825 ,  A61K47/62 ,  A61K47/66

Abstract: Compositions and methods for treating an annulus fibrosis defect comprising an angiogenic factor and a carrier. Methods include administering the composition to the annulus fibrosis defect, where the administering can include injecting the composition. The present compositions can stimulate angiogenesis and revascularization thereby facilitating repair of the defect.

Abstract translation: 用于治疗包含血管生成因子和载体的环状纤维化缺陷的组合物和方法。 方法包括给予环状纤维化缺陷，其中给药可以包括注射组合物。 本发明的组合物可以刺激血管生成和血运重建，从而有助于修复缺损。

公开(公告)号：US09174066B2

公开(公告)日：2015-11-03

申请号：US13222087

申请日：2011-08-31

Applicant: Bruce Simon ,  Joseph Errico ,  John T. Raffle

Inventor： Bruce Simon ,  Joseph Errico ,  John T. Raffle

IPC: A61N1/04 ,  A61N1/36 ,  A61N2/00 ,  A61N1/40 ,  A61N2/02

CPC classification number: A61N1/36014 ,  A61N1/0456 ,  A61N1/40 ,  A61N2/006 ,  A61N2/008 ,  A61N2/02

Abstract: A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.

Abstract translation: 非侵入性电刺激装置形成可以平行于长神经（例如患者颈部的迷走神经）定向的细长的电场，在患者体内产生期望的生理反应。 刺激器包括电源，至少一个电极和连续导电介质，其中电极接触。 刺激装置被配置为产生峰值脉冲电压，该峰值脉冲电压足以在目标神经附近产生生理有效的电场，但是不能基本上刺激位于目标神经附近和患者皮肤之间的其它神经和肌肉 。 电流以优选五个正弦脉冲的脉冲串通过电极，其中脉冲串内的每个脉冲具有优选200微秒的持续时间，并且优选地以每秒15-50个突发重复突发。

公开(公告)号：US08983629B2

公开(公告)日：2015-03-17

申请号：US13603810

申请日：2012-09-05

Applicant: Bruce Simon ,  Joseph P. Errico ,  John T. Raffle

Inventor： Bruce Simon ,  Joseph P. Errico ,  John T. Raffle

IPC: A61N1/18 ,  A61N1/36 ,  A61N1/40 ,  A61N2/00 ,  A61N2/02 ,  A61B5/08

CPC classification number: A61N1/3601 ,  A61B5/08 ,  A61B5/082 ,  A61N1/40 ,  A61N2/006 ,  A61N2/008 ,  A61N2/02

Abstract: Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis, chronic obstructive pulmonary disease (COPD), exercise-induced bronchospasm and post-operative bronchospasm. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that activate neural pathways to reduce the release of acetycholine from airway-related vagal preganglionic neurons within the brain of the patient. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to produce the bronchodilation.

Abstract translation: 公开了用于治疗与哮喘，过敏反应，慢性阻塞性肺病（COPD），运动性支气管痉挛和手术后支气管痉挛有关的支气管收缩的装置，系统和方法。 该治疗包括将能量非侵入性的脉冲传递到选择的神经纤维，所述神经纤维激活神经通路，以减少乙酰胆碱从患者脑内的气道相关的迷走神经节前神经元的释放。 包括磁能和/或电能的透射能量脉冲刺激所选择的神经纤维产生支气管扩张。

公开(公告)号：US08874205B2

公开(公告)日：2014-10-28

申请号：US13075746

申请日：2011-03-30

Applicant: Bruce Simon ,  Joseph P. Errico ,  John T. Raffle

Inventor： Bruce Simon ,  Joseph P. Errico ,  John T. Raffle

IPC: A61N1/40 ,  A61N1/36

CPC classification number: A61N1/40 ,  A61N1/36014 ,  A61N1/36017 ,  A61N1/36114

Abstract: A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.

Abstract translation: 非侵入性电刺激装置形成可以平行于长神经（例如患者颈部的迷走神经）定向的细长的电场，在患者体内产生期望的生理反应。 刺激器包括电源，至少一个电极和连续导电介质，其中电极接触。 刺激装置被配置为产生峰值脉冲电压，该峰值脉冲电压足以在目标神经附近产生生理有效的电场，但是不能基本上刺激位于目标神经附近和患者皮肤之间的其它神经和肌肉 。 电流以优选五个正弦脉冲的脉冲串通过电极，其中脉冲串内的每个脉冲具有优选200微秒的持续时间，并且优选地以每秒15-50个突发重复突发。

公开(公告)号：US08663146B2

公开(公告)日：2014-03-04

申请号：US13234675

申请日：2011-09-16

Applicant: Joel C. Higgins ,  Bruce Simon ,  Jennifer E. Woodell-May

Inventor： Joel C. Higgins ,  Bruce Simon ,  Jennifer E. Woodell-May

IPC: A61M1/00 ,  A61M35/00 ,  A61M37/00 ,  A61K41/00 ,  A61K35/14 ,  A61K35/16 ,  A61N2/02

CPC classification number: A61K35/19 ,  A61K35/16 ,  A61K35/28 ,  A61K35/35 ,  A61K38/18 ,  A61K38/19 ,  A61K45/06 ,  A61M37/00 ,  A61N1/205 ,  A61N1/326 ,  A61N2/02 ,  C12N13/00 ,  A61K2300/00

Abstract: Methods for promoting angiogenesis comprising administering platelet-rich plasma to a site and stimulating the site with an electromagnetic field. Platelets include platelet-rich plasma and compositions can further include stem cells such as adipose stromal cells and cells derived from bone marrow aspirate. Methods also comprise isolating platelets from a patient's blood, forming a composition including the platelets, delivering the composition to a site in need of treatment, and electrically stimulating the site.

Abstract translation: 促进血管发生的方法包括将血小板富集的血浆施用于部位并用电磁场刺激部位。 血小板包括富含血小板的血浆，组合物还可以包括干细胞如脂肪基质细胞和源自骨髓抽吸物的细胞。 方法还包括从患者血液中分离血小板，形成包括血小板的组合物，将组合物递送至需要治疗的部位，以及电刺激该部位。