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    Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient
    1.
    发明授权
    Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient 有权
    用于非侵入性电容电刺激的装置和方法及其用于患者颈部的迷走神经刺激

    公开(公告)号：US09174066B2

    公开(公告)日：2015-11-03

    申请号：US13222087

    申请日：2011-08-31

    申请人： Bruce Simon ,  Joseph Errico ,  John T. Raffle

    发明人： Bruce Simon ,  Joseph Errico ,  John T. Raffle

    IPC分类号： A61N1/04 ,  A61N1/36 ,  A61N2/00 ,  A61N1/40 ,  A61N2/02

    CPC分类号： A61N1/36014 ,  A61N1/0456 ,  A61N1/40 ,  A61N2/006 ,  A61N2/008 ,  A61N2/02

    摘要： A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.

    摘要翻译： 非侵入性电刺激装置形成可以平行于长神经（例如患者颈部的迷走神经）定向的细长的电场，在患者体内产生期望的生理反应。 刺激器包括电源，至少一个电极和连续导电介质，其中电极接触。 刺激装置被配置为产生峰值脉冲电压，该峰值脉冲电压足以在目标神经附近产生生理有效的电场，但是不能基本上刺激位于目标神经附近和患者皮肤之间的其它神经和肌肉 。 电流以优选五个正弦脉冲的脉冲串通过电极，其中脉冲串内的每个脉冲具有优选200微秒的持续时间，并且优选地以每秒15-50个突发重复突发。

    DEVICES AND METHODS FOR NON-INVASIVE CAPACITIVE ELECTRICAL STIMULATION AND THEIR USE FOR VAGUS NERVE STIMULATION ON THE NECK OF A PATIENT
    2.
    发明申请
    DEVICES AND METHODS FOR NON-INVASIVE CAPACITIVE ELECTRICAL STIMULATION AND THEIR USE FOR VAGUS NERVE STIMULATION ON THE NECK OF A PATIENT 有权
    非侵入性电刺激的装置和方法及其对患者NECK刺激的VAGUS神经刺激的使用

    公开(公告)号：US20120029601A1

    公开(公告)日：2012-02-02

    申请号：US13222140

    申请日：2011-08-31

    申请人： Bruce Simon ,  Joseph Errico ,  John T. Raffle

    发明人： Bruce Simon ,  Joseph Errico ,  John T. Raffle

    IPC分类号： A61N1/36

    CPC分类号： A61N2/006 ,  A61N1/375 ,  A61N1/40 ,  A61N2/008 ,  A61N2/02

    摘要： A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.

    摘要翻译： 非侵入性电刺激装置形成可以平行于长神经（例如患者颈部的迷走神经）定向的细长的电场，在患者体内产生期望的生理反应。 刺激器包括电源，至少一个电极和连续导电介质，其中电极接触。 刺激装置被配置为产生峰值脉冲电压，该峰值脉冲电压足以在目标神经附近产生生理有效的电场，但是不能基本上刺激位于目标神经附近和患者皮肤之间的其它神经和肌肉 。 电流以优选五个正弦脉冲的脉冲串通过电极，其中脉冲串内的每个脉冲具有优选200微秒的持续时间，并且优选地以每秒15-50个突发重复突发。

    Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient
    3.
    发明授权
    Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient 有权
    用于非侵入性电容电刺激的装置和方法及其用于患者颈部的迷走神经刺激

    公开(公告)号：US08914122B2

    公开(公告)日：2014-12-16

    申请号：US13222140

    申请日：2011-08-31

    申请人： Bruce Simon ,  Joseph Errico ,  John T Raffle

    发明人： Bruce Simon ,  Joseph Errico ,  John T Raffle

    IPC分类号： A61N1/18 ,  A61N1/34 ,  A61N2/00 ,  A61N1/40 ,  A61N1/375 ,  A61N2/02

    CPC分类号： A61N2/006 ,  A61N1/375 ,  A61N1/40 ,  A61N2/008 ,  A61N2/02

    摘要： A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.

    摘要翻译： 非侵入性电刺激装置形成可以平行于长神经（例如患者颈部的迷走神经）定向的细长的电场，在患者体内产生期望的生理反应。 刺激器包括电源，至少一个电极和连续导电介质，其中电极接触。 刺激装置被配置为产生峰值脉冲电压，该峰值脉冲电压足以在目标神经附近产生生理有效的电场，但是不能基本上刺激位于目标神经附近和患者皮肤之间的其它神经和肌肉 。 电流以优选五个正弦脉冲的脉冲串通过电极，其中脉冲串内的每个脉冲具有优选200微秒的持续时间，并且优选地以每秒15-50个突发重复突发。

    NON-INVASIVE ELECTRICAL AND MAGNETIC NERVE STIMULATORS USED TO TREAT OVERACTIVE BLADDER AND URINARY INCONTINENCE
    4.
    发明申请
    NON-INVASIVE ELECTRICAL AND MAGNETIC NERVE STIMULATORS USED TO TREAT OVERACTIVE BLADDER AND URINARY INCONTINENCE 有权
    非侵入式电磁神经刺激器用于治疗过敏性刮板和尿失禁

    公开(公告)号：US20120101326A1

    公开(公告)日：2012-04-26

    申请号：US13279437

    申请日：2011-10-24

    申请人： Bruce Simon ,  Joseph Errico ,  John T. Raffle

    发明人： Bruce Simon ,  Joseph Errico ,  John T. Raffle

    IPC分类号： A61N2/00 ,  A61N1/36

    CPC分类号： A61N1/36007 ,  A61N1/0456 ,  A61N1/36014 ,  A61N2/006

    摘要： Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of treating lower urinary tract disorders using energy that is delivered noninvasively by the devices. The disorders comprise overactive bladder, urge incontinence, stress, incontinence, urge frequency, non-obstructive urinary retention and interstitial cystitis/painful bladder syndrome. In preferred embodiments of the disclosed methods, a posterior tibial nerve of a patient is stimulated non-invasively. Methods are disclosed for selecting protocol parameters for a nerve stimulation session for treating each individual patient, wherein modules of the bladder of the patient are represented as coupled non-linear oscillators.

    摘要翻译： 公开了经皮电磁神经刺激装置，以及使用由装置非侵入性输送的能量治疗下尿路障碍的方法。 这些疾病包括膀胱过度活动，急迫性尿失禁，压力，失禁，呼吸频率，非梗阻性尿潴留和间质性膀胱炎/疼痛膀胱综合征。 在所公开的方法的优选实施例中，患者的后胫神经被非侵入性地刺激。 公开了用于选择用于治疗每个单独患者的神经刺激会话的协议参数的方法，其中患者膀胱的模块被表示为耦合的非线性振荡器。

    INTERVERTEBRAL SPACER DEVICE HAVING AN ENGAGEMENT HOLE FOR A TOOL WITH AN EXTENDABLE POST
    7.
    发明申请
    INTERVERTEBRAL SPACER DEVICE HAVING AN ENGAGEMENT HOLE FOR A TOOL WITH AN EXTENDABLE POST 有权
    具有可扩展性的工具的嵌入孔的横向间隔装置

    公开(公告)号：US20100036494A9

    公开(公告)日：2010-02-11

    申请号：US10663488

    申请日：2003-09-16

    申请人： Joseph Errico ,  Michael Dudasik ,  Rafail Zubok

    发明人： Joseph Errico ,  Michael Dudasik ,  Rafail Zubok

    IPC分类号： A61F2/44

    CPC分类号： A61F2/4684 ,  A61F2/4425 ,  A61F2/4611 ,  A61F2002/30785 ,  A61F2002/30841 ,  A61F2002/443 ,  A61F2002/4619 ,  A61F2002/4627 ,  A61F2002/4628 ,  A61F2002/4658 ,  Y10S606/914

    摘要： Instrumentation for implanting an artificial intervertebral disc includes static trials and a dynamic trial for determining the appropriate size of disc to be implanted, static trial holders for manipulating the static trials, inserter/impactors for inserting and removing the static trials and for inserting the artificial intervertebral discs, repositioners/extractors for repositioning and extracting the static trials or the artificial intervertebral discs, and a leveler for setting the proper position of the artificial intervertebral disc. Methods for using the same are also disclosed. Features for artificial intervertebral discs and intervertebral spacer devices useful for manipulation by the instrumentation are also disclosed.

    摘要翻译： 用于植入人造椎间盘的仪器包括静态试验和用于确定要植入的椎间盘的适当尺寸的动态试验，用于操纵静态试验的静态试验架，用于插入和移除静态试验的插入器/冲击器以及插入人造椎间盘 用于重新定位和提取静态试验或人造椎间盘的光盘，重新定位器/提取器，以及用于设定人造椎间盘的适当位置的矫直器。 还公开了使用该方法的方法。 还公开了可用于仪器操作的人造椎间盘和椎间间隔器的特征。

    Stabilized proteins
    9.
    发明申请
    Stabilized proteins 失效
    稳定蛋白

    公开(公告)号：US20070184518A1

    公开(公告)日：2007-08-09

    申请号：US11699588

    申请日：2007-01-29

    申请人： Christopher Marshall ,  Alexander Hoffman ,  Joseph Errico ,  Paul Marshall

    发明人： Christopher Marshall ,  Alexander Hoffman ,  Joseph Errico ,  Paul Marshall

    IPC分类号： C12P21/06 ,  C12N9/00 ,  C12N9/18 ,  C07K16/46 ,  C07K14/705 ,  C07K14/475

    CPC分类号： C07K16/00 ,  C07K2317/56 ,  C12N9/00 ,  C12N9/20 ,  C12N9/54 ,  C12N9/96

    摘要： Isolated polypeptides or polypeptide chains are modified by di-tyrosine cross-linking such that they retain at least one functional activity. In one embodiment, the isolated polypeptide or polypeptide chains comprise at least one di-tyrosine cross-link, wherein at least one tyrosine of the di-tyrosine cross-link originates from a point mutation to tyrosine, and wherein the di-tyrosine cross-linked protein retains at least one function displayed by the protein in the absence of di-tyrosine cross-linking. In another embodiment, the di-tyrosine cross-linked polypeptide or polypeptide chain has enhanced stability compared to the same polypeptide or polypeptide chain in the absence of di-tyrosine cross-linking. A method for stabilization of a polypeptide or polypeptide complex, by the introduction of intra-polypeptide and/or inter-polypeptide di-tyrosine bonds, which simultaneously maintains the structure and function of the polypeptide or polypeptide complex is also described.

    摘要翻译： 通过二酪氨酸交联修饰分离的多肽或多肽链，使得它们保留至少一种功能活性。 在一个实施方案中，分离的多肽或多肽链包含至少一个二酪氨酸交联，其中所述二酪氨酸交联的至少一个酪氨酸源于对酪氨酸的点突变，并且其中所述二酪氨酸交联 连接的蛋白质在不存在二酪氨酸交联的情况下保留蛋白质显示的至少一种功能。 在另一个实施方案中，与没有二酪氨酸交联的相同多肽或多肽链相比，二酪氨酸交联的多肽或多肽链具有增强的稳定性。 还描述了通过引入同时维持多肽或多肽复合物的结构和功能的多肽内和/或多肽内二酪氨酸键来稳定多肽或多肽复合物的方法。