-
公开(公告)号：US09932320B2
公开(公告)日：2018-04-03
申请号：US15112294
申请日：2015-01-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , John E. Macor , Joanne J. Bronson , Bireshwar Dasgupta , Carolyn Diane Dzierba , Susheel Jethanand Nara , Maheswaran Sivasamban Karatholuvhu
IPC: C07D401/14 , C07D401/04 , C07D215/12 , C07D215/18 , C07D413/04 , C07D471/04
CPC classification number: C07D401/04 , C07D215/12 , C07D215/18 , C07D401/14 , C07D413/04 , C07D471/04
Abstract: The present disclosure is generally directed to compounds of formula (I) which can inhibit AAKI (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAKI.
-
公开(公告)号：US11166959B2
公开(公告)日：2021-11-09
申请号：US16761449
申请日：2018-11-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Erika M. V. Araujo , Yan Chen , Bireshwar Dasgupta , Andrew P. Degnan , Matthew D. Hill , Godwin Kwame Kumi , Harold A. Mastalerz , Mark D. Wittman , Bradley C. Pearce , Guifen Zhang
IPC: A61K31/5377 , A61K31/506 , A61P35/00 , A61K45/06 , C07D405/12 , C07D405/14 , C07D413/14 , C07D453/02 , C07D491/048 , C07D498/10 , C07D519/00
Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is CH or N; Y is CR5 or N; and R1, R2, R3, R4, and R5 are defined herein. Also disclosed are methods of using such compounds to modulate or inhibit the enzymatic activity of hematopoietic progenitor kinase 1 (HPK1), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
-
公开(公告)号：US10954238B1
公开(公告)日：2021-03-23
申请号：US16843024
申请日：2020-04-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC: C07D403/04 , C07D487/04 , A61K31/196 , C07D471/04
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
-
公开(公告)号：US10035777B2
公开(公告)日：2018-07-31
申请号：US15500116
申请日：2015-07-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Carolyn Diane Dzierba , Joanne J. Bronson , John E. Macor , Bireshwar Dasgupta , Susheel Jethanand Nara , Vivekananda M. Vrudhula , Senliang Pan , Richard A. Hartz , Ramkumar Rajamani
IPC: C07D235/14 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07D401/14
CPC classification number: C07D235/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
-
公开(公告)号：US20170260145A1
公开(公告)日：2017-09-14
申请号：US15500116
申请日：2015-07-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Carolyn Diane Dzierba , Joanne J. Bronson , John E. Macor , Bireshwar Dasgupta , Susheel Jethanand Nara , Vivekananda M Vrudhula , Senliang Pan , Richard A. Hartz , Ramkumar Rajamani
IPC: C07D235/14 , C07D403/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07D401/14 , C07D401/04 , C07D413/04
CPC classification number: C07D235/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
-
Patent Agency Ranking
公开(公告)号：US11713316B2
公开(公告)日：2023-08-01
申请号：US17164009
申请日：2021-02-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC: C07D403/04 , C07D471/04 , C07D487/04 , A61K31/196
CPC classification number: C07D471/04
Abstract: Disclosed are compounds of Formula (I):
or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.-
公开(公告)号：US20230151007A1
公开(公告)日：2023-05-18
申请号：US17983097
申请日：2022-11-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender Velaparthi , Richard E. Olson , Chetan Padmakar Darne , Bireshwar Dasgupta , Jayakumar Sankara Warrier , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Denise Christine Grunenfelder
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Disclosed are compounds of Formula (I):
or a salt thereof, wherein: R1, R2, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKξ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.-
公开(公告)号：US20220324859A1
公开(公告)日：2022-10-13
申请号：US17164009
申请日：2021-02-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC: C07D471/04
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
-
公开(公告)号：US20210061802A1
公开(公告)日：2021-03-04
申请号：US17004058
申请日：2020-08-27
Applicant: Bristol-Myers Squibb Company
Inventor： Upender Velaparthi , Richard E. Olson , Chetan Padmakar Darne , Bireshwar Dasgupta , Jayakumar Sankara Warrier , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Denise Christine Grunenfelder
IPC: C07D471/04
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
-
![Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors](/abs-image/US/2017/03/21/US09598423B2/abs.jpg.150x150.jpg)
10.发明授权公开(公告)号：US09598423B2
公开(公告)日：2017-03-21
申请号：US15034217
申请日：2014-11-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender Velaparthi , Chetan Padmakar Darne , Peiying Liu , Mark D. Wittman , Bradley C. Pearce , Erika M. V. Araujo , Bireshwar Dasgupta , Jalathi Surendran Nair , Sakthi Kumaran Janakiraman , Chandrasekhar Reddy Rachamreddy , Mallikarjuna Rao Mettu , Arul Mozhi Selvan Subbiah Karuppiah , Bandreddy Subba Reddy , Pulicharla Nagalakshmi , Rajesh Onkardas Bora , Shilpa Holehatti Maheshwarappa , Selvakumar Kumaravel , Dibakar Mullick , Ramesh Sistla
IPC: A61K31/498 , C07D487/04 , C07D491/147 , C07D487/10 , C07D491/20 , C07D487/20 , C07D519/00
CPC classification number: C07D487/04 , C07D487/10 , C07D487/20 , C07D491/147 , C07D491/20 , C07D519/00
Abstract: The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.
-
-
-
-
-
-
-
-
-
Search Results
21
records
(took 0.028 seconds)
