Invention Publication
- Patent Title: SUBSTITUTED PYRIDOPYRIMIDINONYL COMPOUNDS USEFUL AS T CELL ACTIVATORS
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Application No.: US17983097Application Date: 2022-11-08
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Publication No.: US20230151007A1Publication Date: 2023-05-18
- Inventor: Upender Velaparthi , Richard E. Olson , Chetan Padmakar Darne , Bireshwar Dasgupta , Jayakumar Sankara Warrier , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Denise Christine Grunenfelder
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Main IPC: C07D471/04
- IPC: C07D471/04
Abstract:
Disclosed are compounds of Formula (I):
or a salt thereof, wherein: R1, R2, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKξ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
or a salt thereof, wherein: R1, R2, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKξ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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