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公开(公告)号：US10035777B2
公开(公告)日：2018-07-31
申请号：US15500116
申请日：2015-07-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Carolyn Diane Dzierba , Joanne J. Bronson , John E. Macor , Bireshwar Dasgupta , Susheel Jethanand Nara , Vivekananda M. Vrudhula , Senliang Pan , Richard A. Hartz , Ramkumar Rajamani
IPC: C07D235/14 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07D401/14
CPC classification number: C07D235/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
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公开(公告)号：US20170260145A1
公开(公告)日：2017-09-14
申请号：US15500116
申请日：2015-07-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Carolyn Diane Dzierba , Joanne J. Bronson , John E. Macor , Bireshwar Dasgupta , Susheel Jethanand Nara , Vivekananda M Vrudhula , Senliang Pan , Richard A. Hartz , Ramkumar Rajamani
IPC: C07D235/14 , C07D403/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07D401/14 , C07D401/04 , C07D413/04
CPC classification number: C07D235/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
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公开(公告)号：US20190315714A1
公开(公告)日：2019-10-17
申请号：US16463467
申请日：2017-11-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , Guanglin Luo , Ling Chen , Prasanna Sivaprakasam , Gene M. Dubowchik , Swannee E. Jacutin-Porte , John E. Macor
IPC: C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D417/14 , A61P25/28
Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds to treat disorders associated with GSK-3.
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公开(公告)号：US20160332985A1
公开(公告)日：2016-11-17
申请号：US15112294
申请日：2015-01-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , John E. Macor , Joanne J. Bronson , Bireshwar Dasgupta , Carolyn Diane Dzierba , Susheel Jethanand Nara , Maheswaran Sivasamban Karatholuvhu
IPC: C07D401/04 , C07D401/14 , C07D215/12 , C07D413/04 , C07D471/04
CPC classification number: C07D401/04 , C07D215/12 , C07D215/18 , C07D401/14 , C07D413/04 , C07D471/04
Abstract: The present disclosure is generally directed to compounds of formula (I) which can inhibit AAKI (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAKI.
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公开(公告)号：US09249180B2
公开(公告)日：2016-02-02
申请号：US14186533
申请日：2014-02-21
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jacob Swidorski , Yan Chen , Sing-Yuen Sit , Nicholas A. Meanwell , Alicia Regueiro-Ren , Jie Chen , Zheng Liu , Richard A. Hartz , Li Xu
IPC: A61K31/56 , A61K31/58 , C07J53/00 , C07J63/00 , A61K31/568
CPC classification number: C07J53/002 , A61K31/568 , A61K31/58 , C07J63/008
Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, alkyl and alkenyl C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV:a compound of Formula I a compound of Formula II a compound of Formula III and a compound of Formula IV The compounds are useful for the treatment of HIV and AIDS.
Abstract translation: 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的烷基和烯基C-3修饰的桦木酸衍生物作为HIV成熟抑制剂提供，如式I，II，III和IV化合物所示：式I化合物式IIa化合物 式III化合物和式IV化合物该化合物可用于治疗HIV和AIDS。
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Patent Agency Ranking
公开(公告)号：US20210323991A1
公开(公告)日：2021-10-21
申请号：US17251964
申请日：2019-06-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Li Xu , David S. Yoon , Alicia Regueiro-Ren , Prasada Rao Jalagam , Manoranjan Panda , Satheesh Kesavan Nair
Abstract: The present disclosure relates to compounds of Formula (1), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods making and using such compounds and compositions.
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公开(公告)号：US11970511B2
公开(公告)日：2024-04-30
申请号：US17251964
申请日：2019-06-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Li Xu , David S. Yoon , Alicia Regueiro-Ren , Prasada Rao Jalagam , Manoranjan Panda , Satheesh Kesavan Nair
Abstract: The present disclosure relates to compounds of Formula (1), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods making and using such compounds and compositions.
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公开(公告)号：US10774086B2
公开(公告)日：2020-09-15
申请号：US16463451
申请日：2017-11-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , Prasanna Sivaprakasam , Gene M. Dubowchik , John E. Macor
IPC: A61K31/5025 , C07D487/04
Abstract: The disclosure generally relates to compounds of formula (I), including their salts, as well as compositions and methods of using the compounds to treat disorders associated with GSK-3.
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公开(公告)号：US10752609B2
公开(公告)日：2020-08-25
申请号：US16463467
申请日：2017-11-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , Guanglin Luo , Ling Chen , Prasanna Sivaprakasam , Gene M. Dubowchik , Swanee E. Jacutin-Porte , John E. Macor
IPC: C07D401/12 , A61P25/28 , C07D401/14 , C07D403/12 , C07D405/14 , C07D417/14
Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds to treat disorders associated with GSK-3.
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公开(公告)号：US20190276463A1
公开(公告)日：2019-09-12
申请号：US16463451
申请日：2017-11-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , Prasanna Sivaprakasam , Gene M. Dubowchik , John E. Macor
IPC: C07D487/04
Abstract: The disclosure generally relates to compounds of formula (I), including their salts, as well as compositions and methods of using the compounds to treat disorders associated with GSK-3.
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