公开(公告)号：US12110290B2

公开(公告)日：2024-10-08

申请号：US18347703

申请日：2023-07-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Guanglin Luo ,  Jie Chen ,  Carolyn Diane Dzierba ,  David B. Frennesson ,  Junqing Guo ,  Amy C. Hart ,  Xirui Hu ,  Michael E. Mertzman ,  Matthew Reiser Patton ,  Jianliang Shi ,  Steven H. Spergel ,  Brian Lee Venables ,  Yong-Jin Wu ,  Zili Xiao ,  Michael G. Yang

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof,




are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

公开(公告)号：US20240109888A1

公开(公告)日：2024-04-04

申请号：US18347703

申请日：2023-07-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Guanglin Luo ,  Jie Chen ,  Carolyn Diane Dzierba ,  David B. Frennesson ,  Junqing Guo ,  Amy C. Hart ,  Xirui Hu ,  Michael E. Mertzman ,  Matthew Reiser Patton ,  Jianliang Shi ,  Steven H. Spergel ,  Brian Lee Venables ,  Yong-Jin Wu ,  Zili Xiao ,  Michael G. Yang

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof,




are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

公开(公告)号：US20220380335A1

公开(公告)日：2022-12-01

申请号：US17274220

申请日：2019-09-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Junqing Guo ,  Jie Chen ,  Carolyn Diane Dzierba ,  Amy C. Hart ,  Guanglin Luo ,  John E. Macor ,  Willian J. Pitts ,  Sing-Yuen Sit

IPC: C07D401/04 ,  C07D401/14 ,  C07D405/14

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, (I) are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

公开(公告)号：US10913738B2

公开(公告)日：2021-02-09

申请号：US16484604

申请日：2018-02-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Junqing Guo ,  Amy C. Hart ,  John E. Macor ,  Michael E. Mertzman ,  William J. Pitts ,  Steven H. Spergel ,  Scott Hunter Watterson ,  Murugaiah Andappan Murugaiah Subbaiah ,  Jie Chen ,  Carolyn Diane Dzierba ,  Guanglin Luo ,  Jianliang Shi ,  Sing-Yuen Sit

IPC: C07D471/04 ,  A61P29/00 ,  A61P19/02 ,  A61P17/06 ,  A61P1/00

Abstract: Compounds having formula (I) (IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX).

公开(公告)号：US20200317671A1

公开(公告)日：2020-10-08

申请号：US16913064

申请日：2020-06-26

Applicant: Bristol-Myers Squibb Company

Inventor： Guanglin Luo ,  Carolyn Diane Dzierba ,  John E. Macor

IPC: C07D471/04 ,  A61K31/4427 ,  A61P25/28 ,  C07D401/14 ,  C07D213/74 ,  C07D309/18 ,  C07D401/04 ,  C07D237/08 ,  A61K31/50 ,  C07C233/25 ,  C07D213/30 ,  C07D213/34 ,  C07D213/57 ,  C07D213/61 ,  C07D213/64 ,  C07D213/73 ,  C07D213/75 ,  C07D213/80 ,  C07D215/14 ,  C07D239/26 ,  C07D309/22 ,  C07D413/10

Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

公开(公告)号：US20190367508A1

公开(公告)日：2019-12-05

申请号：US16443929

申请日：2019-06-18

Applicant: Bristol-Myers Squibb Company

Inventor： Guanglin Luo ,  Carolyn Diane Dzierba ,  John E. Macor

IPC: C07D471/04 ,  A61K31/4427 ,  A61P25/28 ,  C07D401/14 ,  C07D213/74 ,  C07D309/18 ,  C07D401/04 ,  C07D237/08 ,  A61K31/50 ,  C07C233/25 ,  C07D213/30 ,  C07D213/34 ,  C07D213/57 ,  C07D213/61 ,  C07D213/64 ,  C07D213/73 ,  C07D213/75 ,  C07D213/80 ,  C07D215/14 ,  C07D239/26 ,  C07D309/22 ,  C07D413/10

Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

公开(公告)号：US10246469B2

公开(公告)日：2019-04-02

申请号：US15763281

申请日：2016-09-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Joanne J. Bronson ,  Ling Chen ,  Jonathan L. Ditta ,  Carolyn Diane Dzierba ,  Prasada Rao Jalagam ,  Guanglin Luo ,  John E. Macor ,  Tarun Kumar Maishal ,  Susheel Jethanand Nara ,  Ramkumar Rajamani ,  Ramesh Kumar Sistla ,  Soodamani Thangavel

IPC: C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D237/08 ,  C07D239/26 ,  C07D213/34 ,  A61K31/50 ,  A61K31/51 ,  A61K31/505 ,  A61K31/506 ,  A61K31/44 ,  A61K31/4427 ,  A61P25/28 ,  C07D513/04 ,  A61P25/18 ,  A61P25/16 ,  C07D213/74

Abstract: The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.

公开(公告)号：US20210277001A1

公开(公告)日：2021-09-09

申请号：US17192985

申请日：2021-03-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Guanglin Luo ,  Carolyn Diane Dzierba ,  John E. Macor

IPC: C07D471/04 ,  A61K31/4427 ,  A61P25/28 ,  C07D401/14 ,  C07D213/74 ,  C07D309/18 ,  C07D401/04 ,  C07D237/08 ,  A61K31/50 ,  C07C233/25 ,  C07D213/30 ,  C07D213/34 ,  C07D213/57 ,  C07D213/61 ,  C07D213/64 ,  C07D213/73 ,  C07D213/75 ,  C07D213/80 ,  C07D215/14 ,  C07D239/26 ,  C07D309/22 ,  C07D413/10

Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

公开(公告)号：US10981910B2

公开(公告)日：2021-04-20

申请号：US16913064

申请日：2020-06-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Guanglin Luo ,  Carolyn Diane Dzierba ,  John E. Macor

IPC: C07D401/04 ,  A61K31/4427 ,  A61P25/28 ,  A61P29/00 ,  C07D471/04 ,  C07D401/14 ,  C07D213/74 ,  C07D309/18 ,  C07D237/08 ,  A61K31/50 ,  C07C233/25 ,  C07D213/30 ,  C07D213/34 ,  C07D213/57 ,  C07D213/61 ,  C07D213/64 ,  C07D213/73 ,  C07D213/75 ,  C07D213/80 ,  C07D215/14 ,  C07D239/26 ,  C07D309/22 ,  C07D413/10

Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

公开(公告)号：US20200277296A1

公开(公告)日：2020-09-03

申请号：US16758892

申请日：2018-10-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Michael E. Mertzman ,  Carolyn Diane Dzierba ,  Jason M. Guernon ,  Amy C. Hart ,  Guanglin Luo ,  John E. Macor ,  William J. Pitts ,  Jianliang Shi ,  Steven H. Spergel

IPC: C07D487/04

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, (I) are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.